Regulation of chick neural crest cell migration by the Snail2 target alpha-N-catenin

Taneyhill, Lisa A.; Jhingory, Sharon; Wu, Chyong-Yi

doi:10.1016/j.ydbio.2009.05.157

Cited by 1 publication

(1 citation statement)

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“…EMT is characterized by loss of intercellular contacts and increasing components of the contractile cytoskeleton [26]. Numerous studies have demonstrated that EMT plays significant role in the process of invasion and metastasis of tumor development [27]. In our study, we found that β-catenin, E-cadherin, and N-cadherin were significantly reduced compared with NC groups, whereas vimentin was slightly reduced, suggesting that FAM3D-AS1 can reverse the EMT process.…”

Section: Discussionsupporting

confidence: 52%

Long noncoding RNA FAM3D-AS1 inhibits development of colorectal cancer through NF-κB signaling pathway

Meng

Feng

2019

Bioscience Reports

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Although numerous differential long noncoding RNAs (IncRNAs) have been identified, the relationship between lncRNA and colorectal cancer (CRC) still remains largely unclear. In the present study, we investigated the function and provided a possible mechanism of lncRNA FAM3D-AS1 in CRC. CCK8, transwell, and trypan blue staining were used to evaluate the proliferation, invasion, and cell death rates. Real-time PCR was used to elucidate the expression level of FAM3D-AS1. We found that lncRNA FAM3D-AS1 located in cytoplasm. Overexpression of FAM3D-AS1 significantly inhibited the cell proliferation, cell survival rates, and invaded cells. We also provided evidence that FAM3D-AS1 reversed the EMT process. Moreover, we proved that FAM3D-AS1 inhibits CRC development through NF-κB signaling pathway. Taken together, we performed functional analysis of FAM3D-AS1 and provided a possible mechanism in the development of CRC. Our study provided new targets for clinical treatment.

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Section: Discussionsupporting

confidence: 52%