Regulation of cell migration and inflammation by ceramide 1-phosphate

Presa, Natalia; Gómez-Larrauri, Ana; Rivera, Io-Guané; Ordoñez, Marta; Trueba, Miguel; Gómez-Muñoz, Antonio

doi:10.1016/j.bbalip.2016.02.007

Cited by 56 publications

(40 citation statements)

References 128 publications

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“…C1P, generated by ceramide kinase (CerK), is another important SL mediator derived from Cer metabolism. This molecule is involved in different inflammation processes, by acting as either pro‐ or anti‐inflammatory agent depending on the cell types . CerK knockout mice display severe neutropenia, which seems to be due to entrapment of neutrophils in bone marrow .…”

Section: Ceramide and Ceramide 1‐phosphatementioning

confidence: 99%

“…This molecule is involved in different inflammation processes, by acting as either pro-or anti-inflammatory agent depending on the cell types. 47 CerK knockout mice display severe neutropenia, which seems to be due to entrapment of neutrophils in bone marrow. 48 Conversely, C1P administration decreases the pro-inflammatory state of neutrophils in patients with chronic obstructive lung disease.…”

Section: Ceramide and Ceramide 1-phosphatementioning

confidence: 99%

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Sphingolipids role in the regulation of inflammatory response: From leukocyte biology to bacterial infection

Chiricozzi

Loberto

Schiumarini

et al. 2018

Journal of Leukocyte Biology

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Sphingolipids (SLs) are amphiphilic molecules mainly associated with the external leaflet of eukaryotic plasma membrane, and are structural membrane components with key signaling properties. Since the beginning of the last century, a large number of papers described the involvement of these molecules in several aspects of cell physiology and pathology. Several lines of evidence support the critical role of SLs in inflammatory diseases, by acting as anti- or pro-inflammatory mediators. They are involved in control of leukocyte activation and migration, and are recognized as essential players in host response to pathogenic infection. We propose here a critical overview of current knowledge on involvement of different classes of SLs in inflammation, focusing on the role of simple and complex SLs in pathogen-mediated inflammatory response.

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Section: Ceramide and Ceramide 1‐phosphatementioning

confidence: 99%

Section: Ceramide and Ceramide 1-phosphatementioning

confidence: 99%

Sphingolipids role in the regulation of inflammatory response: From leukocyte biology to bacterial infection

Chiricozzi

Loberto

Schiumarini

et al. 2018

Journal of Leukocyte Biology

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“…Sphingolipids, phospholipids, and cholesterol are the main constituents of membranes in eukaryotic cells (Zhang, Li, Becker, & Gulbins, ). Sphingolipids are fundamental for plasma membrane fluidity and architecture, and their metabolites such as ceramides (CER), sphingosine 1‐phosphate (S1P), and ceramide‐1‐phosphate (C1P) are regulators of cell proliferation, survival, inflammatory responses, and steroidogenesis (Presa et al, ).…”

Section: Introductionmentioning

confidence: 99%

Decreased Serum Levels of Sphingomyelins and Ceramides in Sickle Cell Disease Patients

Aslan

Kıraç

Kaya

et al. 2018

Lipids

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Limited data are available on the serum levels of different sphingomyelin (CerPCho) and ceramide (CER) species in sickle-cell disease (SCD). This study was aimed at identifying the levels of C16-C24 CerPCho and C16-C24 CER in serum obtained from SCD patients and controls. Circulating levels of neutral sphingomyelinase (N-SMase) activity, ceramide-1-phosphate (C1P), and sphingosine-1-phosphate (S1P) were also determined. Blood was collected from 35 hemoglobin (Hb)A volunteers and 45 homozygous HbSS patients. Serum levels of C16-C24 CerPCho and C16-C24 CER were determined by an optimized multiple reaction monitoring (MRM) method using ultrafast liquid chromatography (UFLC) coupled with tandem mass spectrometry (MS/MS). Serum activity of N-SMase was assayed by standard kit methods, and C1P and S1P levels were determined by enzyme-linked immunosorbent assay. A significant decrease was observed in the serum levels of C18-C24 CerPCho in patients with SCD compared to controls. No significant difference was found in C16 CerPCho levels between the two groups. Very-long-chain C22-C24 CER were significantly decreased in SCD, while long-chain C16-C20 CER levels showed no significant difference between SCD patients and controls. Significant positive correlation was found between the serum total cholesterol levels and C18-C24 CerPCho and C22-C24 CER in SCD patients. Patients with SCD had significantly elevated serum activity of N-SMase as well as increased circulating levels of C1P and S1P compared to controls. The decrease in serum levels of C18-C24 CerPCho in patients with SCD was accompanied by decreased levels of C22-C24 CER. Future studies are needed to understand the role of decreased CerPCho and CER in the pathophysiology of SCD.

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“…Development of cerk − / − mice and measurement of ceramide and C1P in their organs and blood identified important roles of CERK in regulating ceramide and C1P in cerebellar functions and immune responses (31,32). In addition, C1P was shown to control cell migration in different cell types, such as pancreatic cancer cells, macrophages, myoblasts and 3T3 pre-adipocytes (33). C1P can be dephosphorylated back to ceramide by the action of the ceramide-1-phosphate phosphatase (C1PP).…”

Section: Sphingolipid Metabolismmentioning

confidence: 99%

Sphingolipids in mitochondria

Hernández-Corbacho

Salama

Canals

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Sphingolipids are bioactive lipids found in cell membranes that exert a critical role in signal transduction. In recent years, it has become apparent that sphingolipids participate in growth, senescence, differentiation and apoptosis. The anabolism and catabolism of sphingolipids occurs in discrete subcellular locations and consist of a strictly regulated and interconnected network, with ceramide as the central hub. Altered sphingolipid metabolism is linked to several human diseases. Hence, an advanced knowledge of how and where sphingolipids are metabolized is of paramount importance in order to understand the role of sphingolipids in cellular functions. In this review, we provide an overview of sphingolipid metabolism. We focus on the distinct pathways of ceramide synthesis, highlighting the mitochondrial ceramide generation, transport of ceramide to mitochondria and its role in the regulation of mitochondrial-mediated apoptosis, mitophagy and implications to disease. We will discuss unanswered questions and exciting future directions.

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Regulation of cell migration and inflammation by ceramide 1-phosphate

Cited by 56 publications

References 128 publications

Sphingolipids role in the regulation of inflammatory response: From leukocyte biology to bacterial infection

Sphingolipids role in the regulation of inflammatory response: From leukocyte biology to bacterial infection

Decreased Serum Levels of Sphingomyelins and Ceramides in Sickle Cell Disease Patients

Sphingolipids in mitochondria

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