Regulation of cell differentiation via synergistic self-powered stimulation and degradation behavior of a biodegradable composite piezoelectric scaffold for cartilage tissue

Lai, Yen-Han; Chen, Yung-Hsin; Pal, Arnab; Chou, Syun-Hong; Chang, Shwu-Jen; Huang, E-Wen; Lin, Zong‐Hong; Chen, San‐Yuan

doi:10.1016/j.nanoen.2021.106545

Cited by 51 publications

(20 citation statements)

References 48 publications

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“…One of the most popular US-mediated catalysis is piezo-catalysis relied on piezoelectric materials 36 – 38 . A piezocatalytic reaction is generally due to piezoelectric polarization generated by piezoelectric materials triggering an electrochemical process.…”

Section: Resultsmentioning

confidence: 99%

Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy

et al. 2022

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Limited substrates content is a major hurdle dampening the antitumor effect of catalytic therapy. Herein, a two-dimensional interplanar heterojunction (FeOCl/FeOOH NSs) with ·OH generation under ultrasound irradiation is fabricated and utilized for catalytic cancer therapy. This interplanar heterojunction is prepared through replacing chlorine from iron oxychloride with hydroxyl. Benefiting from the longer hydroxyl bond length and enhanced affinity with water, the alkali replacement treatment integrates interplanar heterojunction synthesis and exfoliation in one step. In particular, a build-in electric field facilitated Z-scheme interplanar heterojunction is formed due to the aligning Fermi levels. The holes on the valence band of FeOCl have great ability to catalyze O2 evolution from H2O, meanwhile, the generated O2 is immediately and directly reduced to H2O2 by the electrons on the conductive band of FeOOH. The self-supplying H2O2 ability guarantees efficient ·OH generation via the Fenton-like reaction catalyzed by FeOCl/FeOOH NSs, which exhibits excellent anti-tumor performance.

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Section: Resultsmentioning

confidence: 99%

Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy

et al. 2022

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“…Condition simulation of in vivo mechanical loading is crucial in understanding the interaction between piezoelectric ES and tissue cells. A dynamic mechanical stimulus from a speaker (8 Ω, 1 W) [88] and linear motor [89] has been often incorporated to activate piezoelectric polymeric nanofibers in vitro. Variable frequency and intensity can be achieved to mimic the body motion through adjusting device parameters.…”

Section: Cell Traction Forcementioning

confidence: 99%

Electrical Stimulation Enabled via Electrospun Piezoelectric Polymeric Nanofibers for Tissue Regeneration

2022

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Electrical stimulation has demonstrated great effectiveness in the modulation of cell fate in vitro and regeneration therapy in vivo. Conventionally, the employment of electrical signal comes with the electrodes, battery, and connectors in an invasive fashion. This tedious procedure and possible infection hinder the translation of electrical stimulation technologies in regenerative therapy. Given electromechanical coupling and flexibility, piezoelectric polymers can overcome these limitations as they can serve as a self-powered stimulator via scavenging mechanical force from the organism and external stimuli wirelessly. Wireless electrical cue mediated by electrospun piezoelectric polymeric nanofibers constitutes a promising paradigm allowing the generation of localized electrical stimulation both in a noninvasive manner and at cell level. Recently, numerous studies based on electrospun piezoelectric nanofibers have been carried out in electrically regenerative therapy. In this review, brief introduction of piezoelectric polymer and electrospinning technology is elucidated first. Afterward, we highlight the activating strategies (e.g., cell traction, physiological activity, and ultrasound) of piezoelectric stimulation and the interaction of piezoelectric cue with nonelectrically/electrically excitable cells in regeneration medicine. Then, quantitative comparison of the electrical stimulation effects using various activating strategies on specific cell behavior and various cell types is outlined. Followingly, this review explores the present challenges in electrospun nanofiber-based piezoelectric stimulation for regeneration therapy and summarizes the methodologies which may be contributed to future efforts in this field for the reality of this technology in the clinical scene. In the end, a summary of this review and future perspectives toward electrospun nanofiber-based piezoelectric stimulation in tissue regeneration are elucidated.

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“…(d) Mechanism of stem cell proliferation mediated by the concomitant effect of piezoelectric stimulation and scaffold degradation. Reproduced with the permission from ref ( 62 ). Copyright 2021 Elsevier.…”

Section: Toward Sustainable Materials: Piezoelectric Nanofibers Based...mentioning

confidence: 99%

Enhancement and Function of the Piezoelectric Effect in Polymer Nanofibers

2022

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Conspectus The realization of intelligent, self-powered components and devices exploiting the piezoelectric effect at large scale might greatly contribute to improve our efficiency in using resources, albeit a profound redesign of the materials and architectures used in current electronic systems would be necessary. Piezoelectricity is a property of certain materials to generate an electrical bias in response to a mechanical deformation. This effect enables energy to be harvested from strain and vibration modes, and to sustain the power of actuators, transducers, and sensors in integrated networks, such as those necessary for the Internet of Thing. Polymers, combining structural flexibility with lightweight construction and ease of processing, have been largely used in this framework. In particular, the poly(vinylidene fluoride) [PVDF, (CH 2 CF 2 ) n ] and its copolymers exhibit strong piezoelectric response, are biocompatibile, can endure large strains and can be easily shaped in the form of nanomaterials. Confined geometries, improving crystal orientation and enhancing piezoelectricity enable the fabrication of piezoelectric nanogenerators, which satisfy many important technological requirements, such as conformability, cheap fabrication, self-powering, and operation with low-frequency mechanical inputs (Hz scale). This account reports on piezoelectric polymer nanofibers made by electrospinning. This technique enables the formation of high-aspect-ratio filaments, such as nanowires and nanofibers, through the application of high electric fields (i.e., on the order of hundreds of kV/m) and stretching forces to a polymeric solution. The solution might be charged with functional, organic or inorganic, fillers or dopants. The solution is then fed at a controlled flow rate through a metallic spinneret or forms a bath volume, from which nanofibers are delivered. Fibers are then collected onto metallic surfaces, and upon a change of the collecting geometry, they can form nonwovens, controlled arrays, or isolated features. Nanofibers show unique features, which include their versatility in terms of achievable chemical composition and chemico-physical properties. In addition, electrospinning can be up-scaled for industrial production. Insight into the energy generation mechanism and how the interaction among fibers can be used to enhance the piezoelectric performance are given in this paper, followed by an overview of fiber networks as the active layer in different device geometries for sensing, monitoring, and signal recognition. The use of biodegradable polymers, both natural and synthetic, as critically important building blocks of the roadmap for next-generation piezoelectric devices, is also discussed, with some representative examples. In particular, biodegradable materials have been utilized for applications related to life science, such as the realization of active scaffolds and of electronic devices to be placed in intim...

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Regulation of cell differentiation via synergistic self-powered stimulation and degradation behavior of a biodegradable composite piezoelectric scaffold for cartilage tissue

Cited by 51 publications

References 48 publications

Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy

Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy

Electrical Stimulation Enabled via Electrospun Piezoelectric Polymeric Nanofibers for Tissue Regeneration

Enhancement and Function of the Piezoelectric Effect in Polymer Nanofibers

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