Regulation of CD8 T cell by B-cells: A narrative review

Meerhaeghe, Tess Van; Néel, A.; Brouard, Sophie; Degauque, Nicolas

doi:10.3389/fimmu.2023.1125605

Cited by 6 publications

(5 citation statements)

References 99 publications

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“…We have noted a reduction in memory B cells, likely due to the inflammation-triggered extensive differentiation of plasma cells, leading to a decreased proportion of memory B cells [ 30 ]. Moreover, activated B cells can serve as antigen-presenting cells for CD4 and CD8 T cells, distinct from dendritic cells [ 38 , 39 ]. B cells can selectively present homologous antigens they have collected through surface immunoglobulins, enabling even low concentrations of antigens to be presented [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Causal role of immune cells in chronic periodontitis: a bidirectional Mendelian randomization study

Chen,

Jin,

Wang

et al. 2024

BMC Oral Health

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Background This study aims to explore the bidirectional causal relationship between immune cell phenotypes and chronic periodontitis using a Mendelian randomization framework. Materials and methods Through a two-sample Mendelian randomization analysis, this research examined genetic data related to 731 immune cell traits and chronic periodontitis. Instrumental variables were chosen based on their genetic links to either immune traits or periodontitis. Various statistical techniques, including MR-Egger regression, weighted median, and inverse-variance weighted (IVW) analysis, were employed to determine the causal connections. Results Predominantly using the IVW method, 26 distinct immune phenotypes were identified as potentially influencing periodontitis (P < 0.05). Conversely, periodontitis potentially affected 33 different immune phenotypes (P < 0.05). The results for pleiotropy and sensitivity tests were stable. However, these associations lost significance after adjusting for the False Discovery Rate. Conclusion This study uncovers a complex bidirectional causal relationship between certain immune cell phenotypes and chronic periodontitis, underscoring the intricate interaction between the immune system and the pathogenesis of periodontal disease.

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Section: Discussionmentioning

confidence: 99%

Causal role of immune cells in chronic periodontitis: a bidirectional Mendelian randomization study

Chen,

Jin,

Wang

et al. 2024

BMC Oral Health

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“…47 CD8+ T cells are the most potent and essential effectors regulating anticancer immune response. 48 CD8+ T cell deficiency in the TME contributes heavily to poor prognosis among PAAD patients. 49 Meanwhile, NETs encapsulate cancer cells, preventing the cytotoxic actions of immune cells, such as CD8+ T cells.…”

Section: Discussionmentioning

confidence: 99%

“…TME‐associated immune cells critically regulate tumor progression, which, in turn, can influence patient prognosis 47 . CD8+ T cells are the most potent and essential effectors regulating anticancer immune response 48 . CD8+ T cell deficiency in the TME contributes heavily to poor prognosis among PAAD patients 49 .…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analyses and experimental verification of NETs and an EMT gene signature for prognostic prediction, immunotherapy, and chemotherapy in pancreatic adenocarcinoma

Zhang,

Wang,

2023

Environmental Toxicology

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Pancreatic adenocarcinoma (PAAD) is an aggressive malignancy with high mortality and poor prognosis. Neutrophil extracellular traps (NETs) and the epithelial‐mesenchymal transition (EMT) significantly influence on the progression of various cancers. However, the underlying relevance of NETs‐ and EMT‐associated genes on the outcomes of patients with PAAD remains to be elucidated. Transcriptome RNA sequencing data, together with clinical information and single‐cell sequencing data of PAAD were collected from public databases. In the TCGA‐PAAD cohort, ssGSEA was used to calculate NET and EMT scores. WGCNA was used to determine the key gene modules. A risk model with eight NET‐ and EMT‐related genes (NERGs) was established using LASSO and multivariate Cox regression analysis. Patients in the reduced risk (RR) group showed better prognostic values compared with those in the elevated risk (ER) group. The prognostic model exhibited reliable and robust prediction when validated using an external database. The distributions of risk genes were explored in a single‐cell sequencing data set. Immune infiltration, immune cycle, and immune checkpoints were compared between the RR and ER groups. Moreover, potential chemotherapeutic drugs were examined. DCBLD2 was identified as a key gene in PAAD cell lines by qRT‐PCR, and was highly expressed in PAAD tissues. GSEA demonstrated that DCBLD2 induced the EMT. Transwell assays and western blotting showed that cell invasion and EMT induction were significantly reduced after DCBLD2 knockdown. Collectively, we constructed a prognosis model based on a NET and EMT gene signature, providing a valuable perspective for the prognostic evaluation and management of PAAD patient.

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“…A narrative review that covers the role of B cells in CD8 + T cell regulation was recently published that describes the importance of B cell activation for context-specific CD8 + T cell antigen presentation, and memory formation. Additionally, they cover the role Cells 2024, 13, 844 6 of 55 of B cells in promoting short-lived effector cells that are crucial for a productive immune response, and ultimately memory [52]. B cells make critical contributions to multiple aspects of a robust immune response which should not be overlooked.…”

Section: Migration Patterns Of Specific Immune Cellsmentioning

confidence: 99%

Immune Cell Migration to Cancer

Ryan,

Kim,

Lim

2024

Cells

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Immune cell migration is required for the development of an effective and robust immune response. This elegant process is regulated by both cellular and environmental factors, with variables such as immune cell state, anatomical location, and disease state that govern differences in migration patterns. In all cases, a major factor is the expression of cell surface receptors and their cognate ligands. Rapid adaptation to environmental conditions partly depends on intrinsic cellular immune factors that affect a cell’s ability to adjust to new environment. In this review, we discuss both myeloid and lymphoid cells and outline key determinants that govern immune cell migration, including molecules required for immune cell adhesion, modes of migration, chemotaxis, and specific chemokine signaling. Furthermore, we summarize tumor-specific elements that contribute to immune cell trafficking to cancer, while also exploring microenvironment factors that can alter these cellular dynamics within the tumor in both a pro and antitumor fashion. Specifically, we highlight the importance of the secretome in these later aspects. This review considers a myriad of factors that impact immune cell trajectory in cancer. We aim to highlight the immunotherapeutic targets that can be harnessed to achieve controlled immune trafficking to and within tumors.

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Regulation of CD8 T cell by B-cells: A narrative review

Cited by 6 publications

References 99 publications

Causal role of immune cells in chronic periodontitis: a bidirectional Mendelian randomization study

Causal role of immune cells in chronic periodontitis: a bidirectional Mendelian randomization study

Comprehensive analyses and experimental verification of NETs and an EMT gene signature for prognostic prediction, immunotherapy, and chemotherapy in pancreatic adenocarcinoma

Immune Cell Migration to Cancer

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