Regulation of CD47 expression by interferon-gamma in cancer cells

Ye, Zi-Han; Jiang, Xiaoming; Huang, Mu‐Yang; Xu, Yan; Yuan, Luo‐Wei; Huang, Can-Yu; Yu, Wei-Bang; Chen, Xiuping; Lu, Jin‐Jian

doi:10.1016/j.tranon.2021.101162

Cited by 22 publications

(19 citation statements)

References 50 publications

(65 reference statements)

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“…In line with this, the upregulation of CD47 by the IFN-g/JAK1/STAT1 pathway was reported by Ye et al in NCI-H1975 and A549 cells. 36 Supporting the role of IFN-g-induced CD47 in tumor metastasis, several investigators had also reported that IFN-g and CD47 could promote metastasis. 9,[37][38][39] As IFN-g can also induce the expression of PD-L1 in tumor cells, 40 the coordinate induction of CD47 and PD-L1 by IFN-g may underlie the pro-tumorigenic role of IFN-g during antitumor immunotherapy.…”

Section: Discussionmentioning

confidence: 93%

Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis

Jiao

et al. 2022

Molecular Therapy - Oncolytics

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Section: Discussionmentioning

confidence: 93%

Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis

Jiao

et al. 2022

Molecular Therapy - Oncolytics

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“…The CC membranes coated on the surface of the NLC were well-retained. CD47 on CC membranes can bind to the corresponding receptors on macrophages to avoid being phagocytized by macrophages (Zhy et al, 2021 ). Further, CD44 is a specific protein involved in interactions between cells on the surface of CC membranes, and affects the tumorigenesis and metastasis of tumor cells (Thakur et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Ligand-modified homologous targeted cancer cell membrane biomimetic nanostructured lipid carriers for glioma therapy

Chen

Cui

Hao³

et al. 2021

Drug Delivery

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The main treatment measure currently used for glioma treatment is chemotherapy; the biological barrier of solid tumors hinders the deep penetration of nanomedicines and limits anticancer therapy. Furthermore, the poor solubility of many chemotherapeutic drugs limits the efficacy of antitumor drugs. Therefore, improving the solubility of chemotherapeutic agents and drug delivery to tumor tissues through the blood–brain barrier (BBB) and blood–brain tumor barrier (BBTB) are major challenges in glioma treatment. Nanostructured lipid carriers (NLCs) have high drug loading capacity, high stability, and high in vivo safety; moreover, they can effectively improve the solubility of insoluble drugs. Therefore, in this study, we used solvent volatilization and ultrasonic melting methods to prepare dihydroartemisinin nanostructured lipid carrier (DHA-NLC). We further used the glioma C6 cancer cell (CC) membrane to encapsulate DHA-NLC owing to the homologous targeting mechanism of the CC membrane; however, the targeting ability of the CC membrane was weak. We accordingly used targeting ligands for modification, and developed a bionanostructured lipid carrier with BBB and BBTB penetration and tumor targeting abilities. The results showed that DHA-loaded NGR/CCNLC (asparagine–glycine–arginine, NGR) was highly targeted, could penetrate the BBB and BBTB, and showed good anti-tumor effects both in vitro and in vivo , which could effectively prolong the survival time of tumor-bearing mice. Thus, the use of DHA-loaded NGR/CCNLC is an effective strategy for glioma treatment and has the potential to treat glioma.

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“…In contrast, induction of CD47 on tumor cells, a prominent "don't-eat-me" signal, by IFN-γ relied on the JAK1-STAT1-IRF1 axis, which prevented phagocytosis of stressed tumor cells by macrophages. This finding was observed in various tumor cells, suggesting this is a universal immunosuppressive mechanism engaged by IFN-γ [118]. Furthermore, IFNs, in particular IFN-γ, can impact cellular metabolism by inducing tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO), which catabolizes essential amino acid tryptophan to kynurenine.…”

Section: The Ifn-jak-stat Axis In Ios (The Yin and Yang)mentioning

confidence: 93%

Bridging Radiotherapy to Immunotherapy: The IFN–JAK–STAT Axis

Shi

Bonner

2021

IJMS

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The unprecedented successes of immunotherapies (IOs) including immune checkpoint blockers (ICBs) and adoptive T-cell therapy (ACT) in patients with late-stage cancer provide proof-of-principle evidence that harnessing the immune system, in particular T cells, can be an effective approach to eradicate cancer. This instills strong interests in understanding the immunomodulatory effects of radiotherapy (RT), an area that was actually investigated more than a century ago but had been largely ignored for many decades. With the “newly” discovered immunogenic responses from RT, numerous endeavors have been undertaken to combine RT with IOs, in order to bolster anti-tumor immunity. However, the underlying mechanisms are not well defined, which is a subject of much investigation. We therefore conducted a systematic literature search on the molecular underpinnings of RT-induced immunomodulation and IOs, which identified the IFN–JAK–STAT pathway as a major regulator. Our further analysis of relevant studies revealed that the signaling strength and duration of this pathway in response to RT and IOs may determine eventual immunological outcomes. We propose that strategic targeting of this axis can boost the immunostimulatory effects of RT and radiosensitizing effects of IOs, thereby promoting the efficacy of combination therapy of RT and IOs.

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Regulation of CD47 expression by interferon-gamma in cancer cells

Abstract: Highlights IFN-γ up-regulated CD47 expression from transcriptional level. IFN-γ induced CD47 expression via JAK-STAT1-IRF1 pathway. The up-regulation of CD47 expression induced by IFN-γ was widespread among cancer.

Cited by 22 publications

References 50 publications

Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis

Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis

Ligand-modified homologous targeted cancer cell membrane biomimetic nanostructured lipid carriers for glioma therapy

Bridging Radiotherapy to Immunotherapy: The IFN–JAK–STAT Axis

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