Regulation of CD4+FOXP3+ T cells by CCL20/CCR6 axis in early unexplained recurrent miscarriage patients

Xx, Zhang; Xm, Kang; Zhao, Aihua

doi:10.4238/2015.august.7.24

Cited by 18 publications

(11 citation statements)

References 23 publications

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“…Compared with non‐pregnant women, peripheral CD4+CD25high Tregs are increased in healthy women early during pregnancy. However, they are decreased in women with (recurrent) miscarriages compared with normal early pregnancy, at a level comparable with that of non‐pregnant controls . This difference in Treg level can already be detected in non‐pregnant women with RM.…”

Section: Tregs In Rmmentioning

confidence: 73%

What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?

Craenmehr

Heidt

Eikmans

et al. 2016

HLA

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Couples of whom the woman has had a miscarriage have two major concerns: the cause and possible risk of recurrence. Unfortunately, a significant proportion of cases of recurrent miscarriage (RM) remain unexplained despite detailed investigation. Because data suggest that regulatory T cells (Treg) are involved in the maternal acceptance of the allogeneic foetus, RM could possibly be explained by a disturbance of the Treg network. The possible role of Tregs in RM is described in this review, as well as their potential application in diagnostics and therapeutic intervention trials.

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Section: Tregs In Rmmentioning

confidence: 73%

What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?

Craenmehr

Heidt

Eikmans

et al. 2016

HLA

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“…There is an increased occurrence of the following mutant genotypes and alleles of FOXP3 single nucleotide polymorphisms in women with uRPL compared with control women: rs2232365, rs3761548, rs5902434, and rs2294021 [172,173]. Moreover, FOXP3 expression was reduced in peripheral blood and decidua in women with uRPL compared with normal women [163]. In women with both uRPL and sporadic miscarriages, abnormalities in the normal function exerted by Tregs in uncomplicated pregnancies have been identified including: (1) higher numbers of Tregs from women with uRPL than normally fertile women were required to inhibit proliferation of CD4 + CD25effector cells in response to paternal allostimulation [56], and (2) the Helios+ Tregs-a supposed functionally active subset [174]-are reduced in the decidua of women with sporadic miscarriage with normal embryo karyotype [165].…”

Section: Tregsmentioning

confidence: 98%

“…Studies of Tregs in women with RPL are in substantial agreement with the findings obtained in animal models. Women with RPL have reduced Tregs in peripheral blood [162][163][164], as well as in their endometrium and decidua, compared with normal women [163,[165][166][167]. The reduction in Tregs in women with uRPL is paralleled by an increase in Th17 cells [166,168], suggesting the presence of an imbalance in Tregs/Th17 cells in uRPL [169][170][171].…”

Section: Tregsmentioning

confidence: 99%

Endometrial Immune Dysfunction in Recurrent Pregnancy Loss

Ticconi

Pietropolli

Simone

et al. 2019

IJMS

146

101

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Recurrent pregnancy loss (RPL) represents an unresolved problem for contemporary gynecology and obstetrics. In fact, it is not only a relevant complication of pregnancy, but is also a significant reproductive disorder affecting around 5% of couples desiring a child. The current knowledge on RPL is largely incomplete, since nearly 50% of RPL cases are still classified as unexplained. Emerging evidence indicates that the endometrium is a key tissue involved in the correct immunologic dialogue between the mother and the conceptus, which is a condition essential for the proper establishment and maintenance of a successful pregnancy. The immunologic events occurring at the maternal–fetal interface within the endometrium in early pregnancy are extremely complex and involve a large array of immune cells and molecules with immunoregulatory properties. A growing body of experimental studies suggests that endometrial immune dysregulation could be responsible for several, if not many, cases of RPL of unknown origin. The present article reviews the major immunologic pathways, cells, and molecular determinants involved in the endometrial dysfunction observed with specific application to RPL.

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“…Treg cells are consistently detected in NPC biopsies (Lau et al, ; Yip, Abdullah, Yusoff, & Seow, ). In addition to recruitment of DCs (Hong et al, ), CCL20/CCR6 axis mediates the migration of in CD4(+) FOXP3(+) regulatory T cells (Tregs) into inflammatory tissues (Cook et al, ; Zhang, Kang, & Zhao, ). Expression of CCL20 is positively correlated with Treg markers (FoxP3 and IL‐10) in multiple human cancers (Frick et al, ; Liu et al, ; Zhang, Qi, et al, ).…”

Section: Regulatory T Cellsmentioning

confidence: 99%

Rediscovery of NF‐κB signaling in nasopharyngeal carcinoma: How genetic defects of NF‐κB pathway interplay with EBV in driving oncogenesis?

Man

Cai

et al. 2018

Journal Cellular Physiology

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Nasopharyngeal carcinoma (NPC) is a unique EBV-associated subtype of head and neck cancer, which has the highest incidence in Southern China and eastern South Asia. The interaction between genetic risk factors and environmental challenge, have been considered to contribute to the development of nasopharyngeal carcinogenesis. Constitutive activation of NF-κB signaling has been seen in NPC tissues and is associated with unfavorable prognosis. Recently, several whole exome sequencing study consistently revealed that high frequency mutations of NF-κB pathway negative regulators is common in nasopharyngeal carcinoma, which reinforce the importance of NF-κB driving oncogenesis. This review focuses on the current state of research in role of NF-κB in NPC carcinogenesis. We summarized the newly identified loss of function (LOF) mutations on NF-κB negative regulators leading to it's activation bypass LMP-1 stimulation. We discussed the critical role of NF-κB activation in immortalization and transformation of nasopharygeal epithelium. We also depicted how NF-κB signaling mediated chronic inflammation contribute to persistent EBV infection, immune evasion of EBV infected cells, metabolic reprogramming, and cancer stem cells (CSCs) formation in NPC. Lastly, we discussed the clinical resonance of targeting NF-κB for NPC precise therapy.

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Regulation of CD4+FOXP3+ T cells by CCL20/CCR6 axis in early unexplained recurrent miscarriage patients

Cited by 18 publications

References 23 publications

What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?

What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?

Endometrial Immune Dysfunction in Recurrent Pregnancy Loss

Rediscovery of NF‐κB signaling in nasopharyngeal carcinoma: How genetic defects of NF‐κB pathway interplay with EBV in driving oncogenesis?

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