Regulation of Capillary Blood Flow: A New Concept

Harrison, David K.; Birkenhake, S.; Hagen, Nathan; Knauf, S.; Kessler, M.

doi:10.1007/978-1-4684-5643-1_65

Cited by 11 publications

(3 citation statements)

References 5 publications

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“…Tissue PO2 depends on processes such as convection, diffusion, and the O2 binding capacity of hemoglobin. Local regulatory mechanisms keep the tissue PO2 constant, especially during changes in capillary blood flow rate and in situations such as moderate hypoxia 20. The tissue PO2 can be measured without consideration of the tissue capillary flow rate or oxygen consumption.…”

Section: Discussionmentioning

confidence: 99%

Thermoregulatory response of anterolateral thigh flap compared with latissimus dorsi myocutaneous flap: An evaluation of flaps cutaneous flow and velocity due to thermal stress

Rahmanian-Schwarz¹,

Schiefer²,

Amr³

et al. 2011

Microsurgery

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Section: Discussionmentioning

confidence: 99%

Thermoregulatory response of anterolateral thigh flap compared with latissimus dorsi myocutaneous flap: An evaluation of flaps cutaneous flow and velocity due to thermal stress

Rahmanian-Schwarz¹,

Schiefer²,

Amr³

et al. 2011

Microsurgery

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“…It is kept constant by local regulatory mechanisms, especially during changes in capillary blood flow rate and also in situations such as moderate hypoxia in chronic anemia. 28 The same PO 2 can be measured regardless of whether the tissue capillary flow rate and oxygen consumption are high or low. However, O2C determination of intracapillary hemoglobin oxygenation provides data on the intracapillary hemoglobin saturation and local blood flow rate.…”

Section: Discussionmentioning

confidence: 99%

Nutritive perfusion at donor site after microvascular fibula transfer

et al. 2003

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There are many reports on the versatility of the fibular flap, but only a few studies have reported on the morbidity, and none on the nutritive perfusion, of the donor site. This study describes for the first time the quantitative investigation of nutritive perfusion at the donor site after osteomyo-cutaneous fibula transfer. Tissue nutrition of the lower leg was measured in 25 patients by micro-lightguide spectrophotometry and laser Doppler flowmetry. In a standardized examination, hemoglobin oxygenation and blood flow of the donor leg and the contralateral leg (intraindividual control) were measured at the nutritive region of the peroneal artery (I), posterior tibial artery (II), and anterior tibial artery (III). In the operated leg, blood flow was significantly reduced in region I with the sacrificed peroneal artery, and significantly increased in region II and III, probably for compensation (P = 0.03). Decreased hemoglobin oxygenation and blood flow of the peroneal region at the donor site were without significance in comparison to the control leg (P = 0.55 and P = 0.35, respectively). Decreased nutritive perfusion at the donor site was below the threshold of clinical manifestation, and supports the low donor site morbidity following fibular grafting.

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“…Попытки многих исследователей выяснить закономерности построения капиллярной сети даже с помощью компьютерного анализа ни к чему не привели. Был констатирован крайне неупорядоченный гетерогенный порядок расположения капилляров в коре головного мозга и в мышцах животных, чрезвычайно разнообразное распределение скоростей кровотока, равно как и распределение гематокрита в капиллярах [17,18]. Именно поэтому все вышеизложенные исследования о функциональной изменчивости капилляров в дополнение к современным литературным данным позволяют выдвинуть вполне обоснованную ги-потезу, что кровообращение в капиллярах не подчиняется непосредственной нервной регуляции кровотока в каждом из миллиардов капилляров, а зависит от стохастического (непредсказуемого) закона, основанного на ряде случайных влияний на капиллярный кровоток.…”

Section: стохастический закон микроциркуляцииunclassified

Modern Medical Problems of Microcirculation and Hypoxic Syndrome

Ivanov

2015

Annals RAMS

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In this paper long known problems of microcirculation are shown, which were solved only during the last 40 years. They are concerned with the velocity and character of the capillary blood flow, the regulation of the capillary blood flow, the role of various vessels in the oxygen transport, the role of leukocytes in physiology and pathology of the capillary blood flow, with the special features of the function of lungs in supplying the whole organism with oxygen and with bioenergetic laws in the development of an organism adaptation to hypoxia. Here we considered a number of the most important medical problems of microcirculation and hypoxic syndrome. A relatively new factor in the capillary circulation is the fact that in the brain and heart capillaries there are sites with pO2 close to zero. They show that the capillary circulation has no central nervous regulation of the blood flow. The blood flow in these organs obeys only occasional oscillations. The new fact is that Krogh’s rule about metabolism and oxygen exchange occurring only in the capillaries is abandoned. It is shown that almost 30% of consumed oxygen is delivered to the brain via arterioles, which changes our relation to the capillary circulation as a unique mechanism of the tissue supply with oxygen. The new fact is also the mass adhesion of leukocytes to the walls of microvessels, which results in the occlusion of the vessels followed by the development of the heart and brain ischemia. It was shown for the first time that contrary to previous ideas the alveoli in the lungs are supplied with blood from a powerful network of large microvessels from 20 to 50 μm in diameter rather than from thin arterioles. They make possible the passage of 6–12 l of the blood in the norm and during stressed muscle activity — up to 18–23 l of blood per minute. The principle is substantiated that during hypoxia only normal supply of an organism with oxygen may result in a complete adaptation of an organism to the deficit of oxygen.

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Regulation of Capillary Blood Flow: A New Concept

Cited by 11 publications

References 5 publications

Thermoregulatory response of anterolateral thigh flap compared with latissimus dorsi myocutaneous flap: An evaluation of flaps cutaneous flow and velocity due to thermal stress

Thermoregulatory response of anterolateral thigh flap compared with latissimus dorsi myocutaneous flap: An evaluation of flaps cutaneous flow and velocity due to thermal stress

Nutritive perfusion at donor site after microvascular fibula transfer

Modern Medical Problems of Microcirculation and Hypoxic Syndrome

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