Regulation of cancer progression by circRNA and functional proteins

Chen, Junhong; Gu, Jie; Tang, Mengtian; Liao, Zhiqiang; Tang, Rui; Zhou, Lianqing; Su, Min; Jiang, Jiarui; Hu, Yingbin; Chen, Yongyi; Zhou, Yujuan; Liao, Qianjin; Xiong, Wei; Zhou, Jinsong; Tang, Yue; Nie, Shaolin

doi:10.1002/jcp.30608

Cited by 31 publications

(12 citation statements)

References 137 publications

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“…Although circRNA has a unique closed-loop structure, it still contains miRNA binding sites, which endows it with potential as a miRNA sponge ( 60 – 62 ). This property suggests that circRNAs can inhibit the activity of mature miRNAs, increase the level of endogenous targets, and inhibit miRNAs to regulate the expression of downstream genes ( 63 , 64 ). For example, CIRS-7, which contains more than 70 miRNA seed regions, is considered a ceRNA and plays an important role in a variety of cancers ( 65 , 66 ).…”

Section: Mirna Spongementioning

confidence: 99%

Mechanism underlying circRNA dysregulation in the TME of digestive system cancer

Zhang

et al. 2022

Front. Immunol.

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Circular RNAs (circRNAs) are a new series of noncoding RNAs (ncRNAs) that have been reported to be expressed in eukaryotic cells and have a variety of biological functions in the regulation of cancer pathogenesis and progression. The TME, as a microscopic ecological environment, consists of a variety of cells, including tumor cells, immune cells and other normal cells, ECM and a large number of signaling molecules. The crosstalk between circRNAs and the TME plays a complicated role in affecting the malignant behaviors of digestive system cancers. Herein, we summarize the mechanisms underlying aberrant circRNA expression in the TME of the digestive system cancers, including immune surveillance, angiogenesis, EMT, and ECM remodelling. The regulation of the TME by circRNA is expected to be a new therapeutic method.

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Section: Mirna Spongementioning

confidence: 99%

Mechanism underlying circRNA dysregulation in the TME of digestive system cancer

Zhang

et al. 2022

Front. Immunol.

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“…Currently, circular RNAs (circRNAs) that have been detected in human tissues have been shown to be involved in different cellular processes, including senescence, cell proliferation, and apoptosis (3,4). CircRNAs are stable, diverse, and conserved RNA molecules that play indispensable roles in RNA interaction networks (4).…”

Section: Original Articlementioning

confidence: 99%

Circular RNA ZFR promotes cell cycle arrest and apoptosis of colorectal cancer cells via the miR-147a/CACUL1 axis

Tan¹,

Wang²,

Kong³

2022

J Gastrointest Oncol

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Background: Colorectal cancer (CC) is one of the most prevalent malignancies worldwide. Nonetheless, its pathogenicity and molecular mechanisms have not been completely elucidated yet. The potential clinical value of circular RNAs (circRNAs) in tumor diagnosis, treatment, and prognosis has received considerable attention. Methods: Here, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) examined the levels of circular ZFR (circZFR) in CC cells. The expression of circZFR was knocked down in CC cells and cell viability was detected using Cell Counting Kit-8 (CCK-8) and colony formation assays. Cell cycle progression was assessed by flow cytometry and the expression levels of cyclin-associated proteins were detected by western blot analysis. The transferase dUTP nick end labeling (TUNEL) assay was used to detect apoptosis and western blot analysis was used to evaluate the expression levels of apoptosis-associated proteins. Subsequently, the interactions between circZFR and microRNA (miR)-147a and between miR-147a and CDK2 associated cullin domain 1 (CACUL1) were predicted by the Encyclopedia of RNA Interactomes database and verified by luciferase reporter assays. Finally, plasmid transfection, CCK-8, and flow cytometry assays were used to explore the associated mechanism of action. Results: CircZFR was highly expressed in CC cell lines. Interference with its expression inhibited proliferation and induced G1/S cell cycle arrest and apoptosis in CC cells. The expression levels of miR-147a and CACUL1 were decreased and increased, respectively, in CC cells. These data demonstrated that circZFR could target miR-147a and CACUL1 to regulate the cell cycle and apoptosis of CC cells and, ultimately, promote the progression of CC. Conclusions: Knockdown of the expression of circZFR upregulated miR-147a expression and reduced CACUL1 expression levels, thereby inhibiting the proliferation of CC cells and inducing cell cycle arrest and apoptosis.

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“…CircRNAs can bind directly to RBPs to form RNA-protein complexes to regulate RBPs and further affect the expression and biology of downstream proteins ( Huang et al, 2020 ; Feng J. et al, 2021 ; Chen J. et al, 2021 ; Xu et al, 2021 ). Muscleblind-like (MBL) binds to exon 2 of its parental gene and induces cyclization to form circMbl, which also binds to MBL to reduce MBL abundance, thereby reducing circMbl production ( Ashwal-Fluss et al, 2014 ).…”

Section: Acts As a Competitive Endogenous Rnamentioning

confidence: 99%

Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors

Shen

Liu

et al. 2022

Front. Genet.

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Circular RNAs (circRNAs) are non-coding RNAs with covalent closed-loop structures and are widely distributed in eukaryotes, conserved and stable as well as tissue-specific. Malignant solid tumors pose a serious health risk to children and are one of the leading causes of pediatric mortality. Studies have shown that circRNAs play an important regulatory role in the development of childhood malignant solid tumors, hence are potential biomarkers and therapeutic targets for tumors. This paper reviews the biological characteristics and functions of circRNAs as well as the research progress related to childhood malignant solid tumors.

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Regulation of cancer progression by circRNA and functional proteins

Cited by 31 publications

References 137 publications

Mechanism underlying circRNA dysregulation in the TME of digestive system cancer

Mechanism underlying circRNA dysregulation in the TME of digestive system cancer

Circular RNA ZFR promotes cell cycle arrest and apoptosis of colorectal cancer cells via the miR-147a/CACUL1 axis

Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors

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