Regulation of cancer cell lipid metabolism and oxidative phosphorylation by microenvironmental acidosis
Michala G. Rolver,
Marc Severin,
Stine F. Pedersen
Abstract:The expansion of cancer cell mass in solid tumors generates a harsh environment characterized by dynamically varying levels of acidosis, hypoxia and nutrient deprivation. Because acidosis inhibits glycolytic metabolism and hypoxia inhibits oxidative phosphorylation, cancer cells that survive and grow in these environments must rewire their metabolism and develop a high degree of metabolic plasticity to meet their energetic and biosynthetic demands. Cancer cells frequently upregulate pathways enabling the uptak… Show more
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