Abstract:c‐Myb is a transcription factor and proto‐oncogene that is important for hematopoietic cell development. This gene is predominately expressed in progenitor cells of adult bone marrow and down regulated during differentiation. Through gene knockout experimentation, the importance for c‐myb in developing cells has been determined. Null mutants show lethality in certain blood cell lines, strengthening the ideas that c‐myb plays an important role in cell line differentiation. Specifically, in murine embryonic cell… Show more
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