Regulation of body fat mass by the gut microbiota: Possible mediation by the brain

Schéle, Erik; Grahnemo, Louise; Anesten, Fredrik; Hallén, Anna; Bäckhed, Fredrik; Jansson, John‐Olov

doi:10.1016/j.peptides.2015.03.027

Cited by 26 publications

(21 citation statements)

References 73 publications

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“…Obesity itself is linked to an altered gut microbiota with an opposite ratio of Firmicutes to Bacteroidetes than more lean individuals (Schele et al, 2015). Hence there is the possibility that prenatal microbiota manipulation can have long-term effects on the health of the infant.…”

Section: Perturbation Of the Prenatal Microbiotamentioning

confidence: 99%

Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

et al. 2017

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Section: Perturbation Of the Prenatal Microbiotamentioning

confidence: 99%

Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

et al. 2017

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“…In addition, it is thought that people may become obese through different pathways that possibly are independent of caloric balance, e.g. brain mediation of body fat mass, diminution of muscle mass and strength, as well as gut microbiota [53–55]. Therefore, it would be more ethical to use a ‘cause of obesity’ concept that does not transfer total responsibility to the individual.…”

Section: Possible Consequences Of Using Conceptmentioning

confidence: 99%

“…Therefore, it may be also possible that diet composition affects the whole digestive process and, hence, fat production and accumulation [53,71]. Given that obesity is an ‘abnormal or excessive fat accumulation that may impair health’ [1], it would appear appropriate to focus on the details of fat production and accumulation.…”

Section: An Alternative Approach To Causes For Obesitymentioning

confidence: 99%

Is the calorie concept a real solution to the obesity epidemic?

Camacho

Ruppel

2017

Global Health Action

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Background: The obesity epidemic has been growing steadily across the whole world, and so far not a single country has been able to reverse it. The cause of obesity is stated by the World Health Organization as an energy imbalance between calories consumed and calories expended. However, growing evidence suggests that the calorie imbalance concept may not be sufficient to manage and reverse the obesity epidemic. Objective: To discuss the use of the calorie imbalance concept and its elements as a tool for weight management as well as its possible negative consequences and implications for public health, with the aim to point toward the need of an updated concept for causes of obesity. This update should guide public health interventions more efficiently to limit obesity by preventing weight gain or promoting weight loss.Methods: This is a literature reviews based on a semi-structured approach to determine the material to be examined.Results: After revisiting general facts about fat generation and accumulation, we propose an updated concept for the causes of obesity including diet composition and hormonal regulation of fat metabolism.Conclusions: We discuss how this updated concept could benefit the overall efficiency of strategies against obesity, and hypothesize how potential resistance to adopting this new view could be lowered.

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“…In male mice, prenatal lead and early-life cadmium exposure have been shown to alter gut microbiota and lead to increases in adult body weight [70] and fat mass [72]. Pathways epigenetically perturbed by cadmium and lead, especially the pathways altered in obesity, will be important for understanding its pathogenesis potentially via the microbiota–gut–brain axis [107–109] in childhood. We summarize these putative relationships in Figure 1.…”

Section: Potential Mechanisms By Which Cadmium and Lead May Alter Obesimentioning

confidence: 99%

Epigenetics, Obesity and Early-Life Cadmium or Lead Exposure

et al. 2016

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Obesity is a complex and multifactorial disease, which likely comprises multiple subtypes. Emerging data have linked chemical exposures to obesity. As organismal response to environmental exposures includes altered gene expression, identifying the regulatory epigenetic changes involved would be key to understanding the path from exposure to phenotype and provide new tools for exposure detection and risk assessment. In this report, we summarize published data linking early-life exposure to the heavy metals, cadmium and lead, to obesity. We also discuss potential mechanisms, as well as the need for complete coverage in epigenetic screening to fully identify alterations. The keys to understanding how metal exposure contributes to obesity are improved assessment of exposure and comprehensive establishment of epigenetic profiles that may serve as markers for exposures.

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Regulation of body fat mass by the gut microbiota: Possible mediation by the brain

Cited by 26 publications

References 73 publications

Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

Is the calorie concept a real solution to the obesity epidemic?

Epigenetics, Obesity and Early-Life Cadmium or Lead Exposure

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