Regulation of blood flow in single capillaries

Pc, Johnson; Wayland, Harold

doi:10.1152/ajplegacy.1967.212.6.1405

Cited by 158 publications

(41 citation statements)

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“…A tissue area can also be bypassed through arteriovenous anastomoses, the blood being then diverted directly from the arterioles into venules. Blood flow through a capillary network is highly variable, can be completely stopped or even sometimes reversing direction [18,19].…”

Section: Functional Anatomy Of the Peritoneal Microvasculaturementioning

confidence: 99%

Functional vascular anatomy of the peritoneum in health and disease

Solaß

Horvath

Struller

et al. 2019

Pleura and Peritoneum

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Abstract:The peritoneum consists of a layer of mesothelial cells on a connective tissue base which is perfused with circulatory and lymphatic vessels. Total effective blood flow to the human peritoneum is estimated between 60 and 100 mL/min, representing 1-2 % of the cardiac outflow. The parietal peritoneum accounts for about 30 % of the peritoneal surface (anterior abdominal wall 4 %) and is vascularized from the circumflex, iliac, lumbar, intercostal, and epigastric arteries, giving rise to a quadrangular network of large, parallel blood vessels and their perpendicular offshoots. Parietal vessels drain into the inferior vena cava. The visceral peritoneum accounts for 70 % of the peritoneal surface and derives its blood supply from the three major arteries that supply the splanchnic organs, celiac and superior and inferior mesenteric. These vessels give rise to smaller arteries that anastomose extensively. The visceral peritoneum drains into the portal vein. Drugs absorbed are subject to firstpass hepatic metabolism. Peritoneal inflammation and cancer invasion induce neoangiogenesis, leading to the development of an important microvascular network. Anatomy of neovessels is abnormal and characterized by large size, varying diameter, convolution and blood extravasation. Neovessels have a defective ultrastructure: formation of large "mother vessels" requires degradation of venular and capillary basement membranes. Mother vessels give birth to numerous "daughter vessels". Diffuse neoangiogenesis can be observed before appearance of macroscopic peritoneal metastasis. Multiplication of the peritoneal capillary surface by neoangiogenesis surface increases the part of cardiac outflow directed to the peritoneum.

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Section: Functional Anatomy Of the Peritoneal Microvasculaturementioning

confidence: 99%

Functional vascular anatomy of the peritoneum in health and disease

Solaß

Horvath

Struller

et al. 2019

Pleura and Peritoneum

View full text Add to dashboard Cite

show abstract

“…66469 " 71 When intravascular pressure is elevated, the myogenic response leads to a sustained shortening of the vascular smooth muscle. The sustained shortening may reflect the special geometry of smooth muscle in the arterioles and the dependence of circumferential tension on both the vessel radius and transmural pressure T = Pr (Law of Laplace).…”

mentioning

confidence: 99%

Autoregulation of blood flow.

Johnson¹

1986

Circulation Research

359

188

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“…Previous investigations of erythrocyte velocity in small blood vessels do not concern themselves with the cerebral circulation (1)(2)(3)(4)(5)(6)(7)(8). In studies of other vascular beds a rhythmic change in velocity has sometimes been observed (2,3,(5)(6)(7)(8); however, with the exception of the pulmonary microcirculation (7,8), these changes have rarely (2,6) been ascribed to the cardiac cycle and often have a much lower periodicity of approximately 5 cycles /min (3,5). Recently, S vanes and Zweifach (9) observed occasional pulsatile movements at the end of a column of erythrocytes protruding into the orifice of an occluded arteriole.…”

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confidence: 99%

Erythrocyte Velocity and a Velocity Pulse in Minute Blood Vessels on the Surface of the Mouse Brain

Rosenblum

1969

Circulation Research

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High-speed microcinematography of vessels in the subarachnoid space of the anesthetized mouse was used to measure the velocity of erythrocytes in arterioles and venules less than 30/i in diameter. Within arterioles the velocity averaged 3.5 mm/sec, while in venules an average value of 1.9 mm/sec was obtained. A rhythmic alteration in velocity was often observed in the arterioles and was seen occasionally in venules. This cyclical change in velocity was termed the "velocity pulse." The frequency of the velocity pulse was virtually identical to that of the peripheral pulse and is believed to result from a propagation of that pulse into the microcirculation. The velocity pulse was not recognizable in vessels 5/x to 10/A wide. In vessels lOfju to 30yx in diameter, the velocity pulse was not accompanied by changes in the width of the vessels.

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Regulation of blood flow in single capillaries

Cited by 158 publications

References 0 publications

Functional vascular anatomy of the peritoneum in health and disease

Functional vascular anatomy of the peritoneum in health and disease

Autoregulation of blood flow.

Erythrocyte Velocity and a Velocity Pulse in Minute Blood Vessels on the Surface of the Mouse Brain

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