Regulation of astrocyte cell biology by the cAMP/protein kinase A signaling pathway

Huneycutt, Brandon S.; Benveniste, Etty N.

doi:10.1016/0960-5428(95)00022-t

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…Since 5‐HT 7 receptors are positively linked to cAMP accumulation, cellular events associated with the cAMP/protein kinase A pathway in glial cells may be considered as candidate functions of these receptors. Interestingly enough, among these are the release of neurotrophic factors and of inflammatory cytokines ( Huneycutt & Benveniste, 1995 ).…”

Section: Discussionmentioning

confidence: 99%

Functional expression of the serotonin 5‐HT₇ receptor in human glioblastoma cell lines

Mahé

Bernhard

Bobirnac

et al. 2004

British J Pharmacology

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1 Serotonin 5-HT 7 receptors are present in astrocytes. Understanding their role in this type of cell would greatly benefit from the identification of astroglial cell lines expressing this receptor type. 2 The aim of the present study was to assess the expression of native 5-HT 7 receptors and 5-HT 7 receptor mRNA in a number of human glioblastoma cell lines, by means of cAMP measurements, Western blot analysis and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis.

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Section: Discussionmentioning

confidence: 99%

Functional expression of the serotonin 5‐HT₇ receptor in human glioblastoma cell lines

Mahé

Bernhard

Bobirnac

et al. 2004

British J Pharmacology

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“…The high z-score for protein kinase A in the astrocytes is interesting since this pathway is critical for astrocyte responsiveness to the environment, both for neural support functions and inflammation. [14,27] The neural cells displayed a similar profile to the astrocytes with some exceptions, with more upregulated PI3K/AKT and neuregulin signaling and downregulated peroxisome proliferator-activated receptors (PPAR)/retinoid X receptor (RXR) and protein kinase A signaling, along with a total absence of expressed proteins in the Sphingosine-1-phosphate and ceramide signaling pathways. Characterizing the human neurovascular unit (NVU) in vitro.…”

Section: Proteomic Characterization Of Individual Primary Cell Types mentioning

confidence: 99%

Proteomic and Metabolomic Characterization of Human Neurovascular Unit Cells in Response to Methamphetamine

et al. 2020

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The functional state of the neurovascular unit (NVU), composed of the blood–brain barrier and the perivasculature that forms a dynamic interface between the blood and the central nervous system (CNS), plays a central role in the control of brain homeostasis and is strongly affected by CNS drugs. Human primary brain microvascular endothelium, astrocyte, pericyte, and neural cell cultures are often used to study NVU barrier functions as well as drug transport and efficacy; however, the proteomic and metabolomic responses of these different cell types are not well characterized. Culturing each cell type separately, using deep coverage proteomic analysis and characterization of the secreted metabolome, as well as measurements of mitochondrial activity, the responses of these cells under baseline conditions and when exposed to the NVU‐impairing stimulant methamphetamine (Meth) are analyzed. These studies define the previously unknown metabolic and proteomic profiles of human brain pericytes and lead to improved characterization of the phenotype of each of the NVU cell types as well as cell‐specific metabolic and proteomic responses to Meth.

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“…Its signaling pathway exists in all types of cells and contributes to numerous biological processes, such as cell growth, differentiation, death, gene expression, inflammatory cytokine secretion, and neurotransmission (5–7) in the central nervous system (CNS). Upon stimulation, cAMP synthesis and its degradation are tightly regulated by adenylyl cyclases (ACs) and cyclic nucleotide phosphodiesterases (PDEs), respectively (6).…”

Section: Introductionmentioning

confidence: 99%

Role of cyclic AMP in the eye with glaucoma

Shim

Kim

2017

BMB Reports

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Glaucoma is characterized by a slow and progressive degeneration of the optic nerve, including retinal ganglion cell (RGC) axons in the optic nerve head (ONH), leading to visual impairment. Despite its high prevalence, the biological basis of glaucoma pathogenesis still is not yet fully understood, and the factors contributing to its progression are currently not well characterized. Intraocular pressure (IOP) is the only modifiable risk factor, and reduction of IOP is the standard treatment for glaucoma. However, lowering IOP itself is not always effective for preserving visual function in patients with primary open-angle glaucoma. The second messenger cyclic adenosine 3′,5′-monophosphate (cAMP) regulates numerous biological processes in the central nervous system including the retina and the optic nerve. Although recent studies revealed that cAMP generated by adenylyl cyclases (ACs) is important in regulating aqueous humor dynamics in ocular tissues, such as the ciliary body and trabecular meshwork, as well as cell death and growth in the retina and optic nerve, the functional role and significance of cAMP in glaucoma remain to be elucidated. In this review, we will discuss the functional role of cAMP in aqueous humor dynamics and IOP regulation, and review the current medications, which are related to the cAMP signaling pathway, for glaucoma treatment. Also, we will further focus on cAMP signaling in RGC growth and regeneration by soluble AC as well as ONH astrocytes by transmembrane ACs to understand its potential role in the pathogenesis of glaucoma neurodegeneration

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Regulation of astrocyte cell biology by the cAMP/protein kinase A signaling pathway

Cited by 8 publications

References 39 publications

Functional expression of the serotonin 5‐HT₇ receptor in human glioblastoma cell lines

Functional expression of the serotonin 5‐HT₇ receptor in human glioblastoma cell lines

Proteomic and Metabolomic Characterization of Human Neurovascular Unit Cells in Response to Methamphetamine

Role of cyclic AMP in the eye with glaucoma

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Regulation of astrocyte cell biology by the cAMP/protein kinase A signaling pathway

Cited by 8 publications

References 39 publications

Functional expression of the serotonin 5‐HT7 receptor in human glioblastoma cell lines

Functional expression of the serotonin 5‐HT7 receptor in human glioblastoma cell lines

Proteomic and Metabolomic Characterization of Human Neurovascular Unit Cells in Response to Methamphetamine

Role of cyclic AMP in the eye with glaucoma

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Functional expression of the serotonin 5‐HT₇ receptor in human glioblastoma cell lines

Functional expression of the serotonin 5‐HT₇ receptor in human glioblastoma cell lines