Regulation of apoptosis proteins in cancer cells by ubiquitin

Proteasome inhibition induces hepatic stellate cell apoptosis

“…32 Consistent with its effects in other cell types, [43][44][45] bortezomib enhanced TRAIL R2/DR5 expression in LX-2 cells. However, incubation with a TRAIL-R2-Fc, which binds and neutralizes TRAIL, did not attenuate apoptosis.…”

Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells

“…Cooperation of betulinic acid and TRAIL S Fulda et al detected by enzymatic assay did not always correlate with caspase cleavage as determined by Western blot analysis, which may be related to the fact that caspase cleavage products are subject to degradation by the proteasome (Zhang et al, 2004). Together, this set of experiments demonstrates that BetA and TRAIL cooperated to activate effector caspases.…”

Mitochondrial Impairment Mediates Cytolysis in Anthrax Lethal Toxin-Treated Murine Macrophages

“…[18][19][20] However, it is unclear how proteasome inhibitors block LT toxicity. Proteasomal degradation of protective factors, such as XIAP, controls cell death mediated by TNF-α or Trail, 21 and it is conceivable that protective factors are also targeted by proteasomes during LT killing of murine macrophages. The proteasome system, along with the lysosomal system, makes up the major cellular protein degradation machinery.…”