Regulation of apoptosis in the immune system

Krammer, Peter H.; Behrmann, Iris; Daniel, Peter T.; Dhein, Jens; Debatin, Klaus‐Michael

doi:10.1016/0952-7915(94)90102-3

Cited by 303 publications

(169 citation statements)

References 136 publications

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“…Apoptosis in sperm may also be initiated by ROS-independent pathways involving the cell surface protein Fas (87). Fas is a type I membrane protein that belongs to the tumor necrosis factor-nerve growth factor receptor family and mediates apoptosis (93). When Fas ligand or agonistic anti-Fas antibody binds to Fas, apoptosis occurs (94).…”

Section: Agarwal Ros and Human Reproduction Fertil Steril 2003mentioning

confidence: 99%

Role of reactive oxygen species in the pathophysiology of human reproduction

Agarwal

Saleh

Bedaiwy

2003

Fertility and Sterility

1,276

909

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Objective: To summarize the role of reactive oxygen species (ROS) in the pathophysiology of human reproduction. Design: Review of literature. Setting: Fertility research center and obstetrics and gynecology department in a tertiary care facility. Result(s): ROS plays an essential role in the pathogenesis of many reproductive processes. In male-factor infertility, oxidative stress attacks the fluidity of the sperm plasma membrane and the integrity of DNA in the sperm nucleus. Reactive oxygen species induced DNA damage may accelerate the process of germ cell apoptosis, leading to the decline in sperm counts associated with male infertility. ROS mediated female fertility disorders share many pathogenic similarities with the ones on the male side. These similarities include a potential role in the pathophysiology of endometriosis and unexplained infertility. High follicular fluid ROS levels are associated with negative IVF outcomes, particularly in smokers. Moreover, oxidative stress may be responsible in hydrosalpingeal fluid mediated embryotoxicity as well as poor in vitro embryonic development. Conclusion(s):High levels of ROS are detrimental to the fertility potential both in natural and assisted conception states. (Fertil Steril 2003;79:829 -43.

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Section: Agarwal Ros and Human Reproduction Fertil Steril 2003mentioning

confidence: 99%

Role of reactive oxygen species in the pathophysiology of human reproduction

Agarwal

Saleh

Bedaiwy

2003

Fertility and Sterility

1,276

909

View full text Add to dashboard Cite

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“…The (patho)-physiology of the prototype death receptors TNF-R1 and CD95 has been intensively studied and described in several reviews. 1,[19][20][21][22] In contrast, the physiological relevance of the new death receptors is largely unknown. TRAMP, also called DR3, WSL-1, APO-3 or LARD, and the recently characterized death receptor-6 (DR6) are both structurally and functionally similar to TNF-R1, because their overexpression leads to nuclear factor-kappa B (NF-B) activation and apoptosis.…”

Section: Structure and Function Of Death Receptorsmentioning

confidence: 99%

“…107 CD95 triggering either by agonistic antibodies or its ligand revealed that a broad variety of non-malignant cells are susceptible to CD95-triggered apoptosis. 1,19,20 This may lead to immune suppression, since physiological signaling via CD95 is involved in immune tolerance both in the T and B cell compartment. [108][109][110][111] Interestingly, co-stimulatory signals such as via B7/CD28 112,113 or CD2/CD58, eg by dendritic cells, 114 can overcome this deleterious effect of immune cell depletion by death receptor signaling.…”

Section: Death Ligands In Cancer Therapymentioning

confidence: 99%

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The kiss of death: promises and failures of death receptors and ligands in cancer therapy

et al. 2001

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“…Apoptosis or programmed cell death plays an important role in development, in tissue and immune homeostasis, and in the elimination of virus-infected cells and tumor cells (1)(2)(3)(4). There are two general, interconnected apoptosis pathways.…”

Section: Introductionmentioning

confidence: 99%

Constitutively Activated Nuclear Factor-κB, but not Induced NF-κB, Leads to TRAIL Resistance by Up-Regulation of X-Linked Inhibitor of Apoptosis Protein in Human Cancer Cells

Braeuer

Büneker

Mohr

et al. 2006

Molecular Cancer Research

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The tumor necrosis factor -related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in most, but not all, cancer cells. The molecular factors regulating the sensitivity to TRAIL are still incompletely understood. The transcription factor nuclear factor-KB (NF-KB) has been implicated, but its exact role is controversial. We studied different cell lines displaying varying responses to TRAIL and found that TRAIL can activate NF-KB in all our cancer cell lines regardless of their TRAIL sensitivity. Inhibition of NF-KB via adenoviral expression of the IKB-A super-repressor only sensitized the TRAIL-resistant pancreatic cancer cell line Panc-1. Panc-1 cells harbor constitutively activated NF-KB, pointing to a possible role of preactivated NF-KB in protection from TRAIL. Furthermore, we could reduce X-linked inhibitor of apoptosis protein (XIAP) levels in Panc-1 cells by inhibition of constitutively activated NF-KB and sensitize Panc-1 cells to TRAIL by RNA interference against XIAP. These results implicate elevated XIAP levels caused by high basal NF-KB activity in TRAIL resistance and suggest that therapeutic strategies involving TRAIL can be abetted by inhibition of NF-KB and/or XIAP only in tumor cells with constitutively

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Regulation of apoptosis in the immune system

Cited by 303 publications

References 136 publications

Role of reactive oxygen species in the pathophysiology of human reproduction

Role of reactive oxygen species in the pathophysiology of human reproduction

The kiss of death: promises and failures of death receptors and ligands in cancer therapy

Constitutively Activated Nuclear Factor-κB, but not Induced NF-κB, Leads to TRAIL Resistance by Up-Regulation of X-Linked Inhibitor of Apoptosis Protein in Human Cancer Cells

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