Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin

Haridas, Parvathi; Soronen, Jarkko; Sädevirta, Sanja; Mysore, Raghavendra; Quagliarini, Fabiana; Pasternack, Arja; Metso, Jari; Perttilä, Julia; Leivonen, Marja; Smas, Cynthia M.; Fischer‐Posovszky, Pamela; Wabitsch, Martin; Ehnholm, Christian; Ritvos, Olli; Jauhiainen, Matti; Olkkonen, Vesa M.; Yki‐Järvinen, Hannele

doi:10.1210/jc.2015-1254

Cited by 78 publications

(69 citation statements)

References 37 publications

(48 reference statements)

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“…This would be fully consistent with its robust induction by insulin in WAT (Nidhina Haridas et al, 2015;Soronen et al, 2012). Under circumstances favouring FA deposition as TGs in WAT, it is plausible that hydrolysis of the stored TGs should simultaneously be suppressed.…”

Section: Discussionsupporting

confidence: 67%

“…Several studies have documented an induction of the Angptl8 message during adipocyte differentiation (Ebert et al, 2014;Ren et al, 2012) and by their treatment with insulin, which favours the storage of FAs as TGs (Ebert et al, 2014;Nidhina Haridas et al, 2015;Ren et al, 2012). In a previous study, Ren et al (2012) carried out transient siRNA-mediated knockdown of Angptl8 in the 3T3-L1 adipocyte model and observed a defect in their adipocytic differentiation.…”

Section: Discussionmentioning

confidence: 98%

“…Consistently, hepatic overexpression of Angptl8 resulted in elevated plasma triglycerides (TGs) in mice (Dang et al, 2016;Quagliarini et al, 2012;Wang et al, 2013). Angptl8 is markedly induced upon insulin stimulation in both hepatocytes and adipocytes (Nidhina Haridas et al, 2015;Ren et al, 2012). Overexpression of Angptl8 in hepatocytes was reported to enhance insulin signaling via the Akt-GSK3β and Akt-FoxO1 pathways (Rong Guo et al, 2016).…”

Section: Introductionmentioning

confidence: 94%

“…However, ANGPTL8 was found to be the the most strongly insulin-induced individual gene in human WAT in vivo (Nidhina Haridas et al, 2015;Soronen et al, 2012), suggesting that, apart from its function in the circulation, it may also execute an unknown intracellular function in adipocytes.…”

Section: Introductionmentioning

confidence: 99%

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Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition

Antharaparambat

Mysore

Liebisch³

et al. 2017

Atherosclerosis

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition

Antharaparambat

Mysore

Liebisch³

et al. 2017

Atherosclerosis

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“…The complex pathogenetic condition involves glucose and lipid metabolism, pancreatic function, and various adipocyte/ hepatocyte-derived cytokines (23), while betatrophin is identified as an adipokine/hepatokine related to the function of pancreatic islets and the regulation of lipid metabolism (5,9,10,24). Thus, we conducted a case control study to assess the hypothesis whether serum betatrophin relates to MetS.…”

Section: Discussionmentioning

confidence: 99%

Aumento del nivel de betatrofina en suero en sujetos con síndrome metabólico: estudio de casos y controles

Zhu¹,

Li²,

Dai³

et al. 2016

Nutr Hosp

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ResumenIntroducción: la betatrofina es una novedosa adipoquina que provoca la proliferación de células β pancreáticas e interviene en el metabolismo de los lípidos. Objetivos: el propósito de este estudio es evaluar el papel de la betatrofina en el síndrome metabólico. Método: se llevó a cabo un estudio hospitalario de casos y controles según sexo y edad. El nivel de betatrofina en suero fue evaluado mediante ensayo por inmunoabsorción ligado a enzimas. Se midieron las concentraciones en suero de 12 adipoquinas para evaluar las asociaciones con la betatrofina usando los kits comerciales Adipokine Magnetic Bead Panel. Los análisis estadísticos incluyeron correlación bivariada, análisis de curva ROC y análisis de regresión lineal multivariable. Resultados: el nivel de betatrofina en suero fue más elevado en pacientes con síndrome metabólico (997,36 ± 475,92 pg/ml, p = 0,001) que en los controles (735,35 ± 526,51 pg/ml). Frente al tercil más bajo, el tercil más alto del nivel de betatrofina mostró una asociación con mayor riesgo de síndrome metabólico (odds ratio ajustado = 3,521, intervalo de confianza [IC] 95% [1,413], p = 0,023). Se desarrolló la curva ROC de betatrofina para pronosticar la presencia de síndrome metabólico (área bajo la curva ROC = 0,682 [95% IC, 0,597-0,767], p < 0,001). Además, la betatrofina mostró correlación con distintos parámetros, como edad (r = 0,286, p < 0,001), índice de masa corporal (r = 0,160, p = 0,046), índice cintura-cadera (r = 0,241, p = 0,002), lipoproteína de alta densidad (r = -0,167, p = 0,037), lipoproteína de baja densidad (r = -0,195, p = 0,015), glucosa plasmática en ayunas (r = 0,266, p = 0,001), hemoglobina A1C (r = 0,314, p < 0,001), índice de resistencia a la insulina mediante HOMA (r = 0,272, p = 0,001) y diversas adipoquinas, entre ellas resistina (r = 0,571, p < 0,001), interleucina-8 (r = 0,435, p < 0,001), factor de necrosis tumoral alfa (r = 0,295, p = 0,011) y lipocalina-2 (r = 0,346, p = 0,003). Conclusiones: este estudio demuestra que la betatrofina en suero desempeña una importante labor en el síndrome metabólico, implicando la regulación del metabolismo de la glucosa y los lípidos y la inflamación. AbstractBackground: Betatrophin is a novel adipokine that provokes pancreatic β-cell proliferation and is involved in lipid metabolism. Aims: This study aims to evaluate the role of serum betatrophin in metabolic syndrome (MetS). Methods: A hospital-based, age-/gender-matched case control study was conducted. The serum betatrophin level was evaluated by enzymelinked immunosorbent assay. Serum concentrations of 12 adipokines were measured to assess their associations with serum betatrophin, using commercial Adipokine Magnetic Bead Panel kits. Statistical analyses included bivariate correlation, receiver operating characteristic (ROC) curve, and multivariate stepwise linear regression. Conclusions: This study supports that serum betatrophin plays an important role in MetS, involving the regulations of glucose and lipid metabolism and inflammation.

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Maternal and cord blood betatrophin (angiopoietin‐like protein 8) in pregnant women with gestational diabetes and normoglycemic controls: A systematic review, meta‐analysis, and meta‐regression

Pérez‐López

Yuan

Sánchez‐Prieto

et al. 2023

Diabetes Metabolism Res

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Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin

Abstract: Insulin decreases plasma ANGPTL3 by decreasing ANGPTL3 expression in the liver. Insulin markedly increases ANGPTL8 in adipose tissue and the liver but not in plasma. These data show that measurement of plasma ANGPTL3 but not -8 reflects insulin action in target tissues.

Cited by 78 publications

References 37 publications

Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition

Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition

Aumento del nivel de betatrofina en suero en sujetos con síndrome metabólico: estudio de casos y controles

Maternal and cord blood betatrophin (angiopoietin‐like protein 8) in pregnant women with gestational diabetes and normoglycemic controls: A systematic review, meta‐analysis, and meta‐regression

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