2015
DOI: 10.1016/j.neuropharm.2015.08.006
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Regulation of alternative gene transcription in the striatum in response to antidepressant drugs

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Cited by 8 publications
(18 citation statements)
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References 56 publications
(21 reference statements)
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“…2; lower panel). Consistent with the qPCR results, the previously published RNA-Seq studies by Piechota et al [24] showed higher levels of expression of Nr3c2 , Pgr and Esr1 in neurons and higher levels of expression of Nr3c1 in astrocytes. RNA-seq data published by Zhang et al [13] were similar to qPCR results with two differences—astrocytes exhibited higher levels of Nr3c2 , and mRNA of Esr1 was undetected.
Fig.
…”
Section: Resultssupporting
confidence: 90%
See 2 more Smart Citations
“…2; lower panel). Consistent with the qPCR results, the previously published RNA-Seq studies by Piechota et al [24] showed higher levels of expression of Nr3c2 , Pgr and Esr1 in neurons and higher levels of expression of Nr3c1 in astrocytes. RNA-seq data published by Zhang et al [13] were similar to qPCR results with two differences—astrocytes exhibited higher levels of Nr3c2 , and mRNA of Esr1 was undetected.
Fig.
…”
Section: Resultssupporting
confidence: 90%
“…Astrocytes showed higher levels of abundance of glucocorticoid receptor ( Nr3c1 ) ( p  = 7.4 × 10 −7 ). In addition, to compare mRNA levels between the receptors we used the available RNA-seq data from previous experiments by Piechota et al [24] (Fig. 2; middle panel) and by Zhang et al [13] (Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…All animals were decapitated 2 h after treatment, and brains were then extracted and dissected with needles under a binocular. Drug doses that produce robust and comparable gene expression alterations were selected based on our previous experience [ 2 , 3 , 13 ]. Doses were selected to provide a reasonable comparison of the effects of each drug on the molecular level.…”
Section: Methodsmentioning
confidence: 99%
“…Treatment with psychotropic drugs aims to restore the normal function of the affected circuits; long-term therapeutic benefits may depend on the ability of drugs to restore normal plasticity. Consistent with this notion, commonly used psychotropic drugs robustly induce molecular effects on the brain associated with neuroplastic alterations [ 2 , 3 ].…”
Section: Introductionmentioning
confidence: 93%