Regulation of adipokine production in human adipose tissue by propionic acid

Al-Lahham, Saad; Roelofsen, Han; Priebe, Marion; Weening, Desireé; Dijkstra, Martijn; Hoek, Annemieke; Rezaee, Farhad; Venema, Koen; Vonk, Roel J.

doi:10.1111/j.1365-2362.2010.02278.x

Cited by 190 publications

(161 citation statements)

References 40 publications

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“…In 2004, Xiong et al [147] reported increased plasma leptin levels in mice following acute oral administration of sodium propionate. Enhanced expression of this anorexigenic hormone in human adipose tissue was also reported by Al-Lahham et al [148] in 2010. Both studies suggest an involvement of GPR41 in this process.…”

Section: Propionic Acidsupporting

confidence: 70%

“…Hence, the impact of PA on infl ammation could be linked to particular effects on obesity. Al-Lahham et al [148] observed that incubation of human adipose tissue with PA reduces the expression of resistin which is a pro-infl ammatory factor, the action of which is probably mediated by GPR43 on macrophages. Moreover, PA was reported to inhibit activated human lymphocyte proliferation in a concentrationdependent manner [158].…”

Section: Propionic Acidmentioning

confidence: 99%

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Reevaluating the hype: four bacterial metabolites under scrutiny

Fröhlich

Mayerhofer

Holzer

2015

European Journal of Microbiology and Immunology

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With microbiome research being a fiercely contested playground in science, new data are being published at tremendous pace. The review at hand serves to critically revise four microbial metabolites widely applied in research: butyric acid, flagellin, lipoteichoic acid, and propionic acid. All four metabolites are physiologically present in healthy humans. Nevertheless, all four are likewise involved in pathologies ranging from cancer to mental retardation. Their inflammatory potential is equally friend and foe. The authors systematically analyze positive and negative attributes of the aforementioned substances, indicating chances and dangers with the use of pre-and probiotic therapeutics. Furthermore, the widespread actions of microbial metabolites on distinct organs and diseases are reconciled. Moreover, the review serves as critical discourse on scientific methods commonly employed in microbiome research and comparability as well as reproducibility issues arising thereof.

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Section: Propionic Acidsupporting

confidence: 70%

Section: Propionic Acidmentioning

confidence: 99%

Reevaluating the hype: four bacterial metabolites under scrutiny

Fröhlich

Mayerhofer

Holzer

2015

European Journal of Microbiology and Immunology

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“…However, shortchain fatty acids have been found to improve glycemic control, modulate nutrient trafficking and oxidation, modulate the expression level of several proteins/enzymes, that regulate energy balance including leptin, and may positively affect body weight control [54,66,67]. Given the involvement of leptin and adiponectin in glucose and energy metabolism, the negative association between butyric acid consumption and leptin/adiponectin ratio that has been detected in the current study, may reflect the beneficial metabolic effect of butyric acid.…”

Section: Discussionmentioning

confidence: 52%

“…One dietary fiber-derivative, propionic acid, was found to inhibit the expression level of resistin, a component of inflammation and insulin resistance [54]. The consumption of a healthy dietary pattern was associated with a significant reduction in resistin level in a large sample of apparently healthy women and the researchers suggested that the effect was mediated, partly, by cereal fiber consumption [35].…”

Section: Discussionmentioning

confidence: 99%

Exploration of micro- and macronutrient consumption and leverage of interaction with adipokines among Jordanian adults

Tayyem¹,

Hijjawi²,

Bawadi³

et al. 2017

clinical-practice

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Methods and Results:A convenient sample of 167 adults was obtained from students and employees in major hospital in Jordan. Serum concentrations of leptin, adiponectin, resistin and interleukine-6 were measured. Nutrients intakes were assessed using a validated quantitative food frequency questionnaire. Higher levels of leptin were associated with the highest consumption of energy from carbohydrate, insoluble, and soluble fiber (P=0.04). Lower levels of leptin were associated with highest consumption of energy from fat (P=0.04), monounsaturated fatty acids (P=0.04) and cholesterol (P=0.02). Lower levels of adiponectin were found among individuals with the highest consumption of carbohydrates (p=0.02) insoluble fibers (P=0.01); and copper (P=0.03). Higher levels of adiponectin were associated with higher consumption of cholesterol (P=0.03). Leptin/adiponectin ratio was positively associated with the intakes of carbohydrates (P=0.04), soluble-(P=0.01) and insoluble fibers (P=0.01) and copper (P=0.03), whereas the ratio was negatively associated with cholesterol (P=0.04), butyric acid (P=0.03) and omega-3 fatty acids (P=0.03). Levels of resistin were only associated with total fiber intake (P=0.04) and levels of interleukine-6 were only associated with cholesterol intake (P=0.01). Conclusion:Our findings suggest that intakes of carbohydrates, fat, cholesterol and fibers are the major dietary factors that may be associated with levels of leptin and adiponectin. Levels of resistin and interleukine-6 may be less associated with diet composition.

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“…Interestingly, SCFA and BA receptors (i.e. GPR43 and FXR) are expressed in adipose tissue, and both SCFA and BA have been able to modulate fasting and β-adrenoceptor-mediated lipolysis in murine and human adipocytes [15,26]. indicating a possible role for BA and SCFA signaling in catecholamine-induced lipolysis.…”

Section: Discussionmentioning

confidence: 99%

Effects of gut microbiota manipulation onex vivolipolysis in human abdominal subcutaneous adipocytes

Jocken¹,

Reijnders

Canfora³

et al. 2018

Adipocyte

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The intestinal microbiota may contribute to the development of obesity by affecting host lipid metabolism and insulin sensitivity. To investigate the effects of microbiota manipulation on ex vivo basal and β-adrenergically-stimulated lipolysis in human adipocytes, 36 obese men were randomized to amoxicillin (broad-spectrum antibiotic), vancomycin (narrow-spectrum antibiotic) or placebo treatment (7 d, 1500 mg/d). Before and after treatment, ex vivo adipose tissue lipolysis was assessed under basal conditions and during stimulation with the non-selective β-agonist isoprenaline using freshly isolated mature adipocytes. Gene (targeted microarray) and protein expression were analyzed to investigate underlying pathways.Antibiotics treatment did not significantly affect basal and maximal isoprenaline-mediated glycerol release from adipocytes. Adipose tissue β-adrenoceptor expression or post-receptor signalling was also not different between groups. In conclusion, 7 d oral antibiotics treatment has no effect on ex vivo lipolysis in mature adipocytes derived from adipose tissue of obese insulin resistant men.

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Regulation of adipokine production in human adipose tissue by propionic acid

Cited by 190 publications

References 40 publications

Reevaluating the hype: four bacterial metabolites under scrutiny

Reevaluating the hype: four bacterial metabolites under scrutiny

Exploration of micro- and macronutrient consumption and leverage of interaction with adipokines among Jordanian adults

Effects of gut microbiota manipulation onex vivolipolysis in human abdominal subcutaneous adipocytes

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