Regulation of adipogenesis by exosomal milk miRNA

Abbas, Manal A.; Al-Saigh, Noor Nadhim; Saqallah, Fadi G.

doi:10.1007/s11154-023-09788-3

Cited by 17 publications

(11 citation statements)

References 143 publications

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“…Transfection with the milk-derived miR-22 promoted cell proliferation by inhibition of CCAAT/enhancer-binding protein δ (C/EBPδ) expression and promotion of intestinal development in human intestinal epithelial cells [ 42 ]. On the other hand, the milk-exosomal miR-148a and miR-30b have been correlated to adipogenic effects, supporting a correlation between milk consumption and obesity incidence [ 43 ]. In vitro and in vivo studies reported that milk exosome-derived miRNAs also exert oncogenic or oncosuppressor properties ( Figure 2 ).…”

Section: Dietary Xenomirnas In Health and Diseasementioning

confidence: 99%

“…In addition, the biological and functional role of dietary miRNAs from different sources in human health is still controversial. Different milk-derived miRNAs have been reported to modulate oncogenic and adipogenic pathways, promoting the development of B-cell lymphoma, hormone-dependent breast and prostate cancer [ 43 , 44 , 45 , 47 ], as well as the ginger-related miRNA has been associated with colitis development [ 64 ] and the pork-derived miRNAs to the development of metabolic disorders in mice [ 22 ]. The evaluation of food-derived xenomiRNA effects cannot refrain from considering the co-existence of a great variety of dietary bioactive compounds.…”

Section: Questions Opening On the Potential Impact Of Dietary Mirnas ...mentioning

confidence: 99%

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Dietary Epigenetic Modulators: Unravelling the Still-Controversial Benefits of miRNAs in Nutrition and Disease

Martino,

D’Onofrio,

Balestrieri

et al. 2024

Nutrients

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In the context of nutrient-driven epigenetic alterations, food-derived miRNAs can be absorbed into the circulatory system and organs of recipients, especially humans, and potentially contribute to modulating health and diseases. Evidence suggests that food uptake, by carrying exogenous miRNAs (xenomiRNAs), regulates the individual miRNA profile, modifying the redox homeostasis and inflammatory conditions underlying pathological processes, such as type 2 diabetes mellitus, insulin resistance, metabolic syndrome, and cancer. The capacity of diet to control miRNA levels and the comprehension of the unique characteristics of dietary miRNAs in terms of gene expression regulation show important perspectives as a strategy to control disease susceptibility via epigenetic modifications and refine the clinical outcomes. However, the absorption, stability, availability, and epigenetic roles of dietary miRNAs are intriguing and currently the subject of intense debate; additionally, there is restricted knowledge of their physiological and potential side effects. Within this framework, we provided up-to-date and comprehensive knowledge on dietary miRNAs’ potential, discussing the latest advances and controversial issues related to the role of miRNAs in human health and disease as modulators of chronic syndromes.

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Section: Dietary Xenomirnas In Health and Diseasementioning

confidence: 99%

Section: Questions Opening On the Potential Impact Of Dietary Mirnas ...mentioning

confidence: 99%

Dietary Epigenetic Modulators: Unravelling the Still-Controversial Benefits of miRNAs in Nutrition and Disease

Martino,

D’Onofrio,

Balestrieri

et al. 2024

Nutrients

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“…Thus, miRNAs supplied by breast milk can allow effective molecular communication between the mother and the infant [151,152], participating in signaling and regulatory mechanisms during the early postnatal period and maybe contributing to metabolic programming. For example, many studies have linked the presence of specific miRNAs in milk to the regulation of immune responses [152][153][154], epigenetic mechanisms [155][156][157], metabolism [153], and also adipogenesis [158].…”

Section: Mirnas In Milkmentioning

confidence: 99%

Early Life Programming of Adipose Tissue Remodeling and Browning Capacity by Micronutrients and Bioactive Compounds as a Potential Anti-Obesity Strategy

Bonet,

Ribot,

Sánchez

et al. 2024

Cells

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The early stages of life, especially the period from conception to two years, are crucial for shaping metabolic health and the risk of obesity in adulthood. Adipose tissue (AT) plays a crucial role in regulating energy homeostasis and metabolism, and brown AT (BAT) and the browning of white AT (WAT) are promising targets for combating weight gain. Nutritional factors during prenatal and early postnatal stages can influence the development of AT, affecting the likelihood of obesity later on. This narrative review focuses on the nutritional programming of AT features. Research conducted across various animal models with diverse interventions has provided insights into the effects of specific compounds on AT development and function, influencing the development of crucial structures and neuroendocrine circuits responsible for energy balance. The hormone leptin has been identified as an essential nutrient during lactation for healthy metabolic programming against obesity development in adults. Studies have also highlighted that maternal supplementation with polyunsaturated fatty acids (PUFAs), vitamin A, nicotinamide riboside, and polyphenols during pregnancy and lactation, as well as offspring supplementation with myo-inositol, vitamin A, nicotinamide riboside, and resveratrol during the suckling period, can impact AT features and long-term health outcomes and help understand predisposition to obesity later in life.

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“…Human milk exosomes also contain various miRNAs associated with adipogenesis, the process of fat cell development, while concerns have arisen regarding the potential transfer of adipogenic miRNAs across species through milk consumption, particularly as humans consume milk from other animals throughout their lives ( Abbas et al ., 2023 ). However, evidence linking dairy milk consumption to increased obesity rates remains inconclusive.…”

Section: Exosomes In Breast Milkmentioning

confidence: 99%

Fingerprinting Breast Milk; insights into Milk Exosomics

Papakonstantinou,

Dragoumani,

Mataragka

et al. 2024

EMBnet j.

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Breast milk, often referred to as "liquid gold," is a complex biofluid that provides essential nutrients, immune factors, and developmental cues for newborns. Recent advancements in the field of exosome research have shed light on the critical role of exosomes in breast milk. Exosomes are nanosized vesicles that carry bioactive molecules, including proteins, lipids, nucleic acids, and miRNAs. These tiny messengers play a vital role in intercellular communication and are now being recognized as key players in infant health and development. This paper explores the emerging field of milk exosomics, emphasizing the potential of exosome fingerprinting to uncover valuable insights into the composition and function of breast milk. By deciphering the exosomal cargo, we can gain a deeper understanding of how breast milk influences neonatal health and may even pave the way for personalized nutrition strategies.

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Regulation of adipogenesis by exosomal milk miRNA

Cited by 17 publications

References 143 publications

Dietary Epigenetic Modulators: Unravelling the Still-Controversial Benefits of miRNAs in Nutrition and Disease

Dietary Epigenetic Modulators: Unravelling the Still-Controversial Benefits of miRNAs in Nutrition and Disease

Early Life Programming of Adipose Tissue Remodeling and Browning Capacity by Micronutrients and Bioactive Compounds as a Potential Anti-Obesity Strategy

Fingerprinting Breast Milk; insights into Milk Exosomics

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