Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin

Citrus flavonoids and lipid metabolism

“…Intracellular lipid accumulation was significantly attenuated in 3T3L1 adipocytes treated with 64 mM nobiletin, whereas there was no effect with the same dose of tangeretin [45]. Nevertheless, monocyte chemotactic protein-1 (MCP-1) secretion into the media was significantly attenuated following treatment of these cells with 128 mM tangeretin or nobiletin [45].…”

“…In cultured cells, lipoplysaccharide (LPS)-stimulated RAW 264.7 macrophages treated with 10-40 mg/ml 7-O-methylnaringenin dose-dependently down-regulated TNFa, IL-1b and IL-6 expression while preventing LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK) and inhibitor of kappa B alpha (IkBa) [44]. Intracellular lipid accumulation was significantly attenuated in 3T3L1 adipocytes treated with 64 mM nobiletin, whereas there was no effect with the same dose of tangeretin [45]. Nevertheless, monocyte chemotactic protein-1 (MCP-1) secretion into the media was significantly attenuated following treatment of these cells with 128 mM tangeretin or nobiletin [45].…”

In Vivo and In Vitro Protective Effects of Pentamethylquercetin on Cardiac Hypertrophy

“…Positive regulation of adiponectin expression and secretion in vitro has also been reported [12,13]. Furthermore, besides effects on the adipogenesis of 3T3-L1 cells [14] and an increase in ocular blood flow [15], accumulating evidence has demonstrated that pentamethylquercetin (PMQ), a member of PMFs found specifically in seabuckthom [16], could reduce cardiac hypertrophy and apoptosis induced by angiotensinII [17].…”

Six New Chalcones fromAngelica keiskeiInducing Adiponectin Production in 3T3-L1 Adipocytes

“…Recent studies have shown that several phytochemicals enhanced adiponectin production in adipocytes. [20][21][22][23][24] The objective of this study was to isolate new chalcones from A. keiskei and to evaluate their potential for producing adiponectin in 3T3-L1 adipocytes.…”