Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial

Kadooka, Yukio; Sato, Masao; Imaizumi, Kazunori; Ogawa, Aiko; Ikuyama, Ken; Akai, Yasuhiro; Okano, Mariko; Kagoshima, Masatoyo; Tsuchida, Takashi

doi:10.1038/ejcn.2010.19

Cited by 589 publications

(407 citation statements)

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“…Reductions of blood glucose and body weight have been observed in type 2 diabetic mice in association with a reduction of food intake (Yun et al, 2009). Administration of L. gasseri in fermented milk for 12 weeks reduces adiposity and body weight in obese adults, possibly by reducing lipid absorption and inflammatory status (Kadooka et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Short-term modifications in the distal gut microbiota of weaning mice induced by a high-fat diet

et al. 2012

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The gut microbiota has been shown to be involved in host energy homeostasis and diet-induced metabolic disorders. To gain insight into the relationships among diet, microbiota and the host, we evaluated the effects of a high-fat (HF) diet on the gut bacterial community in weaning mice. C57BL/6 mice were fed either a control diet or a diet enriched with soy oil for 1 and 2 weeks. Administration of the HF diet caused an increase in plasma total cholesterol levels, while no significant differences in body weight gain were observed between the two diets. Denaturing gradient gel electrophoresis (DGGE) profiles indicated considerable variations in the caecal microbial communities of mice on the HF diet, as compared with controls. Two DGGE bands with reduced intensities in HF-fed mice were identified as representing Lactobacillus gasseri and an uncultured Bacteroides species, whereas a band of increased intensity was identified as representing a Clostridium populeti-related species upon sequencing. Quantitative real-time PCR confirmed a statistically significant 1-log decrease in L. gasseri cell numbers after HF feeding, and revealed a significantly lower level of Bifidobacterium spp. in the control groups after 1 and 2 weeks compared with that in the HF groups. These alterations of intestinal microbiota were not associated with caecum inflammation, as assessed by histological analysis. The observed shifts of specific bacterial populations within the gut may represent an early consequence of increased dietary fat.

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Section: Discussionmentioning

confidence: 99%

Short-term modifications in the distal gut microbiota of weaning mice induced by a high-fat diet

et al. 2012

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“…Studies of L. gasseri in humans have shown decreases in abdominal adiposity, body weight, and waist and hip circumferences after oral use of probiotics (Kadooka et al, 2010;Jung et al, 2013). Several studies show that the use of this microorganism in rats decreased visceral fat by enhancing lipid excretion (Yonejima, Ushida, Mori, 2013), reduced adipocyte size (Sato et al, 2008;Hamad et al, 2009), and reduced body weight (Kang Yun, Park, 2010;Kang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Changes in weight and body fat after use of tetracycline and Lactobacillus gasseri in rats

Marciano

Fiol²,

Ferreira

et al. 2017

Braz. J. Pharm. Sci.

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Recent studies have shown a role of intestinal microbiota in obesity. The consumption of antibiotics in the last 70 years has led to changes in intestinal microbiota, which has led to weight gain and body fat accumulation. To evaluate the possibility of weight gain induced by antibiotics and the possible protective effect of probiotics, we divided 45 animals (Rattus norvegicus) into groups and administered the following treatments over two weeks: tetracycline, tetracycline + Lactobacillus gasseri, and NaCl. The animals were weighed over the course of 8 weeks, and at the end of the treatment period, they were measured and subjected to bioelectrical impedance analysis. The results show that the group receiving tetracycline alone had a higher body mass index (p=0.030), a greater Lee index (p=0.008), and a lower body water percentage than the control group, indicating a greater accumulation of body fat. The group receiving the probiotics with tetracycline presented similar results to the control group, indicating a possible protective effect of body fat accumulation in the group receiving tetracycline alone. The results show that tetracycline increased the concentration of body fat, and the use of probiotics was associated with an ability to protect the animals from the pro-obesity effect.

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“…For instance, L. rhamnosus GG (ATCC 53103) and Bifidobacterium lactis Bb12 along with dietary counseling were found to influence maternal anthropometric measurements during and after pregnancy (Ilmonen et al 2011). The reduction in these measurements was also observed in overweight adults after 12 weeks of intervention with L. gasseri SBT2055 (Kadooka et al 2010). In addition, the perinatal use of L. rhamnosus GG was demonstrated to inhibit excessive weight gain in children during the first years of life (Luoto et al 2010).…”

Section: Probioticsmentioning

confidence: 99%

The art of targeting gut microbiota for tackling human obesity

Aguirre

Venema

2015

Genes Nutr

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Recently, a great deal of interest has been expressed regarding strategies to tackle worldwide obesity because of its accelerated wide spread accompanied with numerous negative effects on health and high costs. Obesity has been traditionally associated with an imbalance in energy consumed when compared to energy expenditure. However, growing evidence suggests a less simplistic event in which gut microbiota plays a key role. Obesity, in terms of microbiota, is a complicated disequilibrium that presents many unclear complications. Despite this, there is special interest in characterizing compositionally and functionally the obese gut microbiota with the help of in vitro, animal and human studies. Considering the gut microbiota as a factor contributing to human obesity represents a tool of great therapeutic potential. This paper reviews the use of antimicrobials, probiotics, fecal microbial therapy, prebiotics and diet to manipulate obesity through the human gut microbiota and reveals inconsistencies and implications for future study.

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Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial

Abstract: The probiotic LG2055 showed lowering effects on abdominal adiposity, body weight and other measures, suggesting its beneficial influence on metabolic disorders.

Cited by 589 publications

References 38 publications

Short-term modifications in the distal gut microbiota of weaning mice induced by a high-fat diet

Short-term modifications in the distal gut microbiota of weaning mice induced by a high-fat diet

Changes in weight and body fat after use of tetracycline and Lactobacillus gasseri in rats

The art of targeting gut microbiota for tackling human obesity

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