Regulation Effects of Crataegus pinnatifida Leaf on Glucose and Lipids Metabolism

Abstract

The leaf of Crataegus pinnatifida (Rosaceae) is commonly consumed either raw or cooked to improve digestion and promote blood circulation in China. To investigate the regulation effects of it on glucose and lipid metabolism, the flavonoids fraction was prepared and analyzed by HPLC and LC-MS. In vivo, at doses of 250 and 500 mg/kg, the flavonoids fraction showed inhibitory effects on TG and glucose absorption, accelerating effects on gastrointestinal transit but no effect on gastric emptying. In vitro, treatment of 3T3-L1 preadipocytes with 30 μg/mL flavonoids fraction significantly suppressed the accumulation of TG and free fatty acid. It also suppressed the gene expressions of C/EBPα, PPARγ, SREBP 1c, aP2 and adiponectin but did not affect that of leptin. C. pinnatifida leaf may be useful for type 2 diabetics and hyperlipidemics as a foodstuff.

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

“…The flavonoids fraction showed inhibitory effects on TG and glucose absorption and accelerating effects on gastrointestinal transit in vivo and suppressed the accumulation of TG and free fatty acid. It also suppressed the gene expressions of C/EBP α , PPAR γ , SREBP 1c, aP2, and adiponectin in vitro [79]. As we know, LPL plays an important role in lipoprotein metabolism and is expressed in various tissues, especially adipose and muscle tissue, where it plays different roles.…”

Hawthorn Fruit Attenuates Atherosclerosis by Improving the Hypolipidemic and Antioxidant Activities in Apolipoprotein E-Deficient Mice

“…Moreover, the chemical composition of hawthorn fruit has been the subject of extensive studies 7) . Flavonoids and proanthocyanidins, major ingredients of hawthorn fruit, are responsible for the fruit's pharmacological activity 8) . Nevertheless, the effects of hawthorn fruit in preventing cardiovascular diseases remain unknown.…”

Changes in physicochemical characteristics and free amino acids of hawthorn (Crataegus pinnatifida) fruits during maturation

“…It is also an important component of many processed food products because of its excellent flavour, attractive colour and high content of many macro-and micro-nutrients (Cao, Feng, & Qin, 1995;Özcan, Hacıseferoğulları, Marakoğlu, & Arslan, 2005). In China, the hawthorn species is widely cultivated for its edible fruits (Cui et al, 2006), and have recently attracted increasing attention in the field of nutraceuticals and medicine because their leaves, flowers, and both green (unripe) and red (ripe) berries are widely reported health benefits besides rich nutrient contents (Wang et al, 2011;Kirakosyan et al, 2003), e.g., the reduction of the risk of cardiovascular diseases (Pittler, Schmidt, & Ernst, 2003;Chang, Dao, & Shao, 2005) and offering antioxidant, of utilization and development are discarded during the ripening of fruits every year, which no doubt cause enormous waste of resources. The reason for this lies in lacking the effective evaluation on physicochemical properties, nutritional value of unripe fruits.…”