Regulation der mikrobiellen Alkanoxidation mit Hinblick auf die Produktbildung

Rehm, Hans‐Jürgen; Reiff, I.

doi:10.1002/abio.370020203

Cited by 8 publications

(4 citation statements)

References 33 publications

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“…For example, Rehm & Reiff (1982) investigated the initial mode of attack on C8 to C18 n-alkanes by a variety of bacteria and fungi. Most organisms brought about terminal oxidation only but with certain Aspergillus, Fusarium and Bacillus spp.…”

Section: Metabolism Of N-alkanesmentioning

confidence: 99%

“…Woods & Murrell (1989) have reported that the propane-oxidising bacterium Rhodococcus rhodochrous can produce monoterminal and diterminal oxidation of C2-Cs n-alkanes via a system that is not linked to cytochrome P-450. In a survey of n-alkane oxidation in a number of microbial species, Rehm & Reiff (1982) observed diterminal oxidation products only rarely. All of these products may be further metabolized by means of the []-oxidation pathway for fatty acids.…”

Section: Metabolism Of N-alkanesmentioning

confidence: 99%

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Physiology of aliphatic hydrocarbon-degrading microorganisms

1990

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This paper reviews aspects of the physiology and biochemistry of the microbial biodegradation of alkanes larger than methane, alkenes and alkynes with particular emphasis upon recent developments. Subject areas discussed include: substrate uptake; metabolic pathways for alkenes and straight and branched-chain alkanes; the genetics and regulation of pathways; co-oxidation of aliphatic hydrocarbons; the potential for anaerobic aliphatic hydrocarbon degradation; the potential deployment of aliphatic hydrocarbon-degrading microorganisms in biotechnology.

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Section: Metabolism Of N-alkanesmentioning

confidence: 99%

Section: Metabolism Of N-alkanesmentioning

confidence: 99%

Physiology of aliphatic hydrocarbon-degrading microorganisms

1990

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“…Alkanes and fatty acids are oxidized via subterminal, terminal or diterminal oxidation [17][18][19][20][21]. Subterminal oxidation is described for Aspergillus sp., Fusarium spp.…”

Section: Oxidation Mechanismsmentioning

confidence: 99%

“…and Bacillus spp. and represents the oxidation of subterminal carbon atoms in the alkanes or fatty acids [19]. Terminal and diterminal oxidation is described in different yeast species e.g., Candida tropicalis, C. maltosa and Yarrowia lipolytica and represents the oxidation of terminal methyl groups of alkanes or fatty acids [21,22].…”

Section: Oxidation Mechanismsmentioning

confidence: 99%

Biotechnological synthesis of long‐chain dicarboxylic acids as building blocks for polymers

Huf

Krügener

Hirth

et al. 2011

Eur. J. Lipid Sci. Technol.

119

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An important field in sustainable industrial chemistry is the development of new applications for fats and oils. One of the promising applications is the use of fatty acid derivatives, e.g. dicarboxylic acid (DCA), as polymer building blocks. In contrast to conventional plastics, bioplastics are polymers derived from renewable biomass sources. In addition to their contribution to the conservation of fossil resources and reduction in CO2 emissions by waste incineration, many bioplastics are biodegradable. The majority of industrial DCA production for polyamide (PA) and polyester (PE) synthesis is still done via chemical synthesis. While short-chain DCA can be synthesized in high yields, costs of long-chain DCA production rise significantly due to the generation of various by-products and are connected mostly to a costly purification. Thus biotechnology provides novel biochemical approaches for long-chain DCA synthesis that can provide an eco-efficient process alternative . In the present article, strategies for the development of high-level production strains for long-chain DCA are illustrated. Basic strategies for strain development, in order to achieve an effective enrichment of DCA, require the knowledge of the respective biochemical pathways. These are discussed in detail. Furthermore an overview of fermentation strategies and characteristics of corresponding polymers is given

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Regulation der fettsäurebildung bei der mikrobiellen alkanoxidation

Rehm

Hortmann

Reiff

1983

Acta Biotechnologica

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TibusstraBe 7 -15, D -4400 Miinster Biotechnologie-Symposium 1982, Leipzig, DDR SummaryAt the microbial oxidation of long-chain alkanes such monocarbonic acids a t a monoterminal oxidation are formed which correspond to the chain length of the alkanes. At diterminal oxidation the corresponding dioic acids are produced. Under the influence of cerulenin a direct incorporation of fatty acids into cell lipids increases. Undecanoic acid cannot be metabolized by Mwtierella isabellina. It causes an inhibition of alkane oxidation. A main effect of undecanoic acid is an inhibition of the elongation of other fatty acids.The de novo fatty acid biosynthesis has not been inhibited by iindecunoic acid. ZusammenftbssungBei der mikrobiellen Oxidation liingerkettiger Alkane entstehen bei einer terminalen Oxidation die der Kettenliinge entsprechenden Monocarbonsauren, bei einer dibrminalen Oxidation werden entsprechende Dicarbonsiiuren gebildet. U n b r dem EinfluB von Cerulenin erhoht sich der direkte Einbau der Fettsauren in die Zellipide. Undekansiiure (Hendecylsiiure) wird von Mortierella isabellina nicht als Fettsiiure aufgenommen, sondern ruft eine Hemmung der Alkanoxidation hervor. Eine wesentliche Wirkung der Undekansiiure liegt in einer Hemmung der Elongation anderer gebildeter Fettsiiuren. Die de novo-Fettsiiurebiosynthese wird durch UndekansLiure nicht gehemmt. Einleitung Uber die Regulation der mikrobiellen A3kanoxidation gibt es eine Reihe von Ergebnissen: REEM und REIFF [lo, 111; KLEBEB und SATTLEE [S]. Dagegen ist die Regulation der Bildung von aus der Alkanoxidation entstandenen Folgeprodukten, besonders der als erste wichtige Substanzen entatandenen Fettsiiuren, weniger untersucht worden, obwohl es eine ganze Anzahl von Arbeiten gibt, in denen die aus Alkanen gebildeten extrazellularen und intrazelluliiren Fettsiiuren identifiziert worden sind. I m folgenden sollen einige wichtige Mechanismen der Regulation der Fettsaurebildung dargestellt werden und zwar 1. die Regulation in Abhangigkeit von Oxidationsmechanismen 2. Kinetiken der Fettsiiurebildung monoterminal oxidierender Mikroorganismen 3. Wirkung von Cerulenin auf die Fettsaurebildung von Mortierella isabellina 4. besondere Regulation durch eine C,,-Siiure.

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Regulation der mikrobiellen Alkanoxidation mit Hinblick auf die Produktbildung

Cited by 8 publications

References 33 publications

Physiology of aliphatic hydrocarbon-degrading microorganisms

Physiology of aliphatic hydrocarbon-degrading microorganisms

Biotechnological synthesis of long‐chain dicarboxylic acids as building blocks for polymers

Regulation der fettsäurebildung bei der mikrobiellen alkanoxidation

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