Regulation and physiological functions of phoenixin

Liu, Han; Zhao, Qian; Lv, Shuangyu; Ji, Xin‐Ying

doi:10.3389/fmolb.2022.956500

Cited by 15 publications

(14 citation statements)

References 79 publications

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“…Expression of PNX and its receptor GPR173 in the arcuate nucleus and paraventricular nucleus, which are closely related to the regulation of food intake in the brain, led scientists to speculate that PNX may have a potential role in regulating food intake 9 . Subsequently, animal model studies began to be reported on the effect of PNX on food intake.…”

Section: Discussionmentioning

confidence: 99%

“…Although there are many PNX isoforms with different amino acid lengths, all formed by cleavage from the same precursor peptide; PNX-14 and PNX-20 are the most predominantly expressed isoforms [7,11] Therefore, most of the studies related to PNX in the literature have been done on PNX-14 and PNX-20 isoforms. Expression of PNX and its receptor GPR173 in the arcuate nucleus and paraventricular nucleus, which are closely related to the regulation of food intake in the brain, led scientists to speculate that PNX may have a potential role in regulating food intake [9]. Subsequently, animal model studies began to be reported on the effect of PNX on food intake.…”

Section: Median (Iqr) Mean ± Sd Median (Iqr) Mean ± Sd P-valuementioning

confidence: 99%

“…Subsequent studies have shown that in addition to the hypothalamus, PNX is also expressed in the spinal cord, heart, thymus, esophagus, stomach, small and large intestines, pancreas, ovaries, skin, and adipose tissue in rats [8]. Thus, PNX is thought to play a role in behavior, memory, sensory processes, glucose and lipid metabolism, fluid homeostasis, and food intake, as well as promoting the secretion of gonadotropins and steroid hormones [9].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Serum Phoenixin-14 Concentration in Pregnant Women Diagnosed with Hyperemesis Gravidarum

Çimenli

Kale

Muhçu

2023

Z Geburtshilfe Neonatol

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Objective We aimed to investigate the relationship between the hyperemesis gravidarum (HG) and maternal serum phoenixin-14 (PNX-14) concentrations. Materials and methods This cross-sectional study was conducted with 88 pregnant women who applied to the Umraniye Training and Research Hospital Gynecology and Obstetrics Clinic between February 2022 and October 2022. The HG group consisted of 44 pregnant women diagnosed with HG between the 7th and 14th gestational weeks, and the control group consisted of 44 healthy pregnant women matched with the HG group in terms of age, BMI, and gestational week. Demographic characteristics, ultrasound findings, and laboratory outcomes were noted. The two groups were compared in terms of maternal serum PNX-14 concentrations. Results Gestational age at blood sampling for PNX-14 was similar in both groups (p=1.000). While maternal serum PNX-14 concentration was 85.5 pg/ml in the HG group, it was 71.3 pg/ml in the control group (p=0.012). ROC analysis was performed to determine the value of maternal serum PNX-14 concentration in terms of predicting HG. AUC analysis of maternal serum PNX-14 for HG estimation was 0.656 (p=0.012, 95% CI=0.54–0.77). The optimal cutoff value for maternal serum PNX-14 concentration was determined as 79.81 pg/ml with 59% sensitivity and 59% specificity. Conclusion In this study, maternal serum PNX-14 concentration was found to be higher in pregnant women with HG, which indicates that high serum PNX-14 concentrations may have an anorexigenic effect on food intake in pregnancy. Concentrations of other PNX isoforms in HG and changes in PNX concentrations in pregnant women with HG who regained weight after treatment remain to be investigated.

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Section: Discussionmentioning

confidence: 99%

Section: Median (Iqr) Mean ± Sd Median (Iqr) Mean ± Sd P-valuementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigation of Serum Phoenixin-14 Concentration in Pregnant Women Diagnosed with Hyperemesis Gravidarum

Çimenli

Kale

Muhçu

2023

Z Geburtshilfe Neonatol

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“…By inducing the expression of gonadotropin-releasing hormone receptor and increasing gonadotropin-releasing hormone, PNX stimulates luteinizing hormone (LH) release in pituitary cells of female mice [ 9 ]. Two active forms of PNX were discovered in mice, including PNX-14 and PHN-20 [ 10 ]. Chi [ 11 ] claimed that PHN-20 alleviated the pathological symptoms of gestational diabetes mellitus by repressing OS and inflammation.…”

Section: Introductionmentioning

confidence: 99%

Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress

Chai,

Gu,

Zhang

et al. 2024

Aging

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Pulmonary arterial hypertension (PAH) is a severe pathophysiological syndrome resulting in heart failure, which is found to be induced by pulmonary vascular remodeling mediated by oxidative stress (OS) and inflammation. Phoenixin-20 (PNX-20) is a reproductive peptide first discovered in mice with potential suppressive properties against OS and inflammatory response. Our study will explore the possible therapeutic functions of PHN-20 against PAH for future clinical application. Rats were treated with normal saline, PHN-20 (100 ng/g body weight daily), hypoxia, hypoxia+PHN-20 (100 ng/g body weight daily), respectively. A signally elevated RVSP, mPAP, RV/LV + S, and W%, increased secretion of cytokines, enhanced malondialdehyde (MDA) level, repressed superoxide dismutase (SOD) activity, and activated NLRP3 signaling were observed in hypoxia-stimulated rats, which were notably reversed by PHN-20 administration. Pulmonary microvascular endothelial cells (PMECs) were treated with hypoxia with or without PHN-20 (10 and 20 nM). Marked elevation of inflammatory cytokine secretion, increased MDA level, repressed SOD activity, and activated NLRP3 signaling were observed in hypoxia-stimulated PMECs, accompanied by a downregulation of SIRT1. Furthermore, the repressive effect of PHN-20 on the domains-containing protein 3 (NLRP3) pathway in hypoxia-stimulated PMECs was abrogated by sirtuin1 (SIRT1) knockdown. Collectively, PHN-20 alleviated PAH via inhibiting OS and inflammation by mediating the transcriptional function of SIRT1.

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“…Phoenixin (PNX) was first isolated from rat hypothalamus and bovine heart and has been identified in numerous mammals and non-mammals, which is expressed in various central and peripheral tissues and induces the activation of G-protein-coupled receptor (GPR173) [ 16 ]. PNX was speculated to play a role in multiple levels of the hypothalamus-pituitary-gonad (HPG) axis [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

The protective effects of Phoenixin-20 in tumor necrosis factor α (TNF-α)-induced cell senescence of rheumatoid arthritis fibroblast-like synoviocytes (FLS)

Yan,

Yao,

Tan

et al. 2023

Aging

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Rheumatoid arthritis (RA) is an age-related joint destruction disease that markedly impacts the normal life of patients. Currently, the clinical treatment strategies are far from satisfactory with severe side effects. Cellular senescence of fibroblast-like synoviocytes (FLS) has been reported to be involved in the pathological process of arthritis, which may provide an important research direction for RA treatment. Phoenixin-20 (PNX-20) is a peptide targeting G-protein-coupled receptor 173 (GPR173) with promising anti-inflammatory properties. Our study will probe into the function of PNX-20 on tumor necrosis factor α (TNF-α)- induced rheumatoid arthritis (RA) FLS cell senescence to provide a theoretical basis for treating RA with PNX-20. RA-FLSs were handled with 10 ng/mL TNF-α, followed by introducing Phoenixin-20 (10, 20 nM) or not for 7 days. Enhanced release of inflammatory cytokines, increased proportion of senescence-associated β-galactosidase (SA-β-gal) positive cells, and declined telomerase activity were all observed in TNF-α-treated RA-FLSs, accompanied by a noticeable decline in the p21 and p53 level, which were notably reversed by 10 and 20 nM PNX-20. Furthermore, the increased signal transducer and activator of transcription 6 (STAT6) level observed in TNF-α-treated RA-FLSs were signally repressed by PNX-20. Moreover, the impact of PNX-20 on TNF-α-induced cellular senescence in RA-FLSs was abrogated by the overexpression of STAT6. Collectively, PNX-20 protected the TNF-α-induced cell senescence in RA-FLSs by downregulating STAT6. Based on these findings, we speculate that PNX-20 might be a promising agent for the treatment of RA.

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Regulation and physiological functions of phoenixin

Cited by 15 publications

References 79 publications

Investigation of Serum Phoenixin-14 Concentration in Pregnant Women Diagnosed with Hyperemesis Gravidarum

Investigation of Serum Phoenixin-14 Concentration in Pregnant Women Diagnosed with Hyperemesis Gravidarum

Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress

The protective effects of Phoenixin-20 in tumor necrosis factor α (TNF-α)-induced cell senescence of rheumatoid arthritis fibroblast-like synoviocytes (FLS)

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