Regulation and Function of Laminin A5 during Mouse and Human Decidualization

Pan, Hai-Yang; Shi, Wenwen; Chen, Si-Ting; Wang, Ying; Li, Mengyuan; Zhang, Haiyi; Yang, Chen; Liu, Aixia; Yang, Zeng‐Ming

doi:10.3390/ijms23010199

Cited by 9 publications

(9 citation statements)

References 61 publications

(81 reference statements)

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“…Real-time PCR was performed as previously described [ 70 ]. The TRIzol reagent (9109, Takara, Japan) was used for total RNA extraction from cultured cells.…”

Section: Methodsmentioning

confidence: 99%

Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon Receptor

Luo

Zhang

et al. 2023

IJMS

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Decidualization is necessary for the successful establishment of early pregnancy in rodents and humans. Disturbed decidualization results in recurrent implantation failure, recurrent spontaneous abortion, and preeclampsia. Tryptophan (Trp), one of the essential amino acids in humans, has a positive effect on mammalian pregnancy. Interleukin 4-induced gene 1 (IL4I1) is a recently identified enzyme that can metabolize L-Trp to activate aryl hydrocarbon receptor (AHR). Although IDO1-catalyzed kynurenine (Kyn) from Trp has been shown to enhance human in vitro decidualization via activating AHR, whether IL4I1-catalyzed metabolites of Trp are involved in human decidualization is still unknown. In our study, human chorionic gonadotropin stimulates IL4I1 expression and secretion from human endometrial epithelial cells through ornithine decarboxylase-induced putrescine production. Either IL4I1-catalyzed indole-3-pyruvic acid (I3P) or its metabolite indole-3-aldehyde (I3A) from Trp is able to induce human in vitro decidualization by activating AHR. As a target gene of AHR, Epiregulin induced by I3P and I3A promotes human in vitro decidualization. Our study indicates that IL4I1-catalyzed metabolites from Trp can enhance human in vitro decidualization through AHR-Epiregulin pathway.

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“…Real-time PCR was performed as previously described [ 70 ]. The TRIzol reagent (9109, Takara, Japan) was used for total RNA extraction from cultured cells.…”

Section: Methodsmentioning

confidence: 99%

Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon Receptor

Luo

Zhang

et al. 2023

IJMS

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“…As well as collagen IV, laminin may play an essential role in decidualization and invasion and has a remarkable effect on the enhancement of endometrial ECM stiffness. [37,41,42] Fibronectin can be secreted by decidual stromal cells and trophoblasts and is regarded to mediate the migration of trophoblasts. [39] Pathological states in the uterus…”

Section: Regulation Ecm In the Uterusmentioning

confidence: 99%

Extracellular matrix and extracellular matrix-derived materials in reproductive medicine

Gao

Chen

et al. 2023

PRM

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Infertility has become a worldwide issue, and many patients cannot benefit from assisted reproductive technologies (ART). The extracellular matrix (ECM) is critical in tissue organization and remodeling. The female reproductive system plays an important role in menstruation, pregnancy, and ovulation and may influence fertility. In addition, ECM has a wide variety of components, good biological properties, and extensive application experience as a biomaterial. In-depth research on the ECM in the female reproductive system and the development and application of ECM-derived materials may provide new ideas for solving infertility problems. This review aimed to summarize the regulation and changes of ECM in the uterus and ovary, and to discuss the progress of research on ECM-derived materials in reproductive tissue engineering. An extensive search in PubMed and Embase was conducted using keywords including extracellular matrix, uterus, ovary, tissue engineering, and material. We are devoted to combining research on ECM-derived materials with clinical practice and intend to provide ideas for solving clinical problems in reproductive medicine.

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“…Another difference between the mammalian uterus and the glandular uterus of A. sagrei is the presence of a series of acinar structures that are distinct from the keratin 8 positive epithelial ductal structures and defined by the presence of a laminin-positive basement membrane. Though laminins are also expressed in the basement membrane of the endometrial glands of pregnant humans (Yang et al, 2021) and rats (Glasser et al, 1987) as well as pregnant and nonpregnant mice (Jin, 2019;Yang et al, 2021), the acinar structures in the brown anole do not bear much similarity to any of the structures of the mammalian uterus. Instead, they are similar to structures that have been identified in the chicken reproductive tract.…”

Section: Glandular Uterusmentioning

confidence: 99%

Anatomy of the female reproductive tract organs of the brown anole (Anolis sagrei)

Kircher

Stanley

Behringer

2023

The Anatomical Record

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Female reproduction in squamate reptiles (lizards and snakes) is highly diverse and mode of reproduction, clutch size, and reproductive tract morphology all vary widely across this group of ~11,000 species. Recently, CRISPR genome editing techniques that require manipulation of the female reproductive anatomy have been developed in this group, making a more complete understanding of this anatomy essential. We describe the adult female reproductive anatomy of the model reptile the brown anole (Anolis sagrei). We show that the brown anole female reproductive tract has three distinct anterior‐to‐posterior regions, the infundibulum, the glandular uterus, and the nonglandular uterus. The infundibulum has a highly ciliated epithelial lip, a region where the epithelium is inverted so that cilia are present on the inside and outside of the tube. The glandular uterus has epithelial ducts that are patent with a lumen as well as acinar structures with a lumen. The nonglandular uterus has a heterogeneous morphology from anterior to posterior, with a highly folded, ciliated epithelium transitioning to a stratified squamous epithelium. This transition is accompanied by a loss of keratin‐8 expression and together, these changes are similar to the morphological and gene expression changes that occur in the mammalian cervix. We recommend that description of the nonglandular uterus include the regional sub‐specification of a “cervix” and “vagina” as this terminology change more accurately describes the morphology. Our data extend histological studies of reproductive organ morphology in reptiles and expand our understanding of the variation in reproductive system anatomy across squamates and vertebrates.

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Regulation and Function of Laminin A5 during Mouse and Human Decidualization

Cited by 9 publications

References 61 publications

Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon Receptor

Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon Receptor

Extracellular matrix and extracellular matrix-derived materials in reproductive medicine

Anatomy of the female reproductive tract organs of the brown anole (Anolis sagrei)

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