Regulating wound moisture for accelerated healing: A strategy for the continuous drainage of wound exudates by mimicking plant transpiration

Li, Ying; Zhang, Yi; Wang, Yixin; Yu, Kun; Hu, Enling; Lu, Fei; Shang, Songmin; Xie, Ruiqi; Lan, Guangqian

doi:10.1016/j.cej.2021.131964

Cited by 16 publications

(16 citation statements)

References 37 publications

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“…(F) Schematic of the preparation of the self-draining dressing material for exudate management and wound healing. 121 Copyright 2021, Elsevier. (G) Polyionic-liquid gel dressing with antifreeze, nondrying, and adhesion.…”

Section: Microenvironment Change Design Wound Dressingmentioning

confidence: 99%

“…Inspired by plant transpiration, in 2021, Li et al designed a dressing that can adjust wound moisture and temperature (Figure 6F). 121 Even if the external temperature is as high as 53 °C, the dressing can protect the wound from high-temperature damage and maintain the required water content. It can quickly remove too much water.…”

Section: Microenvironment Change Design Wound Dressingmentioning

confidence: 99%

“…To meet different hot and cold environments, intelligent multifunctional dressings suitable for the environment have attracted much attention. Inspired by plant transpiration, in 2021, Li et al designed a dressing that can adjust wound moisture and temperature (Figure F) . Even if the external temperature is as high as 53 °C, the dressing can protect the wound from high-temperature damage and maintain the required water content.…”

Section: Intelligence and Multifunctional Wound Dressingmentioning

confidence: 99%

mentioning

confidence: 99%

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Rational Design of Intelligent and Multifunctional Dressing to Promote Acute/Chronic Wound Healing

Zhou

Min

Bian

et al. 2022

ACS Appl. Bio Mater.

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Currently, the clinic's treatment of acute/chronic wounds is still unsatisfactory due to the lack of functional and appropriate wound dressings. Intelligent and multifunctional dressings are considered the most advanced wound treatment modalities. It is essential to design and develop wound dressings with required functions according to the wound microenvironment in the clinical treatment. This work summarizes microenvironment characteristics of various common wounds, such as acute wound, diabetic wound, burns wound, scalded wound, mucosal wound, and ulcers wound. Furthermore, the factors of transformation from acute wounds to chronic wounds were analyzed. Then we focused on summarizing how researchers fully and thoroughly combined the complex microenvironment with modern advanced technology to ensure the usability and value of the dressing, such as photothermal-sensitive dressings, microenvironment dressing (pH-sensitive dressings, ROSsensitive dressings, and osmotic pressure dressings), hemostatic dressing, guiding tissue regeneration dressing, microneedle dressings, and 3D/4D printing dressings. Finally, the revolutionary development of wound dressings and how to transform the existing advanced functional dressings into clinical needs as soon as possible have carried out a reasonable and meaningful outlook.

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Section: Microenvironment Change Design Wound Dressingmentioning

confidence: 99%

Section: Microenvironment Change Design Wound Dressingmentioning

confidence: 99%

Section: Intelligence and Multifunctional Wound Dressingmentioning

confidence: 99%

mentioning

confidence: 99%

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Rational Design of Intelligent and Multifunctional Dressing to Promote Acute/Chronic Wound Healing

Zhou

Min

Bian

et al. 2022

ACS Appl. Bio Mater.

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“…Recently, there has been growing interest about personal moisture management from natural biological to practical application. It is essential and one of the primary demands for functional textiles for various applications such as outdoor sportswear, worker uniform, military apparel, and medical/health clothing. − Especially in the era of the coronavirus disease 2019 pandemic, when a highly infectious viral disease is yet consistently developing, the demand for comfortable medical protective clothing is on unprecedented rise. Currently, commercially available medical protective clothing is water repellent in nature and provides sufficient protection; however, its inability to allow adequate moisture transport through the fabric results in great discomfort for workers. , In this regard, moisture management textiles with improved perspiration efficiency are considered as a suitable alternative to traditional medical protective clothing because of their inherent characteristic of retaining comfort.…”

Section: Introductionmentioning

confidence: 99%

A Trilayered Composite Fabric with Directional Water Transport and Resistance to Blood Penetration for Medical Protective Clothing

Lin

Wang

Miao

et al. 2022

ACS Appl. Mater. Interfaces

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Functional textiles with enhanced moisture management can facilitate sweat transport away from the skin to improve personal comfort. However, porous materials exhibit low capability of preventing the intrusion of external liquids, becoming a bottleneck in the design of medical protective clothing. Herein, a trilayered composite fabric based on a gradient wettability structure is demonstrated for directional water transport and resistance to blood penetration. The proposed fabric shows distinct advantages, including a high water breakthrough pressure of 2.43 kPa from the external side, an outstanding positive water transport index (1522%), and an antiblood penetration resistance of 2.71 kPa. Moreover, the fabric shows improved comfort with a high moisture transmission (320 g m–2 h–1) and desired water evaporation rate (0.36 g h–1). This work addressed the concern of directional water transport and resistance to blood penetration while providing a comfortable wearing microenvironment, leading to a promising research direction for multifunctional medical textiles.

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Janus Paper‐Based Wound Dressings for Effective Exudate Absorption and Antibiotic Delivery

Gao,

Elhadad,

Choi

2023

Adv Eng Mater

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Traditional hydrophilic wound dressings, while common, fail to effectively drain wound exudate, creating conditions favorable for bacterial growth. Similarly, newer Janus‐type dressings with hydrophobic‐hydrophilic properties also fall short, as their hydrophobic side causes excessive dryness by pulling biofluids from the wound, disrupting moisture balance. Additionally, embedding antibiotics in dressings at fixed concentrations, regardless of the infection type, reduces effectiveness and contributes to the growing problem of antibiotic resistance. In response, a single‐layered Janus paper wound dressing, designed for efficient exudate absorption and precise antibiotic delivery, is developed. The approach differs from traditional Janus‐type dressings; a hydrophilic layer is placed directly against the wound for better moisture management, while antibiotics are applied through the hydrophobic layer. To further enhance exudate management, the hydrophilic section with four extra absorbent pads is extended. The dressing's antibiotic efficacy and dosage are tailored based on antibiotic susceptibility testing, ensuring targeted treatment. The selected antibiotic is manually added but automatically delivered directly to the wound bed. The in vitro and ex vivo evaluations, using bacterial cultures on agar and porcine skin assays, respectively, confirm the dressing's superior exudate drainage and its ability to inhibit pathogen growth and reproduction, marking a significant advancement in wound care.

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Regulating wound moisture for accelerated healing: A strategy for the continuous drainage of wound exudates by mimicking plant transpiration

Cited by 16 publications

References 37 publications

Rational Design of Intelligent and Multifunctional Dressing to Promote Acute/Chronic Wound Healing

Rational Design of Intelligent and Multifunctional Dressing to Promote Acute/Chronic Wound Healing

A Trilayered Composite Fabric with Directional Water Transport and Resistance to Blood Penetration for Medical Protective Clothing

Janus Paper‐Based Wound Dressings for Effective Exudate Absorption and Antibiotic Delivery

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