Regulating traffic in the hematopoietic stem cell niche

Raaijmakers, Marc H.G.P.

doi:10.3324/haematol.2010.027342

Cited by 11 publications

(6 citation statements)

References 20 publications

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“…The third proposed niche is the vascular/sinusoidal niche, where HSCs reside in direct contact with endothelial cells in the venous side of the sinusoids [ 43 ]. It is well known that HSC circulation involves HSCs leaving the BM, entering the vascular system (mobilization), and returning to the BM (homing) [ 44 , 45 ]. The BM vascular structure provides a barrier between the hematopoietic compartment and the peripheral circulation.…”

Section: Mesenchymal Stem Cells Contribute To Hematopoietic Stem Cmentioning

confidence: 99%

Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche

Tian

2011

Bone Marrow Research

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Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are both adult stem cells residing in the bone marrow. MSCs interact with HSCs, they stimulate and enhance the proliferation of HSCs by secreting regulatory molecules and cytokines, providing a specialized microenvironment for controlling the process of hematopoiesis. In this paper we discuss how MSCs contribute to HSC niche, maintain the stemness and proliferation of HSCs, and support HSC transplantation.

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Section: Mesenchymal Stem Cells Contribute To Hematopoietic Stem Cmentioning

confidence: 99%

Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche

Tian

2011

Bone Marrow Research

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“…These cells can produce a CXCL12 gradient, but CXCL12 is also a target for many bone marrow proteases capable of abolishing the chemoattractive activity of CXCL12 including the membrane-bound carboxypeptidase M and MT1-matrix metalloproteinase (MMP), the secreted MMP-9, and different secreted cathepsins [6,[17][18][19][20]. Therefore, proteases of various families and origins seem to be responsible for the fine tuning of this important chemokine gradient [21].…”

Section: Introductionmentioning

confidence: 99%

Processing of CXCL12 by Different Osteoblast-Secreted Cathepsins

Staudt

Maurer²,

Spring³

et al. 2012

Stem Cells and Development

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Hematopoietic stem and progenitor cells (HSPCs) are known to reside in specialized niches at the endosteum in the trabecular bone. Osteoblasts are the major cell type of the endosteal niche. It is well established that secreted proteases are involved in cytokine-induced mobilization processes that release stem cell from their niches. However, migratory processes such as the regular trafficking of HSPCs between their niches and the periphery are not fully understood. In the current study we analyzed whether osteoblast-secreted cysteine cathepsins are able to reduce the direct interaction of HSPCs with bone-forming osteoblasts. Isolated human osteoblasts were shown to secrete proteolytically active cysteine cathepsins, such as cathepsins B, K, L, and X. All of these cathepsins were able to digest, although with different efficacy, the chemokine CXCL12, which is known to be important for retaining HSPCs in their niches. Of the 4 identified cathepsins, only cathepsin X was able to reduce binding of HSPCs to osteoblasts. Interestingly, nonactivated pro-cathepsin X and mature cathepsin X did not interfere with HSPC-osteoblast interactions. Only pro-cathepsin X treated with dithiothreitol, which unfolds but does not lead to full maturation of cathepsin X, significantly reduced HSPC adhesion to osteoblasts. These observations argue for a role of the accessible cathepsin X prodomain in diminishing cell binding. Our findings strongly suggest that the cysteine cathepsins B, K, and L constitutively secreted by osteoblasts are part of the fine-tuned regulation of CXCL12 in the bone marrow, whereas pro-cathepsin X with its prodomain can affect HSPC trafficking in the niche.

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“…Further research is needed to elucidate the specific mechanisms responsible for the differential regulation of adult hematopoiesis throughout the adipocytic differentiation axis, and to determine how deregulation of the adipocytic axis may contribute to the microenvironment-guided initiation or progression of haematopoietic malignancies, as previously demonstrated for osteoblastic and neural-derived signaling within the bone marrow. 37-39 …”

Section: Bmat and Hematopoiesismentioning

confidence: 99%

Meeting report of the 2016 bone marrow adiposity meeting

Eerden

Wijnen

2017

Adipocyte

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There is considerable interest in the physiology and pathology, as well as the cellular and molecular biology, of bone marrow adipose tissue (BMAT). Because bone marrow adiposity is linked not only to systemic energy metabolism, but also to both bone marrow and musculoskeletal disorders, this biologic compartment has become of major interest to investigators from diverse disciplines. Bone marrow adiposity represents a virtual multi-tissue endocrine organ, which encompasses cells from multiple developmental lineages (e.g., mesenchymal, myeloid, lymphoid) and occupies all the non-osseous and non-cartilaginous space within long bones. A number of research groups are now focusing on bone marrow adiposity to understand a range of clinical afflictions associated with bone marrow disorders and to consider mechanisms-based strategies for future therapies.

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Regulating traffic in the hematopoietic stem cell niche

Cited by 11 publications

References 20 publications

Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche

Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche

Processing of CXCL12 by Different Osteoblast-Secreted Cathepsins

Meeting report of the 2016 bone marrow adiposity meeting

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