2020
DOI: 10.1155/2020/8148272
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Regulating the Polarization of Macrophages: A Promising Approach to Vascular Dermatosis

Abstract: Macrophages, a kind of innate immune cells, derive from monocytes in circulation and play a crucial role in the innate and adaptive immunity. Under the stimulation of the signals from local microenvironment, macrophages generally tend to differentiate into two main functional phenotypes depending on their high plasticity and heterogeneity, namely, classically activated macrophage (M1) and alternatively activated macrophage (M2). This phenomenon is often called macrophage polarization. In pathological condition… Show more

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Cited by 29 publications
(20 citation statements)
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“…The innate immune defense system plays a key protective role in the growth of infants and young children ( Yu et al, 2018 ). As expected, innate immunity is widespread in IH ( Ritter et al, 2006 ; Peng et al, 2020 ). Promoting cell cycle arrest and apoptosis are the main mechanisms of action of drugs for the treatment of IH ( Chen et al, 2019 ).…”
Section: Discussionsupporting
confidence: 75%
“…The innate immune defense system plays a key protective role in the growth of infants and young children ( Yu et al, 2018 ). As expected, innate immunity is widespread in IH ( Ritter et al, 2006 ; Peng et al, 2020 ). Promoting cell cycle arrest and apoptosis are the main mechanisms of action of drugs for the treatment of IH ( Chen et al, 2019 ).…”
Section: Discussionsupporting
confidence: 75%
“…In many cancers, tumor associated macrophages (TAM) acquire an M2-like fate that promotes metastasis by enhancing angiogenesis and ECM remodeling ( 56 , 57 ). Given the strong correlation between the macrophage fate acquisition and the disease progression, there is increasing focus on understanding the critical mediators that drive macrophage polarization states in order to develop targets for therapeutic interventions ( 58 ). For example, COX2 is required for the polarization of macrophages to an M2 state and several studies have reported that blocking the COX2 mediated inflammation using celecoxib treatment improves disease prognosis in the diseases discussed ( 59 , 60 ).…”
Section: Discussionmentioning
confidence: 99%
“…The current research found a positive correlation between M1 and M2, which is contradictory to some previous literature, which is quite variable. Some studies found negative correlation between M1 and M2 by showing that the promotion of M2 macrophage polarization could suppress the M1 macrophage polarization, and vice versa, the inhibition of M2 macrophage polarization could promote the M1 macrophage polarization ( Abdelaziz et al, 2020 ; Peng et al, 2020 ). However, a previous study regarding breast cancer found a weak correlation between M1 and M2 macrophage densities in central tumor tissue of breast cancer ( Schnellhardt et al, 2020 ).…”
Section: Discussionmentioning
confidence: 99%