Regulating the bacterial oxygen microenvironment via a perfluorocarbon-conjugated bacteriochlorin for enhanced photodynamic antibacterial efficacy

Wu, Meng-Si; Chen, Chao; Li, Yong; Tian, Jia

doi:10.1016/j.actbio.2022.02.013

Cited by 23 publications

(21 citation statements)

References 51 publications

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“…Overall, the results suggest that both sp 2 c‐COF‐Ir‐ppy 2 and sp 2 c‐COF‐Ru‐bpy 2 are capable of oxidizing TMB under 635 nm irradiation, and the former exhibits higher activity than sp 2 c‐COF‐Ru‐bpy 2 due to extra POD‐like activity. Furthermore, dihydroethidium (DHE), which can solely react with superoxide anion (O 2 •− ), [ 36 ] was investigated with the three kinds of COFs (Figure 4d). The fluorescence emission spectra of DHE at 610 nm indicate that the production rate of O 2 •− for sp 2 c‐COF‐Ir‐ppy 2 is 1.4‐fold higher than that of sp 2 c‐COF‐Ru‐bpy 2 , highlighting the former's much greater ability in O 2 •− production.…”

Section: Resultsmentioning

confidence: 99%

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Designing Single‐Atom Active Sites on sp²‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy

Zhang

Chen

et al. 2023

Advanced Science

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With the threat posed by drug‐resistant pathogenic bacteria, developing non‐antibiotic strategies for eradicating clinically prevalent superbugs remains challenging. Ferroptosis is a newly discovered form of regulated cell death that can overcome drug resistance. Emerging evidence shows the potential of triggering ferroptosis‐like for antibacterial therapy, but the direct delivery of iron species is inefficient and may cause detrimental effects. Herein, an effective strategy to induce bacterial nonferrous ferroptosis‐like by coordinating single‐atom metal sites (e.g., Ir and Ru) into the sp2‐carbon‐linked covalent organic framework (sp2c‐COF‐Ir‐ppy2 and sp2c‐COF‐Ru‐bpy2) is reported. Upon activating by light irradiation or hydrogen peroxide, the as‐constructed Ir and Ru single‐atom catalysts (SACs) can significantly expedite intracellular reactive oxygen species burst, enhance glutathione depletion‐related glutathione peroxidase 4 deactivation, and disturb the nitrogen and respiratory metabolisms, leading to lipid peroxidation‐driven ferroptotic damage. Both SAC inducers show potent antibacterial activity against Gram‐positive bacteria, Gram‐negative bacteria, clinically isolated methicillin‐resistant Staphylococcus aureus (MRSA), and biofilms, as well as excellent biocompatibility and strong therapeutic and preventive potential in MRSA‐infected wounds and abscesses. This delicate nonferrous ferroptosis‐like strategy may open up new insights into the therapy of drug‐resistant pathogen infection.

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Section: Resultsmentioning

confidence: 99%

“…•− ), [36] was investigated with the three kinds of COFs (Figure 4d). The fluorescence emission spectra of DHE at 610 nm indicate that the production rate of O 2…”

Section: Ros Generationmentioning

confidence: 99%

Designing Single‐Atom Active Sites on sp²‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy

Zhang

Chen

et al. 2023

Advanced Science

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“…With the advancement of optical technology and the development of new photosensitizers, photodynamic therapy (PDT) has recaptured the attention of researchers because of its advantage of not easily developing drug resistance. It can effectively produce a great deal of reactive oxygen species (ROS), improve the antibacterial effect, and provide a promising method for eliminating biofilm, becoming one of the most promising treatments for drug-resistant bacterial infection [54,55]. It was reported more than a decade ago that melanin might have redox activity that could sustain ROS generation by catalyzing electron transfer from the endogenous extracellular domain to O 2 , thereby providing an additional active antimicrobial mechanism [56].…”

Section: Photodynamic Antibacterial Therapymentioning

confidence: 99%

Recent Development of Polydopamine Anti-Bacterial Nanomaterials

Wang

Liu

2022

IJMS

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Polydopamine (PDA), as a mussel-inspired material, exhibits numerous favorable performance characteristics, such as a simple preparation process, prominent photothermal transfer efficiency, excellent biocompatibility, outstanding drug binding ability, and strong adhesive properties, showing great potential in the biomedical field. The rapid development of this field in the past few years has engendered substantial progress in PDA antibacterial materials. This review presents recent advances in PDA-based antimicrobial materials, including the preparation methods and antibacterial mechanisms of free-standing PDA materials and PDA-based composite materials. Furthermore, the urgent challenges and future research opportunities for PDA antibacterial materials are discussed.

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“…[3][4][5] NO and CO are capable of directly killing pathogens at micromolar or millimolar levels, whereas bacterial clearance using O 2 can be achieved via the production of reactive oxygen species (ROS). [6][7][8][9] Such gas-based therapeutic is becoming a promising strategy for inhibiting bacterial infection without the risk of generating resistance. [10][11][12] Despite their promise, the precise delivery of therapeutic gases to pathogens without inducing Biomimetic nanobubbles for the "on-demand" photodynamic therapy (PDT) of bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Toxin‐Responsive Biomimetic Nanobubbles for Precision Photodynamic Therapy against Bacterial Infections

ZhuGe

Wang

et al. 2022

Adv Healthcare Materials

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With few options available for the effective treatment of multidrug‐resistant bacteria, photodynamic therapy (PDT) has emerged as a promising therapeutic strategy that does not promote the development of antibiotic resistance. Unfortunately, the beneficial bactericidal effect of PDT is oftentimes accompanied by the uncontrollable production of reactive oxygen species. To overcome this issue, a pore‐forming toxin (PFT)‐responsive biomimetic nanobubble is designed, which is constructed by co‐encapsulating a perfluorocarbon nanoemulsion and a photosensitizer within the red blood cell membrane. It is shown that PFTs derived from three pathogens, including methicillin‐resistant Staphylococcus aureus (MRSA), group A Streptococcus (GAS), and Listeria monocytogenes (LM), can be effectively absorbed by the nanobubble. Upon toxin absorption, the formation of pores on the nanobubble surface allows the accelerated release of oxygen dissolved inside the nanoemulsion along with the photosensitizer, thus resulting in enhanced PDT and bactericidal efficacy. In three skin infection models, treatment with the nanobubbles results in significantly decreased lesion formation and reduced inflammation. In addition to oxygen, the platform can be used to deliver nitric oxide in a bacterial toxin‐dependent manner. Overall, biomimetic nanobubbles may work as a broad gas delivery system that is capable of responding to a variety of PFT‐based stimuli for precision PDT.

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Regulating the bacterial oxygen microenvironment via a perfluorocarbon-conjugated bacteriochlorin for enhanced photodynamic antibacterial efficacy

Cited by 23 publications

References 51 publications

Designing Single‐Atom Active Sites on sp²‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy

Designing Single‐Atom Active Sites on sp²‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy

Recent Development of Polydopamine Anti-Bacterial Nanomaterials

Bacterial Toxin‐Responsive Biomimetic Nanobubbles for Precision Photodynamic Therapy against Bacterial Infections

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Regulating the bacterial oxygen microenvironment via a perfluorocarbon-conjugated bacteriochlorin for enhanced photodynamic antibacterial efficacy

Cited by 23 publications

References 51 publications

Designing Single‐Atom Active Sites on sp2‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy

Designing Single‐Atom Active Sites on sp2‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy

Recent Development of Polydopamine Anti-Bacterial Nanomaterials

Bacterial Toxin‐Responsive Biomimetic Nanobubbles for Precision Photodynamic Therapy against Bacterial Infections

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Product

Resources

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Designing Single‐Atom Active Sites on sp²‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy

Designing Single‐Atom Active Sites on sp²‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy