Regulating structural and mechanical properties of pectin reinforced liposomes at fluid/solid interface

Bhargavi, N.; Dhathathreyan, Aruna; Sreeram, Kalarical Janardhanan

doi:10.1016/j.foodhyd.2020.106225

Cited by 12 publications

(4 citation statements)

References 43 publications

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“…The shift of the P=O vibration in the spectral position in the FTIR spectra indicated that there was H-bonding. This observation was similar to other reports that inulin might form hydrogen bonds with liposomes [14,34]. The spectral width of the liposomes decreased after being modified with inulin, indicating that the fluidity of the modified membrane was reduced and the stability of the modified liposomes was enhanced [10].…”

Section: Fourier Transform Infrared (Ftir) Spectroscopy Analysissupporting

confidence: 91%

Inulin-Modified Liposomes as a Novel Delivery System for Cinnamaldehyde

Xue

Wang

Huang

2022

Foods

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Cinnamaldehyde as an antioxidant was encapsulated in inulin-modified nanoliposomes in order to improve its physical and antioxidant stability. The microstructure, particle size and volume distribution of cinnamaldehyde liposomes were characterized by atomic force microscopy (AFM) and dynamic light scattering (DLS). The particle size and polydispersion index (PDI) values of the inulin modified liposomes were 72.52 ± 0.71 nm and 0.223 ± 0.031, respectively. The results showed that the liposomes after surface modification with inulin remained spherical. Raman and Fourier transform infrared (FTIR) spectra analysis showed that hydrogen bonds were formed between the inulin and the liposome membrane. Inulin binding also restricted the freedom of movement of lipid molecules and enhanced the order of the hydrophobic core of the membrane and the polar headgroup region in lipid molecules. Therefore, the addition of different concentrations of inulin influenced the permeability of the liposome bilayer membrane. However, when inulin was excessive, the capacity of the bilayer membrane to load the cinnamaldehyde was reduced, and the stability of the system was reduced. Additionally, the encapsulation efficiency (EE) and retention rate (RR) of cinnamaldehyde from inulin-modified liposomes during storage were determined. The EE value of the inulin modified liposomes was 70.71 ± 0.53%. The liposomes with 1.5% inulin concentration had the highest retention rate (RR) and the smallest particle size during storage at 4 °C. The addition of inulin also enhanced the thermal stability of the liposomes. Based on the results, the surface modification improved the oxidation stability of liposomes, especially the DPPH scavenging ability. In conclusion, these results might help to develop inulin as a potential candidate for the effective modification of the surface of liposomes and provide data and conclusions for it.

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Section: Fourier Transform Infrared (Ftir) Spectroscopy Analysissupporting

confidence: 91%

Inulin-Modified Liposomes as a Novel Delivery System for Cinnamaldehyde

Xue

Wang

Huang

2022

Foods

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“…Such a pattern has been reported previously for liposomes. [ 39a,40 ] To demonstrate the encapsulation potential of the Fm‐GPO vesicles, an uncharged phenoxazone dye, Nile red, was encapsulated using a reported method with slight modification. [ 41 ] On excitation of a solution containing Nile red‐encapsulated inside 1.56 mM Fm‐GPO vesicles (λ ex = 550 nm), maximum emission was observed around 578 nm (Figure 6d), as reported for other Nile red‐encapsulated systems.…”

Section: Resultsmentioning

confidence: 99%

A Novel Surfactant with Short Hydrophobic Head and Long Hydrophilic Tail Generates Vesicles with Unique Structural Feature

Mukherjee

Shanmugam

2023

Small

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Surfactant molecules typically have a long hydrophobic tail and a short hydrophilic head group. It remains unexplored if surfactants can have a short hydrophobic head group and a long hydrophilic tail. Designing such surfactants is a challenge as a lengthy hydrophilic tail would completely solubilize the molecules. In this context, herein, the Fmoc‐functionalized Gly‐Pro‐Hyp (GPO) tripeptide repeat‐based molecule (Fm‐GPO) with fluorenyl moiety as a short hydrophobic head and peptide as a long hydrophilic tail is demonstrated as a reverse surfactant at physiological pH, for the first time. π–π stacking of the fluorenyl moieties and intermolecular hydrogen bonding between the peptide chains with extended polyproline‐II structure promoted the self‐assembly into spherical vesicles with a unique feature of a large hydrophilic area in the interior and exterior of the bilayer. The current Fm‐GPO system offers a new class of surfactants with unique features that can aid in the design of drug‐loaded vehicles, which can be target‐specific as the peptide chain can be manipulated with different functional ultra‐short peptide sequences.

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“…The spectra were recorded in the transmittance mode at a scan resolution of 4 cm −1 and wavelength range of 4000–400 cm −1 . [ 21 ]…”

Section: Methodsmentioning

confidence: 99%

Preparation, Characterization, and Gastrointestinal Digestion of Triterpenol‐Loaded Liposomes

Sun

Guo

Liu

et al. 2023

Euro J Lipid Sci & Tech

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Triterpenol is an important phytochemical that is beneficial to humans. However, there are limitations of application due to its poor solubility. Liposomes are increasingly utilized as a delivery system for phytochemicals with poor solubility which is suitable for triterpenol. In the present study, the stability of triterpenol‐loaded liposomes (Tri‐LP) is demonstrated. Tri‐LP stability is observed when the mass ratio of phospholipids to triterpenol is 4:1. Sodium alginate (ALG) and chitosan showed different effects on Tri‐LP. Tri‐LP coated by ALG (Tri‐LP‐ALG) is stabilized by H‐bonding, while electrostatic interactions can stabilize Tri‐LP coated by chitosan (Tri‐LP‐CH). Tri‐LP‐ALG is more stable than Tri‐LP‐CH during storage. The bioaccessibility of Tri‐LP is 11%. ALG and chitosan show no influence on bioaccessibility of Tri‐LP, but reduce the release rate of triterpenol during digestion. Overall, the findings suggest that Tri‐LP showed good promise for future application in functional beverages. Practical Applications: Triterpenol has poor solubility both in oil and water, which greatly limits the functional utilization of triterpene in organisms. Liposomes offer a novel approach to triternenol oral delivery system. It meets the current demands for food health. Liposomes can improve the absorption and utilization of triterpenol in vivo digestion. Many studies and applications of liposomes has carried out in medical field while nutritional supplements with liposomes technology are not common in the market. Triterpenol‐loaded liposomes can not only increase applications in phytochemicals with poor absorption but also offer an interesting attempt of liposomes in food development.

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Regulating structural and mechanical properties of pectin reinforced liposomes at fluid/solid interface

Cited by 12 publications

References 43 publications

Inulin-Modified Liposomes as a Novel Delivery System for Cinnamaldehyde

Inulin-Modified Liposomes as a Novel Delivery System for Cinnamaldehyde

A Novel Surfactant with Short Hydrophobic Head and Long Hydrophilic Tail Generates Vesicles with Unique Structural Feature

Preparation, Characterization, and Gastrointestinal Digestion of Triterpenol‐Loaded Liposomes

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