Regulating Stem Cell-Related Genes Induces the Plastic Differentiation of Cancer Stem Cells to Treat Breast Cancer

Zhang, Jingying; Luo, Qian; Xu, Jiaxi; Bai, Jing; Mu, Li-Min; Yan, Yan; Duan, Jingli; Cui, Yanjun; Su, Zhan-Bo; Xie, Ying; Lü, Wan-Liang

doi:10.1016/j.omto.2020.07.009

Cited by 8 publications

(4 citation statements)

References 44 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Salinomycin increases the apoptosis of BC mammosphere cells, which is accompanied by downregulation of Bcl-2 expression, and decreases their migration capacity, which is accompanied by downregulation of c-Myc and Snail expression (23). Furthermore, extensive studies on BCSCs have established that salinomycin decreases CSC population (32)(33)(34). Global gene expression analyses have shown that salinomycin inhibits the expression of BCSC genes (13).…”

Section: Effects Of Salinomycin On Bcscsmentioning

confidence: 99%

Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications

et al. 2021

View full text Add to dashboard Cite

Breast cancer (BC) is the most frequent cancer among women worldwide and is the leading cause of cancer-related deaths in women. Cancer cells with stem cell-like features and tumor-initiating potential contribute to drug resistance, tumor recurrence, and metastasis. To achieve better clinical outcomes, it is crucial to eradicate both bulk BC cells and breast cancer stem cells (BCSCs). Salinomycin, a monocarboxylic polyether antibiotic isolated from Streptomyces albus, can precisely kill cancer stem cells (CSCs), particularly BCSCs, by various mechanisms, including apoptosis, autophagy, and necrosis. There is increasing evidence that salinomycin can inhibit cell proliferation, invasion, and migration in BC and reverse the immune-inhibitory microenvironment to prevent tumor growth and metastasis. Therefore, salinomycin is a promising therapeutic drug for BC. In this review, we summarize established mechanisms by which salinomycin protects against BC and discuss its future clinical applications.

show abstract

Section: Effects Of Salinomycin On Bcscsmentioning

confidence: 99%

Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications

et al. 2021

View full text Add to dashboard Cite

show abstract

“…SNAI2 has been established as a major regulator of function and differentiation of both adult stem cells and progenitor cells in hematopoietic lineages, 37 breast tissues, 38 cancer stem cells, 39 epidermal cells, 40 and mesenchymal tissues 32 . Through specific regulatory roles in MSCs, SNAIs exert their functions outside of EMT‐related programs.…”

Section: The Snai Family Contributes To Stem Cell Maintenance and Dif...mentioning

confidence: 99%

Functions of the SNAI family in chondrocyte‐to‐osteocyte development

Razmara

Bitaraf

Karimi

et al. 2021

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Different cellular mechanisms contribute to osteocyte development. And while critical roles for members of the zinc finger protein SNAI family (SNAIs) have been discussed in cancer‐related models, there are few reviews summarizing their importance for chondrocyte‐to‐osteocyte development. To help fill this gap, we review the roles of SNAIs in the development of mature osteocytes from chondrocytes, including the regulation of chondro‐ and osteogenesis through different signaling pathways and in programmed cell death. We also discuss how epigenetic factors—including DNA methylation, histone methylation and acetylation, and noncoding RNAs—contribute differently to both chondrocyte and osteocyte development. To better grasp the important roles of SNAIs in bone development, we also review genotype–phenotype correlations in different animal models. We end with comments about the possible importance of the SNAI family in cartilage/bone development and the potential applications for therapeutic goals.

show abstract

“…Various stem cell types have been validated and can be stratified into 3 main types: adult, induced multipotential, and embryonic stem cells (ESCs). 2 …”

Section: Introductionmentioning

confidence: 99%

The Impact of Cellular Therapies on Gastrointestinal Diseases: Applications and Challenges

Zhang¹,

Hu²,

Xu³

et al. 2023

Turk J Gastroenterol

View full text Add to dashboard Cite

Gastrointestinal diseases are highly prevalent, and their burden significantly impacts the quality of life of affected individuals. Inflammatory and immune-mediated intestinal diseases usually have a chronic course without adequate therapeutic modalities. Although much has been reported to comprehend these diseases, many remain resistant and refractory to conventional treatment approaches. Therefore, recent approaches to cellular therapy using stem cells, like hematopoietic stem cells and mesenchymal stem cells, and other cellular immunosuppressive modalities, like T-regulatory cells, were introduced and investigated in treating gastrointestinal diseases. We aimed to conduct a literature review to discuss the applications and challenges of cellular therapeutics in gastrointestinal diseases. Evidence from published clinical trials supports the safety and efficacy of cellular treatment in different immune-mediated and inflammatory gastrointestinal diseases. They can offer a longer duration of remission, being able to adjust the dysregulated immune system. However, there are various challenges to be considered by future trials, including the limitations of current clinical trials, challenges in retrieval and application of these therapeutics, and their mutagenesis potential.

show abstract

Regulating Stem Cell-Related Genes Induces the Plastic Differentiation of Cancer Stem Cells to Treat Breast Cancer

Cited by 8 publications

References 44 publications

Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications

Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications

Functions of the SNAI family in chondrocyte‐to‐osteocyte development

The Impact of Cellular Therapies on Gastrointestinal Diseases: Applications and Challenges

Contact Info

Product

Resources

About