Abstract:Intrinsic signals and cues from the external environment drive cell fate decisions.In budding yeast, the decision to enter meiosis is controlled by nutrient and matingtype signals that regulate expression of the master transcription factor for meiotic entry, IME1. How nutrient signals control IME1 expression remains poorly understood. Here we show that IME1 transcription is regulated by multiple sequence-specific transcription factors that mediate association of Tup1-Cyc8 corepressor to its promoter. We find t… Show more
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