2009
DOI: 10.1073/pnas.0905414106
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Regulated and aberrant glycosylation modulate cardiac electrical signaling

Abstract: Millions afflicted with Chagas disease and other disorders of aberrant glycosylation suffer symptoms consistent with altered electrical signaling such as arrhythmias, decreased neuronal conduction velocity, and hyporeflexia. Cardiac, neuronal, and muscle electrical signaling is controlled and modulated by changes in voltage-gated ion channel activity that occur through physiological and pathological processes such as development, epilepsy, and cardiomyopathy. Glycans attached to ion channels alter channel acti… Show more

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Cited by 101 publications
(90 citation statements)
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References 49 publications
(59 reference statements)
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“…Glycopeptides from voltage-gated and other ion transporters were up-regulated following 40I/20R. Changes in ion channel glycosylation have been associated with altered electrical signaling (23) and changes in sialic acids of voltage-gated sodium channel (Na v ) have been linked with cardiac conduction disorders and heart failure (22,24). A number of ␣ and ␤ subunits are expressed: Na v1.1 , 1.3 , 1.4 , 1.5 and Na v1.6 ; however, Na v1.5 is the major subunit in the sarcolemma and is primarily responsible for the action potential in ventricular systole (65).…”
Section: Discussionmentioning
confidence: 90%
See 1 more Smart Citation
“…Glycopeptides from voltage-gated and other ion transporters were up-regulated following 40I/20R. Changes in ion channel glycosylation have been associated with altered electrical signaling (23) and changes in sialic acids of voltage-gated sodium channel (Na v ) have been linked with cardiac conduction disorders and heart failure (22,24). A number of ␣ and ␤ subunits are expressed: Na v1.1 , 1.3 , 1.4 , 1.5 and Na v1.6 ; however, Na v1.5 is the major subunit in the sarcolemma and is primarily responsible for the action potential in ventricular systole (65).…”
Section: Discussionmentioning
confidence: 90%
“…Modulation of ion channel glycosylation is implicated in altering electrical signaling in the heart (23) and has been linked with cardiac conduction disorders and heart failure (22,24). There is also growing evidence that extracellular glycosidase activity modifies surface glycans and alters protein function.…”
mentioning
confidence: 99%
“…Glycosidase gel shift data were analyzed using the Quantity One one-dimensional gel analysis software (Bio-Rad), as described previously (32). (26).…”
Section: Methodsmentioning
confidence: 99%
“…To question whether K v 2.1, K v 4.2, and K v 4.3 are O-glycosylated and sialylated, we employed previously used methods of glycosidase gel shift analysis (10,14,32,33). Fig.…”
Section: K V 21 K V 42 and K V 43 Channels Are O-glycosylated Andmentioning
confidence: 99%
“…Vertebrate voltage-gated Na ϩ channels, the major determinants of neural excitability, are heavily sialylated, which affects their gating properties in vitro (Recio-Pinto et al, 1990;Bennett, 2002). The role of sialylation in the regulation of these channels has been mostly attributed to a large negative charge due to the channels' prominent polysialylation (Zuber et al, 1992;Montpetit et al, 2009). However, polysialylation and sialylation appear to have different effects on voltage-gated Na ϩ channels, and the regulation of these channels was shown to be affected by some "functional" Sia residues rather than their total charge (Stocker and Bennett, 2006;Ahrens et al, 2011).…”
Section: Introductionmentioning
confidence: 99%