“…Other approaches are based on graph regularization (Belkin et al, 2004;Delalleau et al, 2005), and on the exploitation of the properties of the graph Laplacian associated to the weight matrix of the graph (Belkin & Niyogi, 2003). Methods based on the amount of functional flow through the nodes (Nabieva et al, 2005), on global graph consistency (Vazquez et al, 2003;Karaoz et al, 2004), on Markov and Gaussian Random Fields (Tsuda et al, 2005;Mostafavi et al, 2008), and recently on kernelized score functions have been applied to the predic-tion of gene functions.…”