Regular theta‐firing neurons in the nucleus incertus during sustained hippocampal activation

Martínez-Bellver, Sergio; Cervera‐Ferri, Ana; Martínez‐Ricós, Joana; Ruiz‐Torner, Amparo; Luque-García, Aina; Blasco‐Serra, Arantxa; Guerrero, Juan; Bataller-Mompeán, Manuel; Teruel‐Martí, Vicent

doi:10.1111/ejn.12934

Cited by 13 publications

(23 citation statements)

References 1 publication

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“…NI neurons ( n = 56) were classified following the criteria used in Martínez‐Bellver et al . (). Given the conversion from single‐unit events into the SDF, we characterised the oscillatory pattern of the SDF in the 15 s window after tail pinch.…”

Section: Resultsmentioning

confidence: 97%

“…The first group is a reanalysis of a subset of data which appeared in a previously published study that focused on the single‐unit characterisation of NI neurons coupled to hippocampal theta rhythmicity (Martínez‐Bellver et al . ). This group included 56 cases of well‐isolated single units in conjunction with simultaneously recorded local field potential (LFP) signals.…”

Section: Methodsmentioning

confidence: 97%

“…The methods used to acquire electrophysiological recordings have been previously described in detail (Martínez‐Bellver et al . ). Briefly, the hippocampal LFP was recorded with a steel Teflon‐coated monopolar macroelectrode (120 μm diameter; World Precision Instruments, Aston, Stevenage, UK), placed at the CA1 region of the hippocampus and referenced against an indifferent electrode placed in the cerebellar epidural space.…”

Section: Methodsmentioning

confidence: 97%

“…The nomenclature follows that previously described in Martínez‐Bellver et al . (). [Colour figure can be viewed at wileyonlinelibrary.com]…”

Section: Methodsmentioning

confidence: 97%

“…) and, more specifically, a subpopulation of NI neurons shows theta firing coupled to hippocampal theta waves (Martínez‐Bellver et al . ). Studies by other groups have evidenced a proportion of NI neurons whose firing is coupled to the hippocampal theta after the local infusion of corticotropin‐releasing hormone (CRH) in the NI itself (Ma et al .…”

Section: Introductionmentioning

confidence: 97%

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Causal relationships between neurons of the nucleus incertus and the hippocampal theta activity in the rat

Martínez-Bellver

Cervera‐Ferri

Luque-García

et al. 2017

The Journal of Physiology

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In recent years, a body of evidence has shown that the nucleus incertus (NI), in the dorsal tegmental pons, is a key node of the brainstem circuitry involved in hippocampal theta rhythmicity. Ascending reticular brainstem system activation evokes hippocampal theta rhythm with coupled neuronal activity in the NI. In a recent paper, we showed three populations of neurons in the NI with differential firing during hippocampal theta activation. The objective of this work was to better evaluate the causal relationship between the activity of NI neurons and the hippocampus during theta activation in order to further understand the role of the NI in the theta network. A Granger causality analysis was run to determine whether hippocampal theta activity with sensory-evoked theta depends on the neuronal activity of the NI, or vice versa. The analysis showed causal interdependence between the NI and the hippocampus during theta activity, whose directional flow depended on the different neuronal assemblies of the NI. Whereas type I and II NI neurons mainly acted as receptors of hippocampal information, type III neuronal activity was the predominant source of flow between the NI and the hippocampus in theta states. We further determined that the electrical activation of the NI was able to reset hippocampal waves with enhanced theta-band power, depending on the septal area. Collectively, these data suggest that hippocampal theta oscillations after sensory activation show dependence on NI neuron activity, which could play a key role in establishing optimal conditions for memory encoding.

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Section: Resultsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 97%

“…The nomenclature follows that previously described in Martínez‐Bellver et al . (). [Colour figure can be viewed at wileyonlinelibrary.com]…”

Section: Methodsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

Causal relationships between neurons of the nucleus incertus and the hippocampal theta activity in the rat

Martínez-Bellver

Cervera‐Ferri

Luque-García

et al. 2017

The Journal of Physiology

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Afferent and efferent connections of the interpeduncular nucleus with special reference to circuits involving the habenula and raphe nuclei

Lima

Bueno

Leite

et al. 2017

J of Comparative Neurology

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The habenula is an epithalamic structure differentiated into two nuclear complexes, medial (MHb) and lateral habenula (LHb). Recently, MHb together with its primary target, the interpeduncular nucleus (IP), have been identified as major players in mediating the aversive effects of nicotine. However, structures downstream of the MHb-IP axis, including the median (MnR) and caudal dorsal raphe nucleus (DRC), may contribute to the behavioral effects of nicotine. The afferent and efferent connections of the IP have hitherto not been systematically investigated with sensitive tracers. Thus, we placed injections of retrograde or anterograde tracers into different IP subdivisions or the MnR and additionally examined the transmitter phenotype of major IP and MnR afferents by combining retrograde tract tracing with immunofluorescence and in situ hybridization techniques. Besides receiving inputs from MHb and also LHb, we found that IP is reciprocally interconnected mainly with midline structures, including the MnR/DRC, nucleus incertus, supramammillary nucleus, septum, and laterodorsal tegmental nucleus. The bidirectional connections between IP and MnR proved to be primarily GABAergic. Regarding a possible topography of IP outputs, all IP subnuclei gave rise to descending projections, whereas major ascending projections, including focal projections to ventral hippocampus, ventrolateral septum, and LHb originated from the dorsocaudal IP. Our findings indicate that IP is closely associated to a distributed network of midline structures that modulate hippocampal theta activity and forms a node linking MHb and LHb with this network, and the hippocampus. Moreover, they support a cardinal role of GABAergic IP/MnR interconnections in the behavioral response to nicotine.

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Regular theta‐firing neurons in the nucleus incertus during sustained hippocampal activation

Cited by 13 publications

References 1 publication

Causal relationships between neurons of the nucleus incertus and the hippocampal theta activity in the rat

Causal relationships between neurons of the nucleus incertus and the hippocampal theta activity in the rat

Afferent and efferent connections of the interpeduncular nucleus with special reference to circuits involving the habenula and raphe nuclei

Huygens synchronization of medial septal pacemaker neurons generates hippocampal theta oscillation

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