Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease

Belaya, Irina; Kucháriková, Nina; Górová, Veronika; Kysenius, Kai; Hare, Dominic J.; Crouch, Peter J.; Malm, Tarja; Atalay, Mustafa; White, Anthony R.; Liddell, Jeffrey R.

doi:10.3390/ijms22168715

Cited by 14 publications

(9 citation statements)

References 81 publications

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“…We found that cognitive performance was influenced by physical inactivity (“Delayed memory” domain) and hypertension status (“Attention” domain and total cognition score). The beneficial influence of physical activity on cognition might be due to increased cerebral blood flow positively affecting neuronal plasticity and memory ( Belaya et al, 2021 ). It has been suggested that both cognitive and physical exercise training may be useful to influence age-related cognitive abilities ( Jardim et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

The effect of risk factors on cognition in adult cochlear implant candidates with severe to profound hearing loss

et al. 2022

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Hearing loss has been identified as a major modifiable risk factors for dementia. Adult candidates for cochlear implantation (CI) represent a population at risk of hearing loss-associated cognitive decline. This study investigated the effect of demographics, habits, and medical and psychological risk factors on cognition within such a cohort. Data from 34 consecutive adults with post-lingual deafness scheduled for CI were analyzed. Pure tone audiometry (PTA4) and Speech Discrimination Score (SDS) were recorded. The Repeatable Battery for Assessment of Neuropsychological Status for Hearing impaired individuals (RBANS-H) was used to measure cognition. Demographics (sex, age, years of education), habits (smoking, alcohol intake, physical inactivity), and medical factors (hypertension, diabetes, traumatic brain injury) were evaluated. Depression was measured using the Hospital Anxiety and Depression Scale (HADS), and social inhibition with the Type D questionnaire (DS14). All participants (mean age 62 ± 15 years) suffered from severe to profound hearing loss (PTA4:129 ± 60 dB; SDS:14 ± 24%). The mean RBANS-H total score was 83 ± 16. Participants reported a mean of years of formal education of 12 ± 5 years. The prevalence of habits and medical risk factors was: physical inactivity (29%), body mass index >30 (28%), traumatic brain injury (25%), hypertension (24%), heavy alcohol consumption (13%), smoking (13%), and diabetes (0%). Regarding psychological factors, the mean scores of social inhibition and depression were 10 ± 6 and 6 ± 5, respectively. The number of years of education was significantly correlated with the RBANS-H total score (p < 0.001), and with the domains “Immediate memory” (p = 0.003), “Visuospatial/constructional” (p < 0.001), and “Attention” (p < 0.001). The mean RBANS-H total score in participants who had university studies or higher level (12/34) was 97 ± 9, with the remaining participants reporting a mean score of 75 ± 15. Men performed better in the “Visuospatial/constructional” (p = 0.008). Physical inactivity was associated with lower scores in the “Delayed memory” (p = 0.031); hypertension correlated with lower RBANS-H total scores (p = 0.025) and “Attention” (p = 0.006). Depression and social inhibition were negatively correlated with RBANS-H total score and with the “Immediate memory,” “Visuospatial/constructional,” and “Attention” (all p < 0.05). In adults with late-onset deafness scheduled to CI, educational level has a significant effect. Additionally, sex, physical inactivity, hypertension, and psychological traits of social inhibition and depression may also influence cognitive status. Long-term studies with more participants would enable us better understand the effects different risk factors on cognitive status.

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Section: Discussionmentioning

confidence: 99%

The effect of risk factors on cognition in adult cochlear implant candidates with severe to profound hearing loss

et al. 2022

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“…However, in an in vivo study, IL-6 overexpression induced the reduction in neuroinflammation at the Aβ level rather than aggravating the pathology of Aβ plaques [ 73 ]. Irina Belaya et al reported regular exercise can modulate iron homeostasis in WT mice and in a mouse model of AD via the IL-6/STAT3/JAK1 pathway [ 74 ], indicating that M2 type microglia are mainly activated, which enhances the phagocytic function of Aβ [ 73 ]. The combination of IL-18 and its receptor complex can activate c-Jun N-terminal kinase (JNK) and MAPK-p38, thereby activating endogenous and exogenous pro-apoptotic signaling pathways [ 75 ].…”

Section: Il-37 In Cns Diseasesmentioning

confidence: 99%

Recent Advances in Progresses and Prospects of IL-37 in Central Nervous System Diseases

Yan

et al. 2022

Brain Sciences

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Interleukin-37 (IL-37) is an effective anti-inflammatory factor and acts through intracellular and extracellular pathways, inhibiting the effects of other inflammatory cytokines, such as IL-1β, IL-6, and tumor necrosis factor-α (TNF-α), thereby exerting powerful anti-inflammatory effects. In numerous recent studies, the anti-inflammatory effects of IL-37 have been described in many autoimmune diseases, colitis, and tumors. However, the current research on IL-37 in the field of the central nervous system (CNS) is not only less, but mainly for clinical research and little discussion of the mechanism. In this review, the role of IL-37and its associated inflammatory factors in common CNS diseases are summarized, and their therapeutic potential in CNS diseases identified.

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“…Iron-dysregulation homeostasis is well-known and evident in AD [2], but there is still little known about the influence of physical exercise on iron metabolism in the brain and peripheral nervous system, as well as the mechanisms responsible for exercise-induced iron regulation in AD. In the animal model, long-term voluntary running induced the redistribution of iron, which had an impact in altered iron metabolism and trafficking in the brain, and increased iron content in skeletal muscle [46]. Belaya et al found that exercise reduced levels of cortical hepcidin, a key regulator of iron homeostasis, and reduced the levels of interleukin-6 (IL-6) in cortex and plasma [46].…”

Section: Introductionmentioning

confidence: 99%

“…In the animal model, long-term voluntary running induced the redistribution of iron, which had an impact in altered iron metabolism and trafficking in the brain, and increased iron content in skeletal muscle [46]. Belaya et al found that exercise reduced levels of cortical hepcidin, a key regulator of iron homeostasis, and reduced the levels of interleukin-6 (IL-6) in cortex and plasma [46]. The authors stated that regular exercise can induce a reduction in hepcidin in the brain, possibly via the IL-6/STAT3/JAK1 pathway [46].…”

Section: Introductionmentioning

confidence: 99%

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Cognitive and Physical Intervention in Metals’ Dysfunction and Neurodegeneration

2022

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Metals—especially iron, copper and manganese—are important elements of brain functions and development. Metal-dysregulation homeostasis is associated with brain-structure damage to the motor, cognitive and emotional systems, and leads to neurodegenerative processes. There is more and more evidence that specialized cognitive and motor exercises can enhance brain function and attenuate neurodegeneration in mechanisms, such as improving neuroplasticity by altering the synaptic structure and function in many brain regions. Psychological and physical methods of rehabilitation are now becoming increasingly important, as pharmacological treatments for movement, cognitive and emotional symptoms are limited. The present study describes physical and cognitive rehabilitation methods of patients associated with metal-induced neurotoxicity such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease and Wilson’s disease. In our review, we describe physical (e.g., virtual-reality environments, robotic-assists training) and psychological (cognitive training, cognitive stimulation, neuropsychological rehabilitation and cognitive-behavioral and mindfulness-based therapies) methods, significantly improving the quality of life and independence of patients associated with storage diseases. Storage diseases are a diverse group of hereditary metabolic defects characterized by the abnormal cumulation of storage material in cells. This topic is being addressed due to the fact that rehabilitation plays a vital role in the treatment of neurodegenerative diseases. Unfortunately so far there are no specific guidelines concerning physiotherapy in neurodegenerative disorders, especially in regards to duration of exercise, type of exercise and intensity, as well as frequency of exercise. This is in part due to the variety of symptoms of these diseases and the various levels of disease progression. This further proves the need for more research to be carried out on the role of exercise in neurodegenerative disorder treatment.

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Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease

Cited by 14 publications

References 81 publications

The effect of risk factors on cognition in adult cochlear implant candidates with severe to profound hearing loss

The effect of risk factors on cognition in adult cochlear implant candidates with severe to profound hearing loss

Recent Advances in Progresses and Prospects of IL-37 in Central Nervous System Diseases

Cognitive and Physical Intervention in Metals’ Dysfunction and Neurodegeneration

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