Regular exercise, alcohol consumption, and smoking interact with the polygenetic risk scores involved in insulin sensitivity and secretion for the risk of concurrent hyperglycemia, hypertension, and dyslipidemia

Zhou, Junyu; Park, Sunmin

doi:10.1016/j.nut.2021.111422

Cited by 1 publication

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“…Alcohol consumption is a well-known determinant of serum lipids levels [ 17 , 18 , 19 ]. Moderate alcohol consumption appears to raise levels of high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) while lowering levels of low-density lipoprotein cholesterol (LDL-C), whereas heavy alcohol consumption has an unfavorable effect on serum lipids and lipoproteins [ 20 ]. It is reasonable to assume that the manner of alcohol consumption could contribute to the development of obesity, and further changes to lipids parameters causing dyslipidemia.…”

Section: Introductionmentioning

confidence: 99%

Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile

Gao

et al. 2021

IJERPH

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Background: Both obesity and alcohol consumption are strongly associated with dyslipidemia; however, it remains unclear whether their joint effect on lipid profiles is through mediation, interaction, or a combination of the two. Methods: In total, 9849 subjects were selected from the 2009 panel of China Health and Nutrition Survey (CHNS). A four-way decomposition method was used to validate the pathways of drinking and body mass index (BMI) on lipids (total cholesterol, TC; triglyceride, TG; low-density lipoprotein cholesterol, LDL-C; high-density lipoprotein cholesterol, HDL-C; apolipoprotein A, APO-A; and apolipoprotein B, APO-B). Results: According to four-way decomposition, the total effects of drinking on lipids were found to be statistically significant, except for LDL-C. The components due to reference interaction were 0.63, 0.48, 0.60, −0.39, −0.30, and 0.20 for TC, TG, LDL-C, HDL-C, APO-A and APO-B, respectively (p < 0.05 for all). The effect size of pure indirect effect and mediated interaction were 0.001~0.006 (p > 0.05 for all). Further, linear regression models were used to examine the effect of BMI on lipid profiles in drinkers and non-drinkers. The associations of BMI and lipids were higher in all drinkers than in non-drinkers (0.069 versus 0.048 for TC, 0.079 versus 0.059 for TG, 0.057 versus 0.037 for LDL-C, −0.045 versus −0.029 for HDL-C, −0.024 versus −0.011 for APO-A and 0.026 versus 0.019 for APO-B, p interaction <0.05 for all). Conclusions: The joint effect of alcohol consumption and obesity on lipid profiles is through interaction rather than mediation. Alcohol consumption amplifies the harmful effect of BMI on lipid profiles. Greater attention should be paid to lipid health and cardiovascular risk in obese individuals regarding alcohol consumption. For obese individuals, we do not recommend alcohol consumption.

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Section: Introductionmentioning

confidence: 99%

Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile

Gao

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

Regular exercise, alcohol consumption, and smoking interact with the polygenetic risk scores involved in insulin sensitivity and secretion for the risk of concurrent hyperglycemia, hypertension, and dyslipidemia

Cited by 1 publication

References 44 publications

Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile

Four-Way Decomposition of Effect of Alcohol Consumption and Body Mass Index on Lipid Profile

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