Regular automated erythrocytapheresis in sickle cell patients

Safety, tolerability, and outcomes of regular automated red cell exchange transfusion in the management of sickle cell disease

“…Iron overload is a serious complication of chronic transfusions associated with significant morbidity and mortality. Previous studies have suggested that ARCET is not associated with significant iron accumulation [12][13][14][15][16]. All these studies reported on SF results and even though suggestive, the results were not always consistent.…”

Erythrocytapheresis for chronic transfusion therapy in sickle cell disease: survey of current practices and review of the literature

“…1,4,5,7,13,18,20,22 The remaining four studies reported that new, clinically significant antibodies formed in 7%, 9%, 10%, and 23% of 43, 32, 20, and 13 patients, respectively. 15,17,23,24 Collectively, 11 of 192 patients (5.7%) in the 11 reports became immunized to RBC antigens during aRBX. Most of the institutions transfused RBCs that were phenotypically matched for CE and Kell, and some institutions reported more extensive phenotypic matching.…”

AutomatedRBCexchange compared to manual exchange transfusion for children with sickle cell disease is cost‐effective and reduces iron overload

“…19,20 However, chronic transfusion remains the gold standard therapy for primary and secondary stroke prevention despite promising results with hydroxyurea. [21][22][23][24][25] Chronic transfusion is also indicated for 1) patients with recurrent VOC or ACS despite optimal hydroxyurea treatment, [26][27][28] and 2) specific organ dysfunction. 26 Exchange transfusion is better than top-up transfusion, as it prevents iron overload 29,30 and maintains hemoglobin S (HbS) level within target values.…”