Regular Aerobic Exercise Prevents and Restores Age-Related Declines in Endothelium-Dependent Vasodilation in Healthy Men

DeSouza, Christopher A.; Shapiro, Linda F.; Clevenger, Christopher M.; Dinenno, Frank A.; Monahan, Kevin D.; Tanaka, H; Seals, Douglas R.

doi:10.1097/00008483-200103000-00010

Cited by 141 publications

(229 citation statements)

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“…In this study, we decided to place the cuff on the upper arm because in this condition the reactive hyperaemia is able to elicit a more evident change in the diameter in comparison with that produced when the cuff is placed on the forearm (Corretti et al, 2002). It has already been demonstrated that physical training improves FMD of the brachial artery in young (Clarkson et al, 1999) as well as old men (Rywik et al, 1999;DeSouza et al, 2000) and even in patients with diabetes (Stewart, 2002) or metabolic syndrome (Lavrencic et al, 2000). Despite the fact that the young subjects included in the present study were already well trained at baseline and had, therefore, normal endothelial function, the preischaemic brachial artery diameter significantly increased at the end of the NP diet (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Many of these interventions were shown to improve the outcome of the diseases, favourably affecting the endothelium-dependent arterial function, echographically determined as flow-mediated vasodilatation at the brachial artery level (Irace et al, 2001;Lind, 2001). Physical exercise was shown to not only improve endothelial dysfunction in old subjects and in patients affected by different metabolic disorders (Gilligan et al, 1994;Rywik et al, 1999;DeSouza et al, 2000;Stewart, 2002) but also to enhance endothelial function in young healthy men (Clarkson et al, 1999). Also dietary interventions, regarding in particular the lipid component of the diet, were detected to induce an improvement in the endothelial function.…”

Section: Introductionmentioning

confidence: 99%

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Effects of different dietary protein intakes on body composition and vascular reactivity

et al. 2005

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Objective: To assess the effects of a diet rich in protein of animal origin in comparison to one with a protein intake of about 15% of the total daily calories on body composition and arterial function. Design: Randomized prospective study with parallel groups. Body weight (BW), blood pressure (BP), main parameters of carbohydrate and lipid metabolism, body mass composition by bioelectrical impedance analysis, forearm blood flow at rest and in the postischaemic phase by strain gauge plethysmography and flow-mediated dilation of the brachial artery by echography were measured at baseline and after 6 months of the dietary intervention. Subjects: In total, 15 clinically healthy male volunteers, regularly performing a mixed training three times weekly for 90 min. Intervention: The participants were randomly prescribed a diet with high (1.9 g/kg BW) or normal (1.3 g/kg BW) protein content. Statistical analysis: Differences between means were evaluated by the t-tests for paired or unpaired data and by one way analysis of variance. The strength of correlation between variables was investigated by bivariate Pearson correlation. Results: Serum cholesterol significantly decreased with both diets in comparison to baseline values, whereas BW was slightly but significantly reduced only by the high-protein (HP) diet. No change was detected in BP and the other metabolic parameters. Body mass composition was not significantly modified by either diet. On the other hand, postischaemic flow-mediated dilation of the brachial artery was enhanced by the sole normal protein (NP) diet, whereas no change in the forearm blood flow, both at rest and in the postischaemic phase, was detected. Conclusions: These preliminary results indicate that HP diet was found to be not useful in increasing the muscle mass in comparison to a NP intake. In contrast to this, the latter diet seems to enhance the endothelial function of the arterial vessels with a more pronounced dilatation of the lumen in response to the increase in blood flow.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of different dietary protein intakes on body composition and vascular reactivity

et al. 2005

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“…81,82 ET also protects against oxidative stress, leading to lower nitric oxide scavenging by oxidation and higher nitric oxide bioavailability which have anti-hypertensive effects. 83 ET-induced improvements in managing oxidative stress help lower systemic inflammatory markers in physically active people with CHD. Ranković et al reported that men and women participating in a 6-week ET program (a combination of center-based followed by home-based delivery) had C-reactive protein levels that declined by 23.7% (p…”

Section: Effects Of Et On CV Physiologymentioning

confidence: 99%

Impact of cardiac rehabilitation and exercise training programs in coronary heart disease

Kachur

Chongthammakun

Lavie

et al. 2017

Progress in Cardiovascular Diseases

128

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“…These include individuals with chronic heart failure [7,8] coronary artery occlusion [9], hypertension [10,11], ageing [12], impaired glucose tolerance [13], type 1 diabetes [14] and type 2 diabetes [15], thereby supporting a role for regular exercise as a useful therapy for the reversal of endothelial dysfunction and the subsequent reduction in cardiovascular risk in these populations.…”

Section: Introductionmentioning

confidence: 99%

Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus

et al. 2006

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Aims/hypothesis Adults with type 2 diabetes mellitus have impaired microvascular function. It has been hypothesised that microvascular function may be restored through regular exercise. The aim of this study was to investigate whether 6 months of regular aerobic exercise would improve microvascular function in adults with type 2 diabetes. Materials and methods Fifty-nine patients with type 2 diabetes (32 males, age 62.9±7.6 years, HbA 1c 6.8±0.9%) were randomised to either a 6-month aerobic exercise programme (30 min, three times a week, 70-80% of maximal heart rate) or a 'standard care' control group. Before and after the intervention period, microvascular function was assessed as the maximum skin hyperaemia to local heating and endothelial and non-endothelial responsiveness following the iontophoretic application of acetylcholine and sodium nitroprusside. Maximal oxygen uptake, as an index of aerobic fitness, was assessed using a maximal exercise test.

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Regular Aerobic Exercise Prevents and Restores Age-Related Declines in Endothelium-Dependent Vasodilation in Healthy Men

Cited by 141 publications

References 0 publications

Effects of different dietary protein intakes on body composition and vascular reactivity

Effects of different dietary protein intakes on body composition and vascular reactivity

Impact of cardiac rehabilitation and exercise training programs in coronary heart disease

Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus

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