Regucalcin, a novel regulatory protein implicated in obesity and diabetes

Yamaguchi, Masayoshi

doi:10.15761/imm.1000102

Cited by 2 publications

(1 citation statement)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result was not confirmed in the current experiments, where the RGN level was elevated in mice fed the 14:1 diet in comparison to the STD group (a low n–3-PUFA diet) ( p < 0.01). RGN overexpression was shown to induce hepatic insulin resistance and hyperlipidemia in rats [ 87 ]. Yamaguchi et al showed increased serum RGN levels, whereas liver mRNA levels decreased after carbon tetrachloride administration, suggesting a role of this protein in cellular response in chronic liver damage [ 88 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Three-Month Administration of High-Saturated Fat Diet and High-Polyunsaturated Fat Diets with Different Linoleic Acid (LA, C18:2n–6) to α-Linolenic Acid (ALA, C18:3n–3) Ratio on the Mouse Liver Proteome

et al. 2021

View full text Add to dashboard Cite

The aim of the study was to evaluate the effect of different types of high-fat diets (HFDs) on the proteomic profile of mouse liver. The analysis included four dietary groups of mice fed a standard diet (STD group), a high-fat diet rich in SFAs (SFA group), and high-fat diets dominated by PUFAs with linoleic acid (LA, C18:2n–6) to α-linolenic acid (ALA, C18:3n–3) ratios of 14:1 (14:1 group) and 5:1 (5:1 group). After three months of diets, liver proteins were resolved by two-dimensional gel electrophoresis (2DE) using 17 cm non-linear 3–10 pH gradient strips. Protein spots with different expression were identified by MALDI-TOF/TOF. The expression of 13 liver proteins was changed in the SFA group compared to the STD group (↓: ALB, APOA1, IVD, MAT1A, OAT and PHB; ↑: ALDH1L1, UniProtKB—Q91V76, GALK1, GPD1, HMGCS2, KHK and TKFC). Eleven proteins with altered expression were recorded in the 14:1 group compared to the SFA group (↓: ARG1, FTL1, GPD1, HGD, HMGCS2 and MAT1A; ↑: APOA1, CA3, GLO1, HDHD3 and IVD). The expression of 11 proteins was altered in the 5:1 group compared to the SFA group (↓: ATP5F1B, FTL1, GALK1, HGD, HSPA9, HSPD1, PC and TKFC; ↑: ACAT2, CA3 and GSTP1). High-PUFA diets significantly affected the expression of proteins involved in, e.g., carbohydrate metabolism, and had varying effects on plasma total cholesterol and glucose levels. The outcomes of this study revealed crucial liver proteins affected by different high-fat diets.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Three-Month Administration of High-Saturated Fat Diet and High-Polyunsaturated Fat Diets with Different Linoleic Acid (LA, C18:2n–6) to α-Linolenic Acid (ALA, C18:3n–3) Ratio on the Mouse Liver Proteome

et al. 2021

View full text Add to dashboard Cite

show abstract

Fermented extract of mealworm (Tenebrio molitor larvae) as a dietary protein source modulates hepatic proteomic profiles in C57BLKS/J-db/db mice

Turkyilmaz

Lee

2023

JIFF

View full text Add to dashboard Cite

This study hypothesised that fermented mealworm extract (TMP) with higher amino acid contents than nonfermented extract can be used as a dietary protein source for type 2 diabetes mellitus, and compared its effects with casein (CA) using C57BLKS/J-db/db mice. TMP marginally lowered serum insulin and leptin levels and hepatic triglyceride, and lipid droplets compared with CA group. Proteomic analysis showed that 14 proteins (H4C1, CYB5A, ANXA5, RGN, 40S ribosomal protein, Atp2, PDI, GRP78, RDX, GCH1, LDHA, GNMT, ACAA2, and UROC1) were up-regulated and 8 proteins (UQCRC1, Txndc5, SBP2, HSPA8, PHB, TF, PC, and PK) were down-regulated in the CA group compared to the normal mice. However, TMP significantly down-regulated ANXA5, RGN, Atp2, PDI, RDX, LDHA, ACAA2, and UROC1, and up-regulated UQCRC1, PHB, TF, and PK. These proteins are related to glycolysis, lactate production, fatty acid β-oxidation, oxidative stress, and endoplasmic reticulum stress. These results suggest that TMP is a potential protein source that can replace CA in type 2 diabetes.

show abstract

Regucalcin, a novel regulatory protein implicated in obesity and diabetes

Cited by 2 publications

References 83 publications

Effects of Three-Month Administration of High-Saturated Fat Diet and High-Polyunsaturated Fat Diets with Different Linoleic Acid (LA, C18:2n–6) to α-Linolenic Acid (ALA, C18:3n–3) Ratio on the Mouse Liver Proteome

Effects of Three-Month Administration of High-Saturated Fat Diet and High-Polyunsaturated Fat Diets with Different Linoleic Acid (LA, C18:2n–6) to α-Linolenic Acid (ALA, C18:3n–3) Ratio on the Mouse Liver Proteome

Fermented extract of mealworm (Tenebrio molitor larvae) as a dietary protein source modulates hepatic proteomic profiles in C57BLKS/J-db/db mice

Contact Info

Product

Resources

About