Regressive melanoma in a female patient: A case report

Şandru, Florica; Draghici, Carmen‐Cristina; Predescu, Teodora; Constantin, Maria Magdalena; Petca, R.; Constantin, Traian; Petca, Aida; Dumitrașcu, Mihai Cristian

doi:10.3892/etm.2020.8675

Cited by 9 publications

(6 citation statements)

References 22 publications

(15 reference statements)

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“…Other tumorigenic risks have been reported in CNC including melanoma; yet currently it is considered incidental, but a clear histological and immunohistochemically differentiation from melanotic schwannoma is required (71,72). Uveal melanoma has also been reported in cases with CNC, but the association is not typical (73).…”

Section: Discussionmentioning

confidence: 99%

Dermatological and endocrine elements in Carney complex (Review)

et al. 2021

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Carney complex (CΝC) is a very rare, autosomal dominant, hereditary syndrome. Seventy percent of individuals with CNC have germline inactivating or deleting mutations of the CNC1 gene [currently known as protein kinase cAMP-dependent type I regulatory subunit α (PRKAR1A), located at the 17q22-24 chromosome level], with 30% of cases presenting with phosphodiesterase gene mutations. A member of the lentiginosis family, dermatological features include: skin pigmentation, cutaneous/mucosal myxomas, usually diagnosed by the age of 20 years (neonatal presentation is exceptional, requiring a meticulous differential diagnosis). Melanocyte-derived tumors such as epithelioid blue nevi (with different levels of pigmentation) and pigmented epithelioid melanocytoma (previously 'animal-type melanoma') are often found. Myxomas, mesenchymal tumors with mostly a benign pattern, may be recurrent. Primary cutaneous melanotic schwannoma are atypical, while non-skin sites are frequent. Corticotropinomas or somatotropinomas are part of the hereditary syndrome-related pituitary adenomas (representing 5% of all). Primary pigmented nodular adrenocortical disease involves bilateral cortical hyperplasia causing Cushing syndrome (CS) at an earlier age than non-CNC cases; osteoporotic fractures seem more prevalent compare to CS of other etiologies. Typically benign, a few cases of adrenocortical carcinoma have been identified. A total of 5% of familial non-medullary thyroid cancer is syndromic, also including CNC. CNC-related thyroid frame includes: hyperthyroidism, follicular hyperplasia/adenomas, follicular carcinoma (usually aggressive, bilateral or multifocal). Large cell calcifying Sertoli cell tumors of the testes have malignant behavior in adults; in children these may induce precocious puberty. Two particular mammary tumors are found: myxoid fibroadenomas and breast myxomatosis. Cutaneous/subcutaneous lesions, pigmented or not, or any focal swelling of non-identified cause needs careful examination, since dermatological elements are among the earliest and most discernable by which to detect lesions in CNC, a systemic condition with multi-level endocrine involvement.

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Section: Discussionmentioning

confidence: 99%

Dermatological and endocrine elements in Carney complex (Review)

et al. 2021

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“…Melanoma arises from the deterioration of melanocytes located in the basement of the epidermis (100). It is the most aggressive form of skin cancer (101,102). Pyruvate kinase (PK) participates in the transformation of phosphoenolpyruvate to pyruvate and is a rate-limiting enzyme in the last step of the glycolysis process (103,104).…”

Section: Melanomamentioning

confidence: 99%

Crucial Roles of miR-625 in Human Cancer

et al. 2022

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Genetic and epigenetic characteristics are core factors of cancer. MicroRNAs (miRNAs) are small non-coding RNAs which regulate gene expression at the post-transcriptional level via binding to corresponding mRNAs. Recently, increasing evidence has proven that miRNAs regulate the occurrence and development of human cancer. Here, we mainly review the abnormal expression of miR-625 in a variety of cancers. In summarizing the role and potential molecular mechanisms of miR-625 in various tumors in detail, we reveal that miR-625 is involved in a variety of biological processes, such as cell proliferation, invasion, migration, apoptosis, cell cycle regulation, and drug resistance. In addition, we discuss the lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA networks and briefly explain the specific mechanisms of competing endogenous RNAs. In conclusion, we reveal the potential value of miR-625 in cancer diagnosis, treatment, and prognosis and hope to provide new ideas for the clinical application of miR-625.

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“…Many other reports [113][114][115][116] have described cases of primary melanoma of the penis/male urethra. Instead, in 2020, Naktra et al [100] presented a curious case of primary melanoma of the female urethra with neuroendocrine differentiation, in a 62-yearold woman with urinary obstruction symptoms.…”

Section: Urethra and Penismentioning

confidence: 99%

Urological Melanoma: A Comprehensive Review of a Rare Subclass of Mucosal Melanoma with Emphasis on Differential Diagnosis and Therapeutic Approaches

Cazzato

Colagrande

Cimmino

et al. 2021

Cancers

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Melanoma is reported as the 19th most common cancer worldwide, with estimated age-standardized incidence rates of 2.8–3.1 per 100,000. Although the origin is most frequently cutaneous, mucosal melanoma has been described several times in literature, and despite its rarity (only 1% of all melanomas), increasing attention is being paid to this disease form. Within this subgroup, melanomas of the uropoetic apparatus are a rarity among rarities. Indeed, less than 50 cases of primary melanoma originating from the urinary bladder have been described, and even less originating from the kidney, renal pelvis and urethra. In this work, we present a detailed review of the literature related to this subclass of mucosal melanoma, delve into the biological landscape of this neoplasm and discuss current approaches, future perspectives and potential therapeutic approaches.

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Regressive melanoma in a female patient: A case report

Cited by 9 publications

References 22 publications

Dermatological and endocrine elements in Carney complex (Review)

Dermatological and endocrine elements in Carney complex (Review)

Crucial Roles of miR-625 in Human Cancer

Urological Melanoma: A Comprehensive Review of a Rare Subclass of Mucosal Melanoma with Emphasis on Differential Diagnosis and Therapeutic Approaches

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