Regressive Changes in the Superficial Layer of Human Articular Cartilage

Meachim, G.; Ghadially, F. N.; Collins, Douglas H.

doi:10.1136/ard.24.1.23

Cited by 75 publications

(41 citation statements)

References 7 publications

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“…In some cases among the mitochondria of a usual appearance there appear also small amounts of mitochondria with a strikingly light matrix and slightly damaged cristae. They are probably disintegrating mitochondria as was also stated by Kaplan and Meyer (1959), Meachim et al (1965), Weiss and Mirrow (1972), Ghadially et al (1970), Mitchell and Shepard (1970), Dearden et al (1974), Gritzka et al (1974), Refior (1974), Rother and Redel (1975), Hanaoka (1976), Podrushniak and Cerkasov (1976), Silberger et al (1976), and others especially on the basis of investigations of these organelles in ageing cartilage and initial forms of arthroses. Ri b 0 so m es in the cytoplasm of chondrocytes of the superficial layer are mostly bound to membrane of the granular endoplasmic reticulum.…”

Section: B) Cytoplasmmentioning

confidence: 73%

Submicroscopic Structure of the Human Joint Cartilage

Horký¹

1980

Acta Vet. Brno

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H 0 r k yD.: Submicroscopic Structure of the Human Joint Cartilage. Acta vet. Brno, 49, 1980: 145-176.Using a transmission and scanning electron microscope the joint cartilage was studied in 43 persons of the age from 5 to 75 years. As far as possible the present study gives a finished survey of the ultrastructure of chondrocytes of the superficial, middle and deep layers of the articular cartilage, arrangement of the intercellular substance; presented are basic data on the formation of the surface of the cartilage with regard to the age of the object. Special attention is given to cartilage intercellular substance which -from the point of view of electron microscopy -has been studied only little. The components of intercellular substance are arranged in such a way that we can distinguish the specialized areas near the chondrocytes as the pericellular matrix on the one hand, and the other intercellular substance, the intercellular matrix, on the other. The surface of the cartilage is covered with a specialized layer designated as lamina splendens. Results of the study proper are confronted with published data not only with regard to human joint cartilage but data on these structures have been studied also in lower mammals as much knowledge holds generally true for this type of tissue. The study summarizes the known facts about joint cartilage and provides a necessary basis for judging the degrees of changes occurring during some of their injuries. Ultrastructure, hip joint cartilage, chondrocytes, intercellular matrix, SEM.A number of authors dealt with the description of submicroscopic structure of joint cartilage; principal studies dealing with human cartilage were published by Zelander (1959), Godman et al. (1960), Fawcett (1966a), Meachim (1967), Stockwell (1967a), Silberger (1968, Weiss et al. (1968). Brower and Hsu (1969), Roy (1969), Meachim (1969), Meachim and Roy (1969), Hirohata and Morimoto (1971), Stockwell andMeachim (1973), Serafini-Fracassini and Smith (1974), and others. The present study gives the most possible finished survey about the ultrastructure of both the chondrocytes of the joint cartilage and the intercellular substance; given are also basic data on the formation of its surface in dependence on the age of the object. Results of our study are confronted with published data not only with regard to human joint cartilage but also to data on lower mammals as much knowledge holds generally true for this type of tissue. This fact has been proved in studies published by Barnett et al.

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Section: B) Cytoplasmmentioning

confidence: 73%

Submicroscopic Structure of the Human Joint Cartilage

Horký¹

1980

Acta Vet. Brno

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“…To the Editor: Recent controversy between Dr. Fassbender (1) and Dr. Shiozawa (2,3) regarding the cell composition and nature of "synovial" pannus in rheumatoid arthritis prompted us to report our own observations and offer an alternative interpretation of the origin and nature of pannus tissue.…”

Section: The Mechanism Of Cartilage Destruction In Rheumatoid Arthritmentioning

confidence: 99%

“…Collagen fibers seem to resist degradation, thus the tissue appears loose and fibrous with a small number of cells which are mainly gathered at the cartilage-pannus interface. This stage of cartilage self-resorption may correspond to the paucicellular noninvasive fibrous pannus described by Shiozawa et al (2,3) and to the pannus containing tumor-like immature mesenchymal cells mentioned by Fassbender (1). The tumor-like immature mesenchymal cells may represent actively resorbing chondrocytes still in contact with the hyaline matrix.…”

Section: The Mechanism Of Cartilage Destruction In Rheumatoid Arthritmentioning

confidence: 99%

The mechanism of cartilage destruction in rheumatoid arthritis

Mitrović¹,

Fassbender²,

Shiozawa³

1985

Arthritis & Rheumatism

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“…Histologic staining of OA tissue has demonstrated that the PG loss is nonuniform, with depth into the tissue, beginning at the articular surface and proceeding progressively inward [116,161]. The PGs which remain in the OA cartilage may have a number of qualitative abnormalities, including decreased aggregate formation, decreased size of both PG aggregates and aggrecan subunits, and increased extractability from the tissue.…”

Section: Biochemical Composition Changesmentioning

confidence: 99%