Regression of Warts an Immunological Study

Pyrhönen, Seppo; Johansson, Eija

doi:10.1016/s0140-6736(75)91880-2

Cited by 81 publications

(36 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antibodies were found in three of the seven regressors. Pyrhonen and Johansson [10] claim that a type III immune reaction occurs when fast regression of warts is observed in the presence of antibody.…”

Section: Discussionmentioning

confidence: 99%

Treatment of the Common Wart by Induced Allergic Inflammation

Eriksen¹

1980

Dermatology

View full text Add to dashboard Cite

In an uncontrolled investigation 63 selected patients with verrucae vulgares were sensitized with DNCB (1-chloro-2,4-dinitrobenzene) with subsequent regular painting of the warts with DNCB. Only 86% of these patients could be sensitized, in contrast to 96% in a normal population. 20 patients had to be excluded from the material on account of defaulting or defective sensitization. In the remainder of the patients allergic type IV inflammation developed around the painted warts and 1 patient developed an urticarial type I reaction around the warts and on the body. In the patients with multiple warts, 80% (24/30) were cured. This corresponds to the percentage cure in patients with solitary warts. Complement-binding wart virus antibodies were present in 15% of the patients prior to the treatment and in 43% after the conclusion of treatment. This investigation provides a new method of treatment of verrucae vulgares and suggests that regression in the warts is immunologically conditioned. On account of the risk of allergic side effects, the method should be carried out in special departments only.

show abstract

Section: Discussionmentioning

confidence: 99%

Treatment of the Common Wart by Induced Allergic Inflammation

Eriksen¹

1980

Dermatology

View full text Add to dashboard Cite

show abstract

“…The place of hu moral immunity is less well understood, but may also play a role in wart regression. Wart virus specific IgG and IgM antibodies have been shown to be present in much higher quantities in patients with regressing warts than in patients with non-regressing warts [8,9]. As well, the occurrence of complement-fixating antibodies of the IgG type was found to be associated with rapid regres sion of warts [8].…”

Section: Commentmentioning

confidence: 97%

Severe Condylomata acuminata in a Renal Transplant Recipient

Landsberg¹,

Bear²

1986

Am J Nephrol

View full text Add to dashboard Cite

“…They were the first to detect measurable antibodies against pooled, homogenized human wart tissue, detected in 92% of women and 75% of men aged between 15 and 19 years [13]. Their observation on a roughly inverse correlation between the number and duration of skin warts and the antibody levels was also important [13,14]. While studying patients with systemic lupus erythematosus, who showed HPV antibodies less frequently than their immunocompetent counterparts, the authors concluded that this lack of humoral response to HPV might explain the increased frequency of warts in these patients [15].…”

Section: What Was Known About Pvs and Human Disease Before 1976/1977?mentioning

confidence: 99%

“…One cannot avoid an impression, however, that they did this unintentionally, because none of the preceding virological (molecular) studies from the past decades (Table 1), nor the more recent ones by zur Hausen [17,18,19] and Pyrhönen [13,14], are included in their references or discussed to any extent. …”

Section: What Was Known About Pvs and Human Disease Before 1976/1977?mentioning

confidence: 99%

Two Landmark Studies Published in 1976/1977 Paved the Way for the Recognition of Human Papillomavirus as the Major Cause of the Global Cancer Burden

Syrjänen¹

2017

Acta Cytologica

View full text Add to dashboard Cite

Two groundbreaking reports were published in Acta Cytologica at the transition of 1976 to 1977. One appeared in the last issue of 1976 [Meisels and Fortin: Acta Cytol 1976;20:505-509] and the other in the first issue of 1977 [Purola and Savia: Acta Cytol 1977;21:26-31]. Today, 40 years later, it is not an overstatement to conclude that these are the two most influential studies ever published in this journal. Two reports with a similar content being published so close together (in the same journal) raised the question “Which of the two reports was truly submitted first?” In this commentary, this enigma is clarified beyond reasonable doubt, based on the well-considered testimonial of Prof. Leopold G. Koss, the reviewer of one of the two papers. To fully appreciate the significance of the novel discovery made in these two reports, it is essential to align them in the right context, both retrospectively and prospectively. This commentary will assist the reader by summarizing the existing knowledge on human papillomavirus (HPV) before these two milestone papers appeared, and describe the incredibly rapid progress that they evoked during the subsequent decades, which made HPV the single most important human tumor virus. As the final proof of virus-cancer causality, prophylactic HPV vaccines have been effective in preventing (a) virus transmission and HPV infection, (b) benign HPV-induced tumors (genital warts), and (c) cervical intraepithelial neoplasia (CIN). Formal evidence of the prevention of cervical cancer by these HPV vaccines still awaits confirmation, and the same applies to the eventual prevention of human cancers at other anatomic sites, part of the global burden of oncogenic HPVs.

show abstract

Regression of Warts an Immunological Study

Cited by 81 publications

References 14 publications

Treatment of the Common Wart by Induced Allergic Inflammation

Treatment of the Common Wart by Induced Allergic Inflammation

Severe Condylomata acuminata in a Renal Transplant Recipient

Two Landmark Studies Published in 1976/1977 Paved the Way for the Recognition of Human Papillomavirus as the Major Cause of the Global Cancer Burden

Contact Info

Product

Resources

About