Regression of rectal MALT lymphoma after antibiotic treatment in a patient negative for Helicobacter pylori

Ohara, Eiji; Kitadai, Yasuhiko; Onoyama, Mieko; Ohnishi, Mayu; Shinagawa, Kei; Oka, Shiro; Yoshida, Shigeto; Tanaka, Shinji; Sakamoto, Naoyai; Yasui, Wataru; Shimamoto, Fumio; Chayama, Kazuaki

doi:10.1007/s12328-011-0270-5

Cited by 9 publications

(5 citation statements)

References 16 publications

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“…Several case reports have documented the efficacy of H. pylori eradication therapy for rectal MALT lymphoma . However, improvements with eradication are also observed in H. pylori ‐negative cases . Moreover, non‐ H. pylori bacterial species susceptible to antibiotics may be involved in lesion formation.…”

Section: Indicationsmentioning

confidence: 99%

Guidelines for the management of Helicobacter pylori infection in Japan: 2016 Revised Edition

et al. 2019

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Background Since “Helicobacter pylori (H. pylori) infection” was set as the indication in the Japanese Society for Helicobacter Research (JSHR) Guidelines 2009, eradication treatment for H. pylori gastritis is covered under insurance since 2013 in Japan, and the number of H. pylori eradication has rapidly increased. Under such circumstances, JSHR has made the third revision to the “Guidelines for diagnosis and treatment of H. pylori infection” for the first time in 7 years. Methods The Guideline Committee held 10 meetings. Articles published between the establishment of the 2009 Guidelines and March 2016 were reviewed and classified according to the evidence level; the statements were revised on the basis of this review. After inviting public comments, the revised statements were finalized using the Delphi method. Results There was no change in the basic policy that H. pylori infectious disease is an indication for eradication. Other diseases presumed to be associated with H. pylori infection were added as indications. Serum pepsinogen level, endoscopic examination, and X‐ray examination were added to the diagnostic methods. The effects of 1‐week triple therapy consisting of potassium‐competitive acid blocker (P‐CAB), amoxicillin, and clarithromycin have improved, and high eradication rates can also be expected with proton pump inhibitors (PPI) or P‐CAB combined with amoxicillin and metronidazole. If the susceptibility test is not performed, the triple PPI or P‐CAB/amoxicillin/metronidazole therapy should be chosen, because the PPI/amoxicillin/metronidazole combination demonstrated a significantly higher eradication rate than PPI/amoxicillin/clarithromycin. In the proposal for gastric cancer prevention, we divided gastric cancer prevention measures by age from adolescent to elderly, who are at an increased gastric cancer risk, and presented measures for gastric cancer prevention primarily based on H. pylori eradication. Conclusion We expect the revised guidelines to facilitate appropriate interventions for patients with H. pylori infection and accomplish its eradication and prevention of gastric cancer.

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Section: Indicationsmentioning

confidence: 99%

Guidelines for the management of Helicobacter pylori infection in Japan: 2016 Revised Edition

et al. 2019

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“… 55 , 79 , 95 - 97 The presence of t(11;18) translocation has been linked to significant resistance to H pyloriE . 46 , 55 , 60 , 69 , 96 , 98 No significant differences were observed in relapse rates between H pylori -positive and H pylori- negative ENMZL post- H pyloriE treatment. 99 …”

Section: Discussion and Literature Reviewmentioning

confidence: 88%

“… 42 Of these, only 19% of 44 tested cases were H pylori -positive. Our literature review from 1999 to 2017 identified 8 cases of H pylori -negative rectal ENMZL, 43 - 48 and 3 cases of H pylori -negative colonic ENMZL. 49 Single case reports of H pylori -negative ENMZL in the ileum and esophagus have also been documented.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

H pylori-Negative MALT-Associated Extranodal Marginal Zone Lymphoma: A Comprehensive Case Report and Literature Review

Qureshi,

Patel,

Ajumobi

2024

Journal of Investigative Medicine High Impact Case Reports

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Extranodal marginal zone B-cell lymphoma (ENMZL) of mucosa-associated lymphoid tissue (MALT), a rare subtype of B-cell lymphoma, is typically associated with Helicobacter pylori ( H pylori) infection, especially in gastric cases. However, this article presents 2 unique cases of H pylori-negative colonic ENMZL, challenging the conventional understanding of the disease. The first case involves an 80-year-old male diagnosed with Stage 1E ENMZL in the descending colon, and the second describes a 74-year-old male with sigmoid colon ENMZL. Both cases lacked H pylori infection, adding complexity to their management. Accompanying these case studies is a comprehensive literature review, delving into the epidemiology, pathology, clinical features, diagnosis, and treatment of H pylori-negative ENMZL, with a focus on gastrointestinal involvement. This review highlights the importance of considering H pylori-negative cases in ENMZL diagnosis and management, illustrating the need for further research and individualized treatment approaches in this uncommon lymphoma subtype.

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“…J Can Sci Res 3: 02. doi:10.4172/2576-1447.1000S2-002 [11], some cases have reported the possibility that antibiotic therapy for H. pylori is as effective for rectum MALT lymphoma as it is for gastric MALT lymphoma. Interestingly, some of these cases have reported that rectum MALT lymphoma has responded to antibiotic therapy regardless of whether patients are infected with H. pylori or not [12][13][14][15][16]. This fact indicates an unspecified pathogen other than H. pylori but its detail is not well proved.…”

Section: Discussionmentioning

confidence: 99%

A Case of Rectal Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Treated Twice with Antibiotic Therapy for Helicobacter pylori.

Sakuraba¹,

Orita²,

Ito³

et al. 2018

J Can Sci Res

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Background: The effectiveness of treatment with antibiotic for mucosa-associated lymphoid tissue (MALT) lymphoma in the stomach has been widely recognized in the last few decades. On the other hand, MALT lymphoma of the rectum is rare, and some literature has reported the usefulness of eradication of Helicobacter pylori, but the standard method of treatment has not been established. Case presentation: A 72 year old woman was referred to our department with submucosal tumor of the rectum. Colonoscopy revealed three flat elevation lesions on the right wall of the lower rectum and positron emission tomography-computed tomography (PET-CT) showed accumulation of fluorodeoxyglucose (FDG) in the same area. Pathological examination was compatible with MALT lymphoma. She was diagnosed with rectal MALT lymphoma. H. pylori infection was evaluated by gastrointestinal fiber and anti H. pylori IgG antibody serology, and her stomach was infected with H. pylori. Under her consent, we selected H. pylori eradication therapy as the first-line treatment. After first-line treatment, eradication of H. pylori was unsuccessful and the tumor had reduced in size but had not disappeared. We prescribed second-line treatment drugs and her tumor had disappeared completely and she had become negative for H. pylori. Now, she has no recurrence five years after the treatment. Conclusion: We treated a case of rectal MALT lymphoma with antibiotic therapy twice. Eradication of H. pylori was as useful for the rectum MALT lymphoma as it is for gastric MALT lymphoma. There are some reports that describe methods of treatment: surgical removal, medication, radiation, chemotherapy, and some cases had received more invasive therapy like surgical removal, radiation, and chemotherapy. In those cases, there were some instances in which medication was unsuccessful so the treatment was changed to more invasive therapy. There are controversial points about appropriate amount of time needed to determine additional treatment and the criteria for determination. Due to this lack of clarity, we reviewed the literature and speculate about them. We want to emphasize the point that administering antibiotic therapy twice or more might be useful to cases that did not respond to first line treatment and therefore had to receive more invasive therapy. Antibiotic treatment has fewer side effects than other types of therapy, so if it is useful, patients receive great benefits.

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Regression of rectal MALT lymphoma after antibiotic treatment in a patient negative for Helicobacter pylori

Cited by 9 publications

References 16 publications

Guidelines for the management of Helicobacter pylori infection in Japan: 2016 Revised Edition

Guidelines for the management of Helicobacter pylori infection in Japan: 2016 Revised Edition

H pylori-Negative MALT-Associated Extranodal Marginal Zone Lymphoma: A Comprehensive Case Report and Literature Review

A Case of Rectal Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Treated Twice with Antibiotic Therapy for Helicobacter pylori.

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