Regression of MALT lymphoma of the rectum after anti–H. pylori therapy in a patient negative for H. pylori

Inoue, Fumihiko; Chiba, Tsutomu

doi:10.1053/gast.1999.0029900514b

Cited by 61 publications

(36 citation statements)

References 5 publications

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“…9,10 Furthermore, some reports have described the usefulness of H. pylori eradication strategies in MALT lymphomas at gastrointestinal sites other than the stomach. [1][2][3]11,12 However, the mechanisms by which H. pylori eradication therapy exerts beneficial effects on tumor lesions distant from the stomach remain unknown.…”

Section: Discussionmentioning

confidence: 99%

Deep infiltrative low-grade MALT (mucosal-associated lymphoid tissue) colonic lymphomas that regressed as a result of antibiotic administration: endoscopic ultrasound evaluation

et al. 2005

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Since 1997 we have experienced three cases of low-grade colonic mucosal-associated lymphoid tissue (MALT) lymphomas. The depth of tumor invasion was evaluated by endoscopic ultrasonography (EUS) and the mass lesions were all diagnosed as having extended beyond the deep region of the submucosal layer. Although all of these patients tested negative for gastric Helicobacter pylori, their tumor lesions regressed after antibiotic treatment in accordance with H. pylori eradication therapy. In general, consensus has been reached regarding antibiotic therapy for gastric MALT lymphomas. However, as a prerequisite for antibiotic therapy, the therapy has been deemed effective against these gastric tumors if the extent of infiltration, as evaluated by EUS, is limited to the mucosal layer or the superficial region of the submucosal layer. Based on the therapeutic outcomes seen in the three patients studied here, it is suggested that antibiotic therapy might be useful in treating MALT lymphomas of the colon, even in patients with advanced invasive tumors, in contrast to the extent of the lesions in the stomach suitable for antibiotic treatment. The success of the antibiotic treatment also suggests that MALT lymphomas may be caused by unknown luminal microorganisms, other than H. pylori.

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Section: Discussionmentioning

confidence: 99%

Deep infiltrative low-grade MALT (mucosal-associated lymphoid tissue) colonic lymphomas that regressed as a result of antibiotic administration: endoscopic ultrasound evaluation

et al. 2005

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“…They also stated that the association of MALT lymphoma with H. pylori is not limited to the stomach, but involves other organs in which MALT is the predominant tissue for host defense. Inoue and Chiba reported a case without infection of H. pylori whose rectal MALT lymphoma regressed after administration of antibiotics (Inoue & Chiba, 1999). Nakase et al…”

Section: Discussionmentioning

confidence: 99%

“…H. pylori infection was assessed by rapid-urease test or histological examination. Because Inoue and Chiba reported a case without infection of H. pylori whose rectal MALT lymphoma regressed after administration of antibiotics (Inoue & Chiba, 1999), the patients were treated with antibiotic treatments. After informed consent had been obtained, 8 patients underwent antibiotic treatments with a combination of antibiotics (clarithromycin and amoxicillin), and follow-up endoscopic examinations including biopsies were performed.…”

Section: Rectal Malt Lymphoma Casesmentioning

confidence: 99%

Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma

Niino¹,

Ohshima²

2012

Hodgkin's Lymphoma

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“…Several recent studies have demonstrated that H. pylori eradication therapy led to the regression of MALT lymphoma in the duodenum [18][19][20] and in the colon. 21,22 However, conflicting findings have also been reported, showing that H. pylori eradication did not lead to the regression of duodenal MALT lymphoma. 23,24 In the present patient, we did not find H. pylori in the duodenal bulb, although we detected it in the gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

Regression of MALT lymphomas coexisting in the duodenal bulb and the stomach by eradication of Helicobacter pylori

Hori¹,

Nishigami

Chiba

et al. 2002

Journal of Gastroenterology

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We report the regression of coexisting mucosa-associated lymphoid tissue (MALT) lymphomas in the duodenal bulb and gastric corpus brought about by Helicobacter pylori eradication. During an endoscopic examination, multiple polyps in the duodenal bulb were observed in a 62-year-old woman. The pathology of the duodenal polyps was low-grade B-cell MALT lymphoma. Gastric MALT lymphoma was also detected in biopsies of rough mucosa from the gastric corpus. Southern blot analysis showed rearranged bands of DNA immunoglobulin heavy chain J portion (IgH-J) in both lesions, but the positions of these bands were different in the two lesions. H. pylori was recognized in the gastric mucosa by positive serum H. pylori antibody and urease tests, while bacterial bodies were not found in the duodenal bulb. With 1 year after the successful eradication of H. pylori, both the lesions, that in the duodenal bulb and that in the gastric corpus, had disappeared. Furthermore, positive rearrangement of IgH-J was not found at either of the lesion sites. In May 2000, 3 years after the treatment, endoscopic surveillance failed to find any recurrence of these malignant lymphomas.

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Regression of MALT lymphoma of the rectum after anti–H. pylori therapy in a patient negative for H. pylori

Cited by 61 publications

References 5 publications

Deep infiltrative low-grade MALT (mucosal-associated lymphoid tissue) colonic lymphomas that regressed as a result of antibiotic administration: endoscopic ultrasound evaluation

Deep infiltrative low-grade MALT (mucosal-associated lymphoid tissue) colonic lymphomas that regressed as a result of antibiotic administration: endoscopic ultrasound evaluation

Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma

Regression of MALT lymphomas coexisting in the duodenal bulb and the stomach by eradication of Helicobacter pylori

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