Regression of Left Ventricular Hypertrophy by Converting Enzyme Inhibition in 12–15-Month-Old Spontaneously Hypertensive Rats

Fc, Amrani; Sl, Cheaw; Chevalier, Brigitte; Paolaggi, F; Jouquey, Simone; Hamon, Gilles; Swynghedauw, Bernard

doi:10.1097/00005344-199401000-00022

Cited by 17 publications

(8 citation statements)

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“…In agreement with the previous findings of Xu & Rao (1995), the LVEDP increased with the LV balloon volume and the curve was shifted to the left in the group subjected to DOCA-salt treatment (Figure 4), indicating greater increase in LV pressure with changes in volume and a decrease in myocardial compliance (Horowitz et al 1986;Amrani et al 1994;Manor et al 1995). In DOCA-salt- 118 treated groups fed with tetrandrine or the RST extract, the increases in pressure with volume changes were significantly attenuated; the effect of the RST extract was related to the dose (Figure 4).…”

Section: P-v Curve and Left Ventricle Compliancesupporting

confidence: 91%

Antihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the rat

Chen

et al. 2004

Journal of Pharmacy and Pharmacology

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In this study, we determined the effects of an extract of Radix Stephaniae Tetrandrae (RST) on arterial blood pressure and heart weight in deoxycorticosterone acetate-salt (DOCA-salt) hypertensive rats. We also determined the effects of the extract on arrhythmia and infarct induced by myocardial ischaemia and reperfusion in anaesthetized rats. We further compared the effects of the extract with those of tetrandrine, which makes up 7% of the extract and is known to act as a calcium-channel antagonist, and verapamil, a prototype calcium-channel antagonist. Treatment with RST extract returned the arterial blood pressure, cardiac compliance and coronary flow towards normal, and reduced right ventricular hypertrophy in the DOCA-salt hypertensive rat. In the anaesthetized rat, the RST extract reduced arrhythmia and infarct size induced by myocardial ischaemia and reperfusion; the effects were similar to those of tetrandrine and verapamil. The findings indicate that the RST extract acts like a calcium-channel antagonist. It may be used in the treatment of cardiovascular diseases, as are the calcium-channel antagonist and tetrandrine. More interestingly, the effects of the RST extract were of the same potency as tetrandrine. Since only 7% of the extract was tetrandrine, the observation indicates that tetrandrine was not the only component that was responsible for the actions of the extract.

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Section: P-v Curve and Left Ventricle Compliancesupporting

confidence: 91%

Antihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the rat

Chen

et al. 2004

Journal of Pharmacy and Pharmacology

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“…MCVR/g is believed to reflect the cross-sectional area of resistance vessels and to be modulated by vascular growth and any alteration in the wall/lumen ratio of resistance vessels. 23 Indeed, it has been shown that ACE inhibitors improve coronary circulation in hypertrophied myocardium 14,15 and that the improvement is mediated by a decrease in media thickness in coronary arteries 11,12 and an increase in capillary density in hypertrophied myocardium. 15,24 Precise contributions of regression in arterial wall thickness and capillary proliferation to improvement of the right MCVR/g are unclear because morphometric analysis was not undertaken in the present study.…”

Section: Coronary Hypertension and Coronary Circulationmentioning

confidence: 99%

“…7 In the rat LV pressure-overload model, LV hypertrophy is associated with impaired coronary circulation [8][9][10][11][12][13] that can be normalized by administration of an angiotensin converting enzyme (ACE) inhibitor. 11,12,14,15 In previous in vitro studies, [8][9][10][11][12][13] however, the total coronary flow rate (combined flow rate in the left and right coronary beds) was measured with a conventional Langendorff perfusion system in order to calculate the indices of coronary circulation, but such indices may reflect the mean of the left and right coronary beds, which could be very different from each other. The changes in coronary circulation that occur in the individual coronary arterial beds in LV hypertrophy have never been studied and are still unknown.…”

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confidence: 99%

Left and Right Coronary Circulation in Left Ventricular Hypertrophy. Effects of Angiotensin Converting Enzyme Inhibition.

Shimada

Avkiran

2002

Circ J

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n increasing number of clinical studies have revealed that cardiac hypertrophy is a powerful risk factor for sudden cardiac death, probably because of myocardial ischaemia. 1,2-5 Our previous study showed that left ventricular (LV) hypertrophy in the rat increases the animal's vulnerability to ventricular arrhythmias induced by LV ischaemia and reperfusion. 6 Impairment of the coronary circulation, therefore, may play a major role in the cardiac sudden death associated with LV hypertrophy. In the clinical setting, most cases of LV hypertrophy are mediated by systemic hypertension or valve disease, but it is not known if LV hypertrophy mediates coronary disorder and impairs both the left and right coronary circulation. A disorder of the right coronary circulation in the presence of LV hypertrophy should be considered, especially with regard to the treatment of ischemic heart disease. 7 In the rat LV pressure-overload model, LV hypertrophy is associated with impaired coronary circulation 8-13 that can be normalized by administration of an angiotensin converting enzyme (ACE) inhibitor. 11,12,14,15 In previous in vitro studies, [8][9][10][11][12][13] however, the total coronary flow rate (combined flow rate in the left and right coronary beds) was measured with a conventional Langendorff perfusion system in order to calculate the indices of coronary circulation, but such indices may reflect the mean of the left and right coronary beds, which could be very different from each other. The changes in coronary circulation that occur in the individual coronary arterial beds in LV hypertrophy have never been studied and are still unknown.The objectives of this study were to determine, in a rat model of pressure-overload LV hypertrophy, 16 (i) the changes that occur in coronary reserve in the left and right coronary arterial beds, with and without ACE inhibition, and (ii) the concomitant changes that occur in arterial pressure and LV mass. To achieve those objectives, we exploited the advantages of a dual coronary perfusion model 17 that enables independent perfusion of left and right coronary beds, which supply predominantly the hypertrophied LV and non-hypertrophied right ventricle, respectively. MethodsThis investigation was performed in accordance with the Home Office Guidance on the Operation of the Animals (Scientific Procedures) Act 1986, published by Her Majesty's Stationery Office, London. Induction of Aortic ConstrictionDetails of the surgical procedure have been described previously. 17 In brief, male Wistar rats (body weight, 170± 9 g) were anesthetized with Hypnorm (0.3 ml/kg body weight im) and diazepam (2.5 mg/kg body weight ip). Via a small abdominal incision, the aorta was isolated and cleared of surrounding tissue. A small titanium clip (Atrauclip, Rusch UK Ltd, High Wycombe, UK) was placed around the suprarenal aorta with specially adapted pliers set to a width of 0.45 mm. The incision was closed with vicryl and silk sutures and the rats were left to recover under a heating lamp. The rats were closely obs...

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“…Thus, inhibitors of the ACE seem to be a logical antihypertensive treatment to reduce postmenopausal hypertension. Different inhibitors of the ACE are efficient at reducing cardiac hypertrophy and hypertension in SHRs (Amrani et al . 1994; Zorzi et al .…”

Section: Discussionmentioning

confidence: 99%

The effect of enalapril on the cardiac remodelling in ovariectomized spontaneously hypertensive rats

Santos

Pereira

Mandarim-de-Lacerda

2004

Int J Experimental Path

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Angiotensin-converting enzyme inhibitors reduce the blood pressure (BP) and inhibit the generation of the angiotensin II from the inactive angiotensin I. Ten 28-week-old spontaneously hypertensive rats (SHRs) had their ovaries bilaterally removed and five rats were left intact and studied for 7 additional weeks: intact group, ovariectomized group (ovx SHRs) and ovariectomized + enalapril group (ovx + en). BP was higher in ovx SHRs and lower in treated ovx SHRs. Left ventricular (LV) mass index was greater in untreated ovx SHRs and smaller in ovx + en group. The LV cardiomyocyte (cmy) mean cross-sectional area, measured by stereology, was greater in ovx SHRs and smaller in both intact and ovx + en SHRs. Ovx significantly decreased the density of intramyocardial blood vessels (ive), but administration of enalapril was able to restore the density of the ive to that seen in intact group. The worst ive:cmy ratio was found in untreated ovx SHRs, the intact group showed a 90% greater ratio, and the treated ovx group showed a 150% greater ratio than the untreated ovx group. In conclusion, ovariectomy, in SHRs, causes cardiac hypertrophy and an unfavourable myocardial remodelling. Of the spectrum of changes seen, the major effect of enalapril appears to be mediated via an increase in the density of ive.

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Regression of Left Ventricular Hypertrophy by Converting Enzyme Inhibition in 12–15-Month-Old Spontaneously Hypertensive Rats

Cited by 17 publications

References 0 publications

Antihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the rat

Antihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the rat

Left and Right Coronary Circulation in Left Ventricular Hypertrophy. Effects of Angiotensin Converting Enzyme Inhibition.

The effect of enalapril on the cardiac remodelling in ovariectomized spontaneously hypertensive rats

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