Regression of Intraocular Rosai- Dorfman Disease Following Treatment with Photodynamic Therapy

Abstract

Rosai-Dorfman disease (RDD), a rare form of histiocytosis, has been reported to cause choroidal masses and subsequent serous retinal detachments. We present a case of RDD associated with a choroidal mass and retinal detachment that did not respond to corticosteroid treatment and regressed after treatment with photodynamic therapy (PDT). Following treatment, the patient had a successful anatomic and clinical outcome, with no recurrence of serous detachment and 20/25 visual acuity. This is the first report of choroidal RDD successfully treated with PDT. [ Ophthalmic Surg Lasers Imaging Retina . 2021;52:568–571.]

Photodynamic Therapy for the Treatment of Choroidal Metastases

“…Photodynamic therapy has been used to treat several chorioretinal diseases such as central serous retinopathy, age-related macular degeneration, retinal hemangioblastoma, choroidal hemangioma, histiocytosis, melanoma, and metastases with few side effects. 11–13…”

“…Photodynamic therapy has been used to treat several chorioretinal diseases such as central serous retinopathy, age-related macular degeneration, retinal hemangioblastoma, choroidal hemangioma, histiocytosis, melanoma, and metastases with few side effects. [11][12][13] Given PDT's advantage over other modalities in time requirement and safety, we aimed to investigate its efficacy in treating choroidal metastasis. Currently, the only reports of PDT for choroidal metastases include single-center retrospective studies.…”