Regression of high-grade gastric mucosa-associated lymphoid tissue lymphoma with Helicobacter pylori after triple antibiotic therapy

Ng, Wai-Wah; Lam, C P; Chau, Wing‐Keung; Li, Anna Fen–Yau; Huang, Chung‐Ming; Chang, Full Young; Lee, Shou Dong

doi:10.1016/s0016-5107(00)70399-3

Cited by 32 publications

(16 citation statements)

References 15 publications

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“…Roggero and colleagues14 reported four cases with localised disease (stage I) who had a complete response after eradication therapy that was maintained after a median follow up of 16 months. Ng and colleagues15 reported a complete response lasting 18 months in a high grade gastric MALT lymphoma presenting as a solitary large gastric ulcer in the antrum. Morgner and colleagues16 described the histological regression of gastric high grade MALT lymphoma in six of seven patients initially treated only with H pylori eradication, and that in four of them the remission persisted for 6–66 months without further treatment.…”

Section: Discussionmentioning

confidence: 99%

Regression of gastric high grade mucosa associated lymphoid tissue (MALT) lymphoma after Helicobacter pylori eradication

Montalbán

Santón²,

Boixeda³

et al. 2001

Gut

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Background-Most low grade gastric lymphomas arising from the mucosa associated lymphoid tissue (MALT) are related to Helicobacter pylori colonisation. Cases with disease limited to the stomach can be cured after H pylori eradication and remain in remission for years. In contrast, high grade lymphomas of the stomach, although also related to H pylori, do not usually respond to eradication treatment. Case report-A 36 year old patient was referred from another hospital with a diagnosis of a low grade gastric MALT lymphoma associated with H pylori. The patient was in stage I and while waiting for the biopsies to be reviewed H pylori eradication therapy was given as the first step of treatment. Review of the biopsies showed a high grade immunoblastic lymphoma with areas of low grade gastric MALT lymphoma (high grade gastric MALT lymphoma or diVuse large B cell lymphoma with areas of MALT type lymphoma of the WHO classification). The patient received no further treatment but has been closely followed up for 32 months with sequential endoscopies to obtain biopsies for histological studies, H pylori cultures, and polymerase chain reaction analysis of the IgH gene. Results-After H pylori eradication the patient had a complete histological response that has been maintained for 32 months. Monoclonal IgH gene rearrangement persisted for 32 months. Conclusion-The response of this patient indicates the possibility that some cases of high grade gastric MALT lymphoma (possibly patients in stage I with a superficial or limited disease) may still be responsive to H pylori antigenic drive and may be cured with eradication therapy. Prospective studies should be performed to identify patients with high grade gastric MALT lymphomas that may respond to eradication therapy and be spared of other more aggressive treatments. (Gut 2001;49:584-587)

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Section: Discussionmentioning

confidence: 99%

Regression of gastric high grade mucosa associated lymphoid tissue (MALT) lymphoma after Helicobacter pylori eradication

Montalbán

Santón²,

Boixeda³

et al. 2001

Gut

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“…8,[10][11][12][13][14][15][16] It is reported, furthermore, that the probability of complete remission of gastric DLBL after H. pylori eradication is correlated with the depth of tumor invasion, especially when the tumor is limited to the mucosa and submucosa. 15,48 In our patients, anti-H. pylori therapy was provided to prevent possible recurrence after informed consent was obtained.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous remission of primary diffuse large B-cell gastric lymphoma

et al. 2005

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Spontaneous and complete disappearance of diffuse large B-cell lymphoma (DLBL) of the stomach is extremely rare. Although regression of gastric DLBL after eradication of Helicobacter pylori has recently been reported, we present two consecutive cases of stage I DLBL of the stomach which disappeared after only nonspecific therapy, including histamine 2-receptor antagonist (H2RA); both cases were documented histologically and endoscopically. Both patients were positive for H. pylori, and later received H. pylori eradication therapy. The disease has not recurred after 11 and 6 months, respectively. Our cases suggest that the option of combination therapy with H2RA either with or followed by H. pylori eradication is appropriate for consideration as an initial approach in standard therapy for stage I diffuse large B-cell gastric lymphoma.

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“…Certaines é tudes ont suggé ré qu'un taux é levé de grandes cellules (5 à 10 % avec des amas de moins de 20 cellules) dé veloppé es dans le LGM de bas grade é tait de mauvais pronostic et diminuait grandement les chances de ré mission aprè s traitement é radicateur [9], ce qui n'est pas confirmé dans notre expé rience [15]. Ces constatations sont conforté es par des é tudes rapportant des cas de lymphome de haut grade mis en ré mission sous traitement é radicateur de l'infection à H. pylori seule [22]. fré quente en cas de stade IIE (62 %) qu'en cas de stade IE (20 %), mais son incidence n'est pas plus é levé e en cas de stade IV [14].…”

Section: Grade Histologique Et Traitement é Radicateurunclassified

Diagnosis and therapeutic management of gastric MALT lymphoma

Delchier¹,

Lévy²

2008

Oncologie

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Gastric MALT (mucosa associated lymphoid tissue) lymphoma is a B lymphoma characterised by a tumoural infiltration of the gastric mucosa with specific small lymphocytes from MALT. Histological diagnosis may be difficult and needs to be established by adequately trained pathologists. It may regress after Helicobacter pylori eradication. The treatment of non responding patients remains debated: radiotherapy, chemotherapy, immunotherapy AE chemotherapy are currently under evaluation. The related risk of metachronous gastric cancer necessitates longterm endoscopic follow-up.

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Regression of high-grade gastric mucosa-associated lymphoid tissue lymphoma with Helicobacter pylori after triple antibiotic therapy

Cited by 32 publications

References 15 publications

Regression of gastric high grade mucosa associated lymphoid tissue (MALT) lymphoma after Helicobacter pylori eradication

Regression of gastric high grade mucosa associated lymphoid tissue (MALT) lymphoma after Helicobacter pylori eradication

Spontaneous remission of primary diffuse large B-cell gastric lymphoma

Diagnosis and therapeutic management of gastric MALT lymphoma

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