Regression of Ductal Carcinoma In Situ After Treatment with Acupuncture

Dehen, Regina

doi:10.1089/acm.2012.0696

Cited by 5 publications

(5 citation statements)

References 32 publications

(18 reference statements)

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“…In this regard, acupuncture has been used to treat the side effects of cancer therapy as well as the fatigue, pain, sleep disturbances, and lymphedema associated with many types of tumors [1–3, 32, 33]. While there are a number of studies that have provided evidence for the antinociceptive, antifatigue, and antiemetic effects of EA in cancer patients [4, 33], there is only one case report that suggests that acupuncture may actually affect the tumor itself (by causing regression of human ductal carcinoma [34]). Moreover, there are no controlled studies in the literature that we are aware of that have evaluated acupuncture's effect on tumor metastasis and no studies that have examined potential sex differences in EA's effect on tumor growth.…”

Section: Discussionmentioning

confidence: 99%

“…While there are a number of studies that have examined the use of Chinese herbs and botanicals to treat cancer [35, 36], there are very few studies in the literature that have examined the effects of acupuncture on tumor growth or metastasis. Recently, Dehen [34] described a human case of ductal carcinoma in situ that regressed after treatment with acupuncture and Chinese herbs without surgery or chemotherapy. While this is only an “ n ” of one, it represents one of the first reports showing an effect of acupuncture and Chinese herbs on tumor growth.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis: Analysis of Different Treatment Regimens

Smeester

Al-Gizawiy

O'Brien

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Osteosarcoma is the most common malignant bone tumor found in children and adolescents and is associated with many complications including cancer pain and metastasis. While cancer patients often seek complementary and alternative medicine (CAM) approaches to treat cancer pain and fatigue or the side effects of chemotherapy and treatment, there is little known about the effect of acupuncture treatment on tumor growth and metastasis. Here we evaluate the effects of six different electroacupuncture (EA) regimens on osteosarcoma tumor growth and metastasis in both male and female mice. The most significant positive effects were observed when EA was applied to the ST-36 acupoint twice weekly (EA-2X/3) beginning at postimplantation day 3 (PID 3). Twice weekly treatment produced robust reductions in tumor growth. Conversely, when EA was applied twice weekly (EA-2X/7), starting at PID 7, there was a significant increase in tumor growth. We further demonstrate that EA-2X/3 treatment elicits significant reductions in tumor lymphatics, vasculature, and innervation. Lastly, EA-2X/3 treatment produced a marked reduction in pulmonary metastasis, thus providing evidence for EA's potential antimetastatic capabilities. Collectively, EA-2X/3 treatment was found to reduce both bone tumor growth and lung metastasis, which may be mediated in part through reductions in tumor-associated vasculature, lymphatics, and innervation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis: Analysis of Different Treatment Regimens

Smeester

Al-Gizawiy

O'Brien

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Following onset, breast cancer in a preclinical stage can progress to the next preclinical stage (dependent on the duration of the previous state), or become clinically detected. In addition, the DCIS stages may also regress to normal [ 24 , 25 ]. Screening is superimposed on this life history.…”

Section: Methodsmentioning

confidence: 99%

The distribution of ductal carcinoma in situ (DCIS) grade in 4232 women and its impact on overdiagnosis in breast cancer screening

et al. 2016

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BackgroundThe incidence of ductal carcinoma in situ (DCIS) has rapidly increased over time. The malignant potential of DCIS is dependent on its differentiation grade.MethodsOur aim is to determine the distribution of different grades of DCIS among women screened in the mass screening programme, and women not screened in the mass screening programme, and to estimate the amount of overdiagnosis by grade of DCIS. We retrospectively included a population-based sample of 4232 women with a diagnosis of DCIS in the years 2007–2009 from the Nationwide network and registry of histopathology and cytopathology in the Netherlands. Excluded were women with concurrent invasive breast cancer, lobular carcinoma in situ and no DCIS, women recently treated for invasive breast cancer, no grade mentioned in the record, inconclusive record on invasion, and prevalent DCIS. The screening status was obtained via the screening organisations. The distribution of grades was incorporated in the well-established and validated microsimulation model MISCAN.ResultsOverall, 17.7 % of DCIS were low grade, 31.4 % intermediate grade, and 50.9 % high grade. This distribution did not differ by screening status, but did vary by age. Older women were more likely to have low-grade DCIS than younger women. Overdiagnosis as a proportion of all cancers in women of the screening age was 61 % for low-grade, 57 % for intermediate-grade, 45 % for high-grade DCIS. For women age 50–60 years with a high-grade DCIS this overdiagnosis rate was 21–29 %, compared to 50–66 % in women age 60–75 years with high-grade DCIS.ConclusionsAmongst the rapidly increasing numbers of DCIS diagnosed each year is a significant number of overdiagnosed cases. Tailoring treatment to the probability of progression is the next step to preventing overtreatment. The basis of this tailoring could be DCIS grade and age.

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“…She received acupuncture treatment by stimulation at the Tai Chong (19 times), followed by Zu San Li, He Gu, Qi Hai, Fenglong, and San Yin Jiao along with the use of four TCM extracts and a prescribed diet. This noninvasive form of breast carcinoma regressed by 75% over a treatment period of 15 months [49]. Zu San Li, Neiguan, Ge Shu, Fei Shu, Guan Yuan, and Shen Shu were the acupoints represented in their order of frequency of use in the treatment of lung cancer.…”

Section: Cancermentioning

confidence: 99%

Clinical Events Associated with Acupuncture Intervention for the Treatment of Chronic Inflammation Associated Disorders

Bai

et al. 2020

Mediators of Inflammation

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Acupuncture is a key component of Chinese medicine. It describes a series of procedures involving the stimulation of skin through penetration of fine, single-use, sterile needles that result in the release of neurotransmitters. Although its use is on the growing trend, considerable controversy surrounds its value as a therapy. Standard randomized controlled trials that adhere to the accepted criteria should be conducted in the future to ensure the effectiveness of acupuncture. This article summarizes the current evidence regarding the use of acupuncture. It includes a description of the history, mode of operation, treatment of a variety of chronic disorders related to inflammation, and future directions for acupuncture use. Published clinical trials support the view that acupuncture is a possible candidate for the treatment of several chronic inflammation-related disorders.

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Regression of Ductal Carcinoma In Situ After Treatment with Acupuncture

Cited by 5 publications

References 32 publications

The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis: Analysis of Different Treatment Regimens

The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis: Analysis of Different Treatment Regimens

The distribution of ductal carcinoma in situ (DCIS) grade in 4232 women and its impact on overdiagnosis in breast cancer screening

Clinical Events Associated with Acupuncture Intervention for the Treatment of Chronic Inflammation Associated Disorders

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