Regression of corneal opacity and neovascularization in Stevens-Johnson syndrome and Toxic Epidermal Necrolysis with the use of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment

Liao, Jennifer; Asghari, Bita; Carrasquillo, Karen G.

doi:10.1016/j.ajoc.2022.101520

Cited by 4 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…15 Channel technology used in the design of a PROSE scleral lens are placed on the posterior haptic of a scleral lens to prevent suction. 16,17 Customized optics correcting for HOAs also optimized BCVA. This level of customization proved necessary to achieve design optimization.…”

Section: Discussionmentioning

confidence: 99%

Early Postoperative Therapeutic Scleral Lens Intervention for Penetrating Keratoplasty Complications in Atopic Keratoconjunctivitis

Asghari¹,

Brocks²

2023

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

Self Cite

View full text Add to dashboard Cite

A 52-year-old white man with keratoconus and severe atopic keratoconjunctivitis underwent penetrating keratoplasty (PK) for visual rehabilitation in the left eye. Post-PK complications included a persistent epithelial defect. Therapeutic scleral lens wear was initiated 2 weeks post-PK. Customizations were incorporated into the lens design to prevent suction and corneal hypoxia during lens wear. Post-PK herpes epithelial keratitis developed shortly thereafter, causing recurrence of a nonhealing epithelial defect. The patient was treated with oral antiviral therapy, discontinuation of dupilumab, and daily waking-hour scleral lens wear, which was used as an antibiotic drug delivery device. The cornea fully epithelialized, and best-corrected visual acuity improved to 20/40-2. The patient continued with daily waking-hour scleral lens wear and was without recurrence of persistent epithelial defect or herpes keratitis at 18 months. No scleral lens–related complications were observed despite the unconventional early intervention with a therapeutic scleral lens.

show abstract

Section: Discussionmentioning

confidence: 99%